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MATSUOKA Isao

Profile Research field Research achievement Educational achievement Management achievement Social contribution achievement

 

Published Papers
No.Title URL, Journal, Vol( No), Start Page- End Page, Publication date, DOI 
1
Modulation of prostaglandin transport activity of SLCO2A1 by annexin A2 and S100A10 , American Journal of Physiology-Cell Physiology, ,   , Feb. 19, 2024, https://doi.org/10.1152/ajpcell.00701.2023 
2
P2X4受容体を介したATPによるマスト細胞の活性化の増強 , Folia Pharmacologica Japonica, 159( 1), 39- 43, Jan. 1, 2024, https://doi.org/10.1254/fpj.23083 
3
Amplification of poly(I:C)-induced interleukin-6 production in human bronchial epithelial cells by priming with interferon-γ , Scientific Reports, 13( 1),  , Nov. 29, 2023, https://doi.org/10.1038/s41598-023-48422-9 
4
Exploratory study of oxatomide derivatives with high P2X7 receptor inhibitory activity , Bioorganic & Medicinal Chemistry Letters, 77,  129035- 129035, Dec. 2022, https://doi.org/10.1016/j.bmcl.2022.129035 
5
P2X4 receptor stimulation enhances MrgprB2-mediated mast cell activation and pseudoallergic reactions in mice , Scientific Reports, 12( 1),  , Nov. 3, 2022, https://doi.org/10.1038/s41598-022-21667-6 
6
Purinergic regulation of mast cell function: P2X4 receptor-mediated enhancement of allergic responses. , Journal of pharmacological sciences, 150( 2), 94- 99, Oct. 2022, https://doi.org/10.1016/j.jphs.2022.07.005 
7
Synergistic Cytokine Production by ATP and PGE2 via P2X4 and EP3 Receptors in Mouse Bone-Marrow-Derived Mast Cells , Cells, 11( 4), 616- 616, Feb. 10, 2022, https://doi.org/10.3390/cells11040616 
8
P2X4 receptor signaling potentiate Mas-relate G protein-coupled receptor B2 induced mast cell activation. , Proceedings for Annual Meeting of The Japanese Pharmacological Society, 95,  1-YIA-37- , 2022, https://doi.org/10.1254/jpssuppl.95.0_1-yia-37 
9
Effects of stretch-induced mechanical stimulation on macrophage function. , Proceedings for Annual Meeting of The Japanese Pharmacological Society, 95,  2-P-162- , 2022, https://doi.org/10.1254/jpssuppl.95.0_2-p-162 
10
Differential Effects of Gq Protein-Coupled Uridine Receptor Stimulation on IL-8 Production in 1321N1 Human Astrocytoma Cells. , Biological & pharmaceutical bulletin, 45( 6), 691- 697, 2022, https://doi.org/10.1248/bpb.b21-01020 
11
Regulation by purinergic signal of glucose-induced insulin secretion from iGL insulinoma cells. , Proceedings for Annual Meeting of The Japanese Pharmacological Society, 94,  3-P2-20- , 2021, https://doi.org/10.1254/jpssuppl.94.0_3-p2-20 
12
Upregulation of P2X7 receptor  signaling by interleukin-33 in mouse bone marrow-derived mast cells , Proceedings for Annual Meeting of The Japanese Pharmacological Society, 94,  1-P2-27- , 2021, https://doi.org/10.1254/jpssuppl.94.0_1-p2-27 
13
Extracellular ATP Augments Antigen-Induced Murine Mast Cell Degranulation and Allergic Responses via P2X4 Receptor Activation. , Journal of immunology, 204( 12), 3077- 3085, Jun. 15, 2020, https://doi.org/10.4049/jimmunol.1900954 
14
Co-Stimulation of Purinergic P2X4 and Prostanoid EP3 Receptors Triggers Synergistic Degranulation in Murine Mast Cells. , International journal of molecular sciences, 20( 20), 5157- , Oct. 2019, https://doi.org/10.3390/ijms20205157 
15
Lysophosphatidylinositol-acyltransferase-1 is involved in cytosolic Ca2+ oscillations in macrophages , GENES TO CELLS, 24( 5), 366- 376, May. 2019, https://doi.org/10.1111/gtc.12681 
16
Functional coupling between adenosine A1 receptors and G-proteins in rat and postmortem human brain membranes determined with conventional guanosine-5′-O-(3-[35S]thio)triphosphate ([35S]GTPγS) binding or [35S]GTPγS/immunoprecipitation assay , Purinergic Signalling, 14( 2), 177- 190, Jun. 1, 2018, https://doi.org/10.1007/s11302-018-9603-x 
17
Effects of dexamethasone on purinergic signaling in murine mast cells: Selective suppression of P2X7 receptor expression , BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 493( 4), 1587- 1593, Dec. 2017, https://doi.org/10.1016/j.bbrc.2017.10.020 
18
Identification of novel selective P2Y(6) receptor antagonists by high-throughput screening assay , LIFE SCIENCES, 180,  137- 142, Jul. 2017, https://doi.org/10.1016/j.lfs.2017.05.017 
19
Divergent regulatory roles of extracellular ATP in the degranulation response of mouse bone marrow-derived mast cells , INTERNATIONAL IMMUNOPHARMACOLOGY, 43,  99- 107, Feb. 2017, https://doi.org/10.1016/j.intimp.2016.12.014 
20
Differential effects of lysophosphatidylcholine and ACh on muscarinic K+,non-selective cation and Ca2+ currents in guinea-pig atrial cells , Fukushima J Med Sci., 62( 1), 27- 35, 2016, https://doi.org/10.5387/fms.2015-23 
21
P2X7 receptor antagonist activity of the anti-allergic agent oxatomide , EUROPEAN JOURNAL OF PHARMACOLOGY, 767,  41- 51, Nov. 2015, https://doi.org/10.1016/j.ejphar.2015.10.002 
22
Inhibition of P2Y(6) receptor-mediated phospholipase C activation and Ca2+ signalling by prostaglandin E-2 in J774 murine macrophages , EUROPEAN JOURNAL OF PHARMACOLOGY, 749,  124- 132, Feb. 2015, https://doi.org/10.1016/j.ejphar.2014.12.024 
23
Loss of ectonucleotidases from the coronary vascular bed after ischemia-reperfusion in isolated rat heart , BMC Cardiovascular Disorders, 13,  53- , Jul. 28, 2013, https://doi.org/10.1186/1471-2261-13-53 
24
Inactivation of Membrane Surface Ecto-5 '-nucleotidase by Sodium Nitroprusside in C6 Glioma Cells , JOURNAL OF PHARMACOLOGICAL SCIENCES, 117( 1), 45- 53, Sep. 2011, https://doi.org/10.1254/jphs.11017FP 
25
Transcripts expressed using a bicistronic vector pIREShyg2 are sensitized to nonsense-mediated mRNA decay , BMC MOLECULAR BIOLOGY, 11,  42- , Jun. 2010, https://doi.org/10.1186/1471-2199-11-42 
26
Mechanism and Role of High Density Lipoprotein-induced Activation of AMP-activated Protein Kinase in Endothelial Cells , JOURNAL OF BIOLOGICAL CHEMISTRY, 285( 7), 4387- 4397, Feb. 2010, https://doi.org/10.1074/jbc.M109.043869 
27
[Negative regulatory mechanism of phospholipase C signaling triggered by G protein-coupled receptor]. , Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 134( 5), 254- 258, Nov. 2009, https://doi.org/10.1254/fpj.134.254 
28
Lysophosphatidylcholine Increases Na+/Ca2+ Exchanger Expression via RhoB-Geranylgeranylation in H9c2 Cells , JOURNAL OF PHARMACOLOGICAL SCIENCES, 109( 4), 565- 572, Apr. 2009, https://doi.org/10.1254/jphs.08253FP 
29
Na+-Ca2+ Exchanger Expression and Its Modulation , BIOLOGICAL & PHARMACEUTICAL BULLETIN, 32( 3), 325- 331, Mar. 2009, https://doi.org/10.1248/bpb.32.325 
30
Selective up-regulation of P2X(4)-receptor gene expression by interferon-gamma in vascular endothelial cells , JOURNAL OF PHARMACOLOGICAL SCIENCES, 107( 4), 419- 427, Aug. 2008, https://doi.org/10.1254/jphs.08073FP 
31
Regulation of purinergic signaling by prostaglandin E-2 in murine macrophages , JOURNAL OF PHARMACOLOGICAL SCIENCES, 107( 4), 443- 450, Aug. 2008, https://doi.org/10.1254/jphs.08087FP 
32
Acidic preconditioning inhibits Na(+)/H(+) and Na(+)/Ca(2+) exchanger interaction via PKC epsilon in guinea-pig ventricular myocytes , JOURNAL OF PHARMACOLOGICAL SCIENCES, 107( 3), 309- 316, Jul. 2008, https://doi.org/10.1254/jphs.08049FP 
33
Contractile responses of prostatic and epididymal portions of isolated rabbit vas deferens to electrical field stimulation. , Fukushima journal of medical science, 54( 1), 4- 10, Jun. 2008, https://doi.org/10.5387/fms.54.4 
34
Terminally differentiated neutrophils predominantly express survivin-2 alpha, a dominant-negative isoform of survivin , JOURNAL OF LEUKOCYTE BIOLOGY, 83( 2), 393- 400, Feb. 2008, https://doi.org/10.1189/jlb.0507282 
35
Mechanism of Na+/Ca2+ exchanger activation by hydrogen peroxide in guinea-pig ventricular myocytes , JOURNAL OF PHARMACOLOGICAL SCIENCES, 103( 3), 283- 292, Mar. 2007, https://doi.org/10.1254/jphs.FP0060015 
36
Modulation pathways of NCX mRNA stability: Involvement of RhoB , Annals of the New York Academy of Sciences, 1099,  193- 194, 2007, https://doi.org/10.1196/annals.1387.062 
37
Nitric oxide modulates biphasic contractile response of guinea pig vas deferens to electrical field stimulation. , Fukushima journal of medical science, 52( 2), 45- 57, Dec. 2006, https://doi.org/10.5387/fms.52.45 
38
Inhibitory effect of thiopental on ultra-rapid delayed rectifier K+ current in H9c2 cells , JOURNAL OF PHARMACOLOGICAL SCIENCES, 99( 2), 177- 184, Oct. 2005, https://doi.org/10.1254/jphs.FP0050583 
39
Down-regulation of Na+/Ca2+ exchanger by fluvastatin in rat cardiomyoblast H9c2 cells: Involvement of RhoB in Na+/Ca-2+ exchanger mRNA stability , MOLECULAR PHARMACOLOGY, 68( 2), 414- 420, Aug. 2005, https://doi.org/10.1124/mol.104.000786 
40
Accumulation of an intron-retained mRNA for granulocyte macrophage-colony stimulating factor receptor common beta chain in neutrophils of myelodysplastic syndromes , JOURNAL OF LEUKOCYTE BIOLOGY, 77( 5), 811- 819, May. 2005, https://doi.org/10.1189/jlb.0904488 
41
Effects of sex steroids on expression of adenylyl cyclase messenger RNA in rat uterus , JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 28( 4), 357- 362, Apr. 2005,  
42
Thrombin-induced rapid geranylgeranylation of RhoA as an essential process for RhoA activation in endothelial cells , JOURNAL OF BIOLOGICAL CHEMISTRY, 280( 11), 10182- 10188, Mar. 2005, https://doi.org/10.1074/jbc.M409447500 
43
Effects of amiodarone on mutant Na(+)/Ca(2+) exchangers expressed in CCL 39 cells , EUROPEAN JOURNAL OF PHARMACOLOGY, 496( 1-3), 49- 54, Aug. 2004, https://doi.org/10.1016/j.ejphar.2004.06.020 
44
Dual roles of 5-hydroxytryptamine in ischemia-reperfusion injury in isolated rat hearts , JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS, 9( 1), 43- 50, Mar. 2004, https://doi.org/10.1177/107424840400900i107 
45
ATP- and adenosine-mediated signaling in the central nervous system: Adenosine receptor activation by ATP through rapid and localized generation of adenosine by ecto-nucleotidases , JOURNAL OF PHARMACOLOGICAL SCIENCES, 94( 2), 95- 99, Feb. 2004, https://doi.org/10.1254/jphs.94.95 
46
A comparative study on contractile responses of rabbit and guinea pig vasa deferentia to electrical field stimulation. , Fukushima journal of medical science, 50( 2), 55- 64, Jan. 1, 2004, https://doi.org/10.5387/fms.50.55 
47
Inhibitory effect of fluvastatin on lysophosphatidylcholine-induced nonselective cation current in guinea pig ventricular myocytes , MOLECULAR PHARMACOLOGY, 62( 3), 602- 607, Sep. 2002, https://doi.org/10.1124/mol.62.3.602 
48
Chronic administration of amiodarone does not affect Na(+)/Ca(2+) exchange current in guinea pig cardiac ventricular myocytes , JAPANESE JOURNAL OF PHARMACOLOGY, 90( 1), 21- 27, Sep. 2002, https://doi.org/10.1254/jjp.90.21 
49
Adenine nucleotide-induced activation of adenosine A(2B) receptors expressed in Xenopus laevis oocytes: Involvement of a rapid and localized adenosine formation by ectonucleotidases , MOLECULAR PHARMACOLOGY, 61( 3), 606- 613, Mar. 2002, https://doi.org/10.1124/mol.61.3.606 
50
HMG-CoA reductase inhibitors suppress intracellular calcium mobilization and membrane current induced by lysophosphatidylcholine in endothelial cells , CIRCULATION, 105( 8), 962- 967, Feb. 2002, https://doi.org/10.1161/hc0802.104457 
51
Effects of anions on ATP-induced [Ca2+]i increase in NG108-15 cells , Japanese Journal of Pharmacology, 89( 3), 302- 308, 2002, https://doi.org/10.1254/jjp.89.302 
52
Characteristics of ATP-induced current through P2X7 receptor in NG108-15 cells: Unique antagonist sensitivity and lack of pore formation , Japanese Journal of Pharmacology, 88( 4), 428- 435, 2002, https://doi.org/10.1254/jjp.88.428 
53
Inhibitory effects of metals on ATP-induced current through P2X7 receptor in NG108-15 cells , Japanese Journal of Pharmacology, 89( 3), 296- 301, 2002, https://doi.org/10.1254/jjp.89.296 
54
beta,gamma-methylene ATP-induced cAMP formation in C6Bu-1 cells: involvement of local metabolism and subsequent stimulation of adenosine A(2B) receptor , JOURNAL OF NEUROCHEMISTRY, 76( 3), 872- 880, Feb. 2001, https://doi.org/10.1046/j.1471-4159.2001.00098.x 
55
Qualitatively different response of isolated rabbit aorta to methylene blue administered from intimal and adventitial surface. , Fukushima journal of medical science, 47( 2), 63- 73, Jan. 1, 2001, https://doi.org/10.5387/fms.47.63 
56
Inhibitory effect of 2,3-butanedione monoxime (BDM) on Na+/Ca2+ exchange current in guinea-pig cardiac ventricular myocytes , British Journal of Pharmacology, 132( 6), 1317- 1325, 2001, https://doi.org/10.1038/sj.bjp.0703926 
57
Effects of P-1 and P2 receptor antagonists on beta,gamma-methyleneATP- and CGS21680-induced cyclic AMP formation in NG108-15 cells , BRITISH JOURNAL OF PHARMACOLOGY, 129( 2), 291- 298, Jan. 2000, https://doi.org/10.1038/sj.bjp.0703053 
58
Effects of AMP derivatives on cyclic AMP levels in NG108-15 cells , British Journal of Pharmacology, 129( 6), 1244- 1250, 2000, https://doi.org/10.1038/sj.bjp.0703168 
59
Correlation between adenine nucleotide-induced cyclic AMP elevation and extracellular adenosine formation in NG108-15 cells , Japanese Journal of Pharmacology, 84( 3), 325- 333, 2000, https://doi.org/10.1254/jjp.84.325 
60
Ecto-alkaline phosphatase in NG108-15 cells: A key enzyme mediating P1 antagonist-sensitive ATP response , British Journal of Pharmacology, 131( 8), 1667- 1672, 2000, https://doi.org/10.1038/sj.bjp.0703750 
61
No requirement of P2X1 purinoceptors for platelet aggregation , European Journal of Pharmacology, 372( 3), 305- 309, 1999, https://doi.org/10.1016/S0014-2999(99)00201-0 
62
Effect of extracellular pH on contractile responses of the guinea-pig vas deferens , Clinical and Experimental Pharmacology and Physiology, 26( 1), 35- 38, 1999, https://doi.org/10.1046/j.1440-1681.1999.02984.x 
63
Effects of YT-146 [2-(1-octynyl) adenosine], an adenosine A(2A) receptor agonist, on cAMP production and noradrenaline release in PC12 cells , JAPANESE JOURNAL OF PHARMACOLOGY, 78( 3), 269- 277, Nov. 1998, https://doi.org/10.1254/jjp.78.269 
64
Identification of P2X7 (P2Z) receptor in N18TG-2 cells and NG108-15 cells , JOURNAL OF NEUROCHEMISTRY, 70( 3), 951- 957, Mar. 1998, https://doi.org/10.1046/j.1471-4159.1998.70030951.x 
65
Contribution of endothelium in contractile response of isolated rabbit aortic preparation to electrical field stimulation. , Fukushima journal of medical science, 44,  23- 33, Jan. 1, 1998,  
66
Effects of nicotine and tobacco smoking on cardiovascular function , Fukushima Medical Journal, 48,  1- 15, Jan. 1, 1998,  
67
Inhibition of ATP-induced cAMP formation by 5'-p- fluorosulfonylbenzoyladenosine in NG108-15 cells , Naunyn-Schmiedeberg's Archives of Pharmacology, 358( 2), 153- 159, 1998, https://doi.org/10.1007/PL00005237 
68
The Transition of Mine Water Treatment in Japan and These Coming Course. , Resources Processing, 45( 2), 69- 73, 1998, https://doi.org/10.4144/rpsj1986.45.69 
69
Influence of acidification on biphasic contractile response of guinea pig vas deferens to electrical field stimulation , RESEARCH COMMUNICATIONS IN MOLECULAR PATHOLOGY AND PHARMACOLOGY, 98( 3), 293- 302, Dec. 1997,  
70
Acute methamphetamine administration increases tyrosine hydroxylase mRNA levels in the rat locus coeruleus , MOLECULAR BRAIN RESEARCH, 52( 1), 146- 150, Dec. 1997, https://doi.org/10.1016/S0169-328X(97)00266-0 
71
Selective inhibition of collagen-induced arachidonic acid liberation by 1-(5-iodonaphthalene-1-sulphonyl)-1H-hexahydro-1,4-diazepine hydrochloride (ML-7), a myosin light chain kinase inhibitor, in washed rabbit platelets , BIOCHEMICAL PHARMACOLOGY, 54( 9), 1019- 1026, Nov. 1997, https://doi.org/10.1016/S0006-2952(97)00322-5 
72
Changes in the expression of adenylyl cyclases in the rat uterus during the course of pregnancy. , BIOLOGY OF REPRODUCTION, 57( 4), 778- 782, Oct. 1997, https://doi.org/10.1095/biolreprod57.4.778 
73
Effect of a verapamil derivative (TY-10835) on spontaneous action potentials in isolated rabbit sinoatrial node , Pharmacometrics, 54( 3), 153- 160, Sep. 1, 1997,  
74
Morphine addiction: Opioid receptors and molecular mechanism of dependence , Fukushima Medical Journal, 47,  89- 98, Jul. 23, 1997,  
75
Effects of repeated methamphetamine administration on dopamine D1 receptor, D2 receptor and adenylate cyclase type V mRNA levels in the rat striatum , NEUROSCIENCE LETTERS, 222( 3), 175- 178, Feb. 1997, https://doi.org/10.1016/S0304-3940(97)13376-6 
76
Differential expression of type I, II, and V adenylyl cyclase gene in the postnatal developing rat brain , JOURNAL OF NEUROCHEMISTRY, 68( 2), 498- 506, Feb. 1997, https://doi.org/10.1046/j.1471-4159.1997.68020498.x 
77
Differential expression of type I, II, and V adenylyl cyclase gene in the postnatal developing rat brain , JOURNAL OF NEUROCHEMISTRY, 68( 2), 498- 506, Feb. 1997, https://doi.org/10.1046/j.1471-4159.1997.68020498.x 
78
Effect of 2-hexynyladenosine on spontaneous action potentials in isolated rabbit sinoatrial node , Research Communications in Pharmacology and Toxicology, 2,  85- 103, Jan. 1, 1997,  
79
Possible existence of platelet aggregation inhibitor(s) in a gas-phase extract of cigarette smoke. , Fukushima journal of medical science, 43,  1- 11, Jan. 1, 1997,  
80
Effects of ATP on phosphoinositide hydrolysis and prostaglandin E2 generation in rabbit astrocytes , Journal of Pharmacy and Pharmacology, 49( 5), 520- 524, 1997, https://doi.org/10.1111/j.2042-7158.1997.tb06835.x 
81
Effects of anions on ATP-activated nonselective cation current in NG108- 15 cells , Journal of Neurophysiology, 77( 5), 2717- 2722, 1997, https://doi.org/10.1152/jn.1997.77.5.2717 
82
Effect of a prenylamine analog (MG8926) on spontaneous action potentials in isolated rabbit sinoatrial node. , Fukushima journal of medical science, 42( 1), 1- 10, Dec. 1, 1996,  
83
ATP-activated nonselective cation current in NG108-15 cells , JOURNAL OF NEUROCHEMISTRY, 67( 1), 398- 406, Jul. 1996, https://doi.org/10.1046/j.1471-4159.1996.67010398.x 
84
Identification and characterization of a widely expressed form of adenylyl cyclase , JOURNAL OF BIOLOGICAL CHEMISTRY, 271( 23), 13900- 13907, Jun. 1996, https://doi.org/10.1074/jbc.271.23.13900 
85
Mine Drainage Treatment , Journal of MMIJ, 112( 5), 273- 281, May. 25, 1996, https://doi.org/10.2473/shigentosozai.112.273 
86
Excitatory response of rabbit myometrium to nitric oxide in vitro , RESEARCH COMMUNICATIONS IN MOLECULAR PATHOLOGY AND PHARMACOLOGY, 92( 2), 211- 224, May. 1996,  
87
Effect of duloxetine on isolated rabbit detrusor muscle , Pharmacometrics, 51( 4), 203- 210, Apr. 1, 1996,  
88
A comparative study of arachidonic acid metabolism in rabbit cultured astrocytes and human astrocytoma cells (1321N1) , General Pharmacology, 27( 2), 313- 317, 1996, https://doi.org/10.1016/0306-3623(95)02018-7 
89
Antagonism of relaxing responses to nitrovasodilators by cyanide in rabbit isolated aortic preparation. , Fukushima journal of medical science, 41( 2), 125- 134, Dec. 1, 1995,  
90
Extracellular ATP stimulates adenylyl cyclase and phospholipase C through distinct purinoceptors in NG108-15 cells , Molecular Pharmacology, 47( 4), 855- 862, 1995,  
91
Properties of NG108-15 cells as a model system to study the signal transaction pathway of ATP receptor stimulation , Folia Pharmacologica Japonica, 106,  127- 131, 1995, https://doi.org/10.1254/fpj.106.supplement_127 
92
Dominant contribution of 5-hydroxytryptamine over thromboxane A2 in contractile response of rabbit isolated aortic preparation to thrombin activated platelets , Research Communications in Molecular Pathology and Pharmacology, 90( 2), 255- 267, 1995,  
93
Mechanism of Ca2+ influx by extracellular ATP in NG108-15 cells , Folia Pharmacologica Japonica, 106,  138- 142, 1995, https://doi.org/10.1254/fpj.106.supplement_138 
94
MOLECULAR-CLONING OF THE HUMAN TYPE-VIII ADENYLYL-CYCLASE , FEBS LETTERS, 351( 1), 109- 113, Aug. 1994, https://doi.org/10.1016/0014-5793(94)00836-1 
95
CHRONIC MORPHINE ADMINISTRATION CAUSES REGION-SPECIFIC INCREASE OF BRAIN-TYPE-VIII ADENYLYL-CYCLASE MESSENGER-RNA , EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION, 268( 2), 215- 221, Jul. 1994, https://doi.org/10.1016/0922-4106(94)90191-0 
96
Localization of adenylyl and guanylyl cyclase in rat brain by in situ hybridization: Comparison with calmodulin mRNA distribution , Journal of Neuroscience, 12,  3350- 3360, Jan. 1, 1992,  
97
Adenosine Inhibits Histamine‐Induced Phosphoinositide Hydrolysis Mediated via Pertussis Toxin‐Sensitive G Protein in Human Astrocytoma Cells , Journal of Neurochemistry, 57( 3), 963- 969, 1991, https://doi.org/10.1111/j.1471-4159.1991.tb08244.x 
98
ROLE OF CA-2+ CALMODULIN IN RECEPTOR-MEDIATED PHOSPHOINOSITIDE HYDROLYSIS IN HUMAN ASTROCYTOMA-CELLS , EUROPEAN JOURNAL OF PHARMACOLOGY, 183( 4), 1607- 1607, Jul. 1990, https://doi.org/10.1016/0014-2999(90)94775-S 
99
MASTOPARAN INHIBITS PHOSPHOINOSITIDE HYDROLYSIS VIA PERTUSSIS TOXIN-INTENSIVE G-PROTEIN IN HUMAN ASTROCYTOMA-CELLS , FEBS LETTERS, 260( 1), 91- 94, Jan. 1990, https://doi.org/10.1016/0014-5793(90)80074-S 
100
Possible mechanism of α2-adrenoceptor-mediated potentiation of thromboxane A2-induced phospholipase C activation in rabbit platelets , European Journal of Pharmacology, 183( 3), 748- 749, 1990, https://doi.org/10.1016/0014-2999(90)92549-X 
101
INHIBITORY EFFECT OF 8-BROMO CYCLIC-GMP ON AN EXTRACELLULAR CA-2+-DEPENDENT ARACHIDONIC-ACID LIBERATION IN COLLAGEN-STIMULATED RABBIT PLATELETS , BIOCHEMICAL PHARMACOLOGY, 38( 11), 1841- 1847, Jun. 1989, https://doi.org/10.1016/0006-2952(89)90420-6 
102
GTP-GAMMA-S BINDING ACTIVITIES WERE REDUCED IN HEAVY MEMBRANE-FRACTION DURING DESENSITIZATION BY CA-MOBILIZING AGONISTS IN HUMAN ASTROCYTOMA-CELLS , RESEARCH COMMUNICATIONS IN CHEMICAL PATHOLOGY AND PHARMACOLOGY, 64( 2), 179- 192, May. 1989,  
103
THROMBOXANE-A2 ACTIVATES PHOSPHOLIPASE-C IN ASTROCYTOMA-CELLS VIA PERTUSSIS TOXIN-INSENSITIVE G-PROTEIN , EUROPEAN JOURNAL OF PHARMACOLOGY, 162( 3), 407- 417, Mar. 1989, https://doi.org/10.1016/0014-2999(89)90331-2 
104
Involvement of Endogenous Noradrenaline Release in Methylene Blue-Induced Contraction of Isolated Rabbit Aorta , The Japanese Journal of Pharmacology, 44( 1), 23- 33, 1987, https://doi.org/10.1254/jjp.44.23 
105
A comparison of the effects of isosorbide dinitrate on isolated rabbit aorta and vena cava: role of guanosine 3',5'-cyclic monophosphate in vascular smooth muscle relaxation. , Fukushima journal of medical science, 32,  29- 37, Jun. 1, 1986,  
106
Is there negative chronotropism via adrenergic alpha receptor in isolated rabbit atria? , Fukushima journal of medical science, 31,  99- 108, Dec. 1, 1985,  
107
Preferential antagonism of tiaramide to prostaglandin E2-induced contraction in isolated rabbit detrusor. , Fukushima journal of medical science, 31,  63- 70, Dec. 1, 1985,  
108
ISOSORBIDE 5-MONONITRATE EFFECTS ON ISOLATED RABBIT AORTA AND VENA-CAVA - RELATIONSHIP BETWEEN CYCLIC-GMP AND RELAXATION OF VASCULAR SMOOTH-MUSCLE , EUROPEAN JOURNAL OF PHARMACOLOGY, 118( 1-2), 155- 161, Nov. 1985, https://doi.org/10.1016/0014-2999(85)90674-0 
109
AN ANALYSIS OF INHIBITORY EFFECT OF CYCLIC-GMP ON ARACHIDONIC ACID-INDUCED OR COLLAGEN-INDUCED AGGREGATION IN RABBIT PLATELETS , THROMBOSIS RESEARCH, 37( 1), 185- 193, 1985, https://doi.org/10.1016/0049-3848(85)90045-3 
110
Isosorbide-5-mononitrate Pharmacokinetics after Single and Repeated Oral Dosing in Man , Japanese Journal of Clinical Pharmacology and Therapeutics, 15( 2), 317- 328, 1984, https://doi.org/10.3999/jscpt.15.317 
111
Mepacrine-induced elevation of cyclic GMP levels and acceleration of reversal of ADP-induced aggregation in washed rabbit platelets , Journal of Cyclic Nucleotide and Protein Phosphorylation Research, 9( 4-5), 341- 353, 1983,  
112
MEPACRINE-INDUCED ELEVATION OF CYCLIC-GMP LEVELS AND ACCELERATION OF REVERSAL OF ADP-INDUCED AGGREGATION IN WASHED RABBIT PLATELETS , JOURNAL OF CYCLIC NUCLEOTIDE AND PROTEIN PHOSPHORYLATION RESEARCH, 9( 4-5), 341- 353, 1983,  

 

MISC
No.Title URL, Journal, Vol( No), Start Page- End Page, Publication date 
1
Synergistic effects of IFN-γ and poly(I:C) on cytokine production in human airway epithelial NCl-H292 cells , 日本薬学会年会要旨集(Web), 142nd,   , 2022 
2
Effects of hypotonic stress on prostaglandin E2 transport of SLCO2A1 , 日本薬学会年会要旨集(Web), 142nd,   , 2022 
3
P2X4 receptor signaling enhanced psuedallergyc response , 日本薬学会年会要旨集(Web), 142nd,   , 2022 
4
Analysis of ATP-induced enhancement of interleukin 6 production in human glioblastoma , 日本薬学会年会要旨集(Web), 142nd,   , 2022 
5
Evaluation of mesenteric artery function in LPS-induced sepsis model mice , 日本薬学会年会要旨集(Web), 142nd,   , 2022 
6
Analysis of synergistic cytokine production induced by co-stimulation of ATP and PGE2 in mast cells , 日本薬学会年会要旨集(Web), 142nd,   , 2022 
7
Exacerbation of allergic responses via P2X4 receptor activation , , 41( 2), 84- 88, Feb. 2021 
8
Effects of extracellular ATP on cytokine production in mouse bone marrow-derived mast cells , 日本薬学会年会要旨集(Web), 141st,   , 2021 
9
Effect of P2X4 receptor on degranulation of connective tissue-type mast cell , 日本薬学会年会要旨集(Web), 141st,   , 2021 
10
Effect of IL-33 on purinergic receptor expression in bone marrow-derived mast cell , 日本薬学会年会要旨集(CD-ROM), 140th,   , 2020 
11
Inhibitory effects of statins on P2Y1 receptor-mediated IL-8 release , 日本薬学会年会要旨集(CD-ROM), 140th,   , 2020 
12
Synthesis of benzopyran derivatives as P2Y6 receptor antagonists , 日本薬学会年会要旨集(CD-ROM), 140th,   , 2020 
13
Inhibitory effects of oxatomide derivatives on human P2X7 receotor , 日本薬学会年会要旨集(CD-ROM), 140th,   , 2020 
14
Effects of HMG-CoA reductase inhibitors on P2Y(1) receptor-mediated IL-8 release , JOURNAL OF PHARMACOLOGICAL SCIENCES, 124,  199P- 199P, 2014 
15
Role of P2X(7) receptor-mediated signaling in human B cell like myeloma RPMI8226 cells , JOURNAL OF PHARMACOLOGICAL SCIENCES, 124,  168P- 168P, 2014 
16
Mechanism underlying statin-induced up-regulation of CD39 in endothelial cells , JOURNAL OF PHARMACOLOGICAL SCIENCES, 118,  83P- 83P, 2012 
17
The P2Y(13) receptor mediates murine macrophage chemotaxis toward extracellular ADP , JOURNAL OF PHARMACOLOGICAL SCIENCES, 115,  124P- 124P, 2011 
18
Mode of inhibitory action of prostaglandin E-2 on UDP-induced Ca2+ signaling in J774 macrophages , JOURNAL OF PHARMACOLOGICAL SCIENCES, 115,  223P- 223P, 2011 
19
Effects of prostaglandin E-2 on UDP-induced Ca2+ signaling in human P2Y(6) receptor expressed 1321N1 cells , JOURNAL OF PHARMACOLOGICAL SCIENCES, 112,  213P- 213P, 2010 
20
Effects of HMG-CoA reductase inhibitors on vascular endothelial ecto-nucleotidase activity , JOURNAL OF PHARMACOLOGICAL SCIENCES, 112,  82P- 82P, 2010 
21
Prostaglandin E-2-induced negative regulation of G(q/11)-phospholipase C signaling in macrophages , JOURNAL OF PHARMACOLOGICAL SCIENCES, 109,  38P- 38P, 2009 
22
REGULATION OF ISOPRENYL TRANSFERASE ACTIVITY BY SIGNALS FROM HETEROTRIMERIC G PROTEIN-COUPLED RECEPTORS , JOURNAL OF PHYSIOLOGICAL SCIENCES, 59,  207- 207, 2009 
23
Inhibition by prostaglandin E-2 of store-operated Ca2+ entry in UDP-stimulated murine J774 macrophage , JOURNAL OF PHARMACOLOGICAL SCIENCES, 109,  171P- 171P, 2009 
24
Multiple PTC-bearing mRNA induces a higher activity of nonsense-mediated mRNA decay than mRNA with a single PTC , JOURNAL OF PHARMACOLOGICAL SCIENCES, 106,  153P- 153P, 2008 
25
Inhibition of P2Y(6) receptor-mediated Ca2+ signaling by prostaglandin E-2 in murine J774 macrophages , JOURNAL OF PHARMACOLOGICAL SCIENCES, 106,  246P- 246P, 2008 
26
Effects of prostaglandin E-2 on purinergic signaling in murine J774 macrophages. , JOURNAL OF PHARMACOLOGICAL SCIENCES, 103,  214P- 214P, 2007 
27
No contribution of survivin to GM-CSF/G-CSF-induced anti-apoptotic effects on terminally differentiated neutrophils , JOURNAL OF PHARMACOLOGICAL SCIENCES, 103,  269P- 269P, 2007 
28
Increase in extracellular ATP hydrolysis by prostaglandin E-2 in murine J774 macrophages , JOURNAL OF PHARMACOLOGICAL SCIENCES, 103,  95P- 95P, 2007 
29
Geranylgeranylation is necessary in Na+/Ca2+ exchanger mRNA increase by lisophosphatidylcholine in H9c2 cells. , ACTA PHARMACOLOGICA SINICA, 27,  142- 142, Jul. 2006 
30
Geranylgeranylation is necessary in Na+/Ca2+ exchanger mRNA increase by lisophosphatidylcholine in H9c2 cells. , ACTA PHARMACOLOGICA SINICA, 27,  163- 163, Jul. 2006 
31
Interferon-gamma increases extracellular ATP hydrolysis through up-regulation of ecto-nucleoside triphosphate diphosphohydrolase 1 in J774 murine macrophages , JOURNAL OF PHARMACOLOGICAL SCIENCES, 100,  105P- 105P, 2006 
32
Lineage-specific survivin induction by GM-CSF , JOURNAL OF PHARMACOLOGICAL SCIENCES, 100,  168P- 168P, 2006 
33
Geranylgeranylation of RhoB in Na+/Ca2+ exchanger mRNA increase by lisophosphatidylcholine in H9c2 cells , JOURNAL OF PHARMACOLOGICAL SCIENCES, 100,  220P- 220P, 2006 
34
Effects of a nonsense-mediated mRNA decay inhibitor on a splice variant with PTCs , JOURNAL OF PHARMACOLOGICAL SCIENCES, 100,  291P- 291P, 2006 
35
Modulation mechanism of Na+/Ca2+ exchanger mRNA stability , JOURNAL OF PHARMACOLOGICAL SCIENCES, 97,  56P- 56P, 2005 
36
Mg2+ modulates evoked inhibitory post-synaptic current in rat MNTB neurons , JOURNAL OF PHARMACOLOGICAL SCIENCES, 97,  77P- 77P, 2005 
37
Involvement of Rho-GTPase in Na+/Ca2+ exchanger mRNA stability in H9c2 cells , JOURNAL OF PHARMACOLOGICAL SCIENCES, 97,  238P- 238P, 2005 
38
Nonsense-mediated mRNA decay of the intron-retained splice variant of GM-CSF receptor beta chain , JOURNAL OF PHARMACOLOGICAL SCIENCES, 97,  222P- 222P, 2005 
39
PJ-543 Hydrogen Peroxide Activates Na+/Ca2+ Exchanger through Two Different Signaling Pathways in Guinea-Pig Ventricular Myocytes(Myocardial Ischemia-Reperfusion, Basic and Clinical 3 (M) : PJ91)(Poster Session (Japanese)) , Circulation journal : official journal of the Japanese Circulation Society, 68,  613- 613, Mar. 1, 2004 
40
Dual signaling pathways of Na+/Ca2(+) exchanger activation by hydrogen peroxide in guinea pig ventricular myocytes , BIOPHYSICAL JOURNAL, 86( 1), 227A- 227A, Jan. 2004 
41
Ecto-nucleotidases in the Nerves System , Ikagaku Shinpojumu, 33( 1), 11- 18, 2004 
42
H2O2 activates Na+/Ca2+ exchange through MAPK kinase pathways in guinea-pig ventricular cells , JOURNAL OF PHARMACOLOGICAL SCIENCES, 94,  88P- 88P, 2004 
43
Accumulation of premature mRNA of GM-CSF receptor common beta subunit in myelodysplastic syndromes , JOURNAL OF PHARMACOLOGICAL SCIENCES, 94,  148P- 148P, 2004 
44
Effects of receptor agonists on ATP release from rat brain slices , JOURNAL OF PHARMACOLOGICAL SCIENCES, 94,  229P- 229P, 2004 
45
Signal transduction of hydrogen peroxide-induced Na+/Ca2+ exchange activation in guinea-pig ventricular myocytes , JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 35( 11), A30- A30, Nov. 2003 
46
A novel mutation in granulocyte-macrophage colony-stimulating factor receptor common beta subunit accumulated in myelodysplastic syndromes abolishes its cell-surface expression and function. , BLOOD, 102( 11), 913A- 913A, Nov. 2003 
47
Activation mechanism of Na+/Ca2+ exchange by hydrogen peroxide in guinea-pig ventricular myocytes. , JOURNAL OF PHARMACOLOGICAL SCIENCES, 91,  153P- 153P, 2003 
48
Possible involvement of chloride channel activation in ATP release upon electrical stimulation from rat brain slices. , JOURNAL OF PHARMACOLOGICAL SCIENCES, 91,  218P- 218P, 2003 
49
Involvement of PKC epsilon in acidic preconditioning in guinea pig ventricular cells. , JOURNAL OF PHARMACOLOGICAL SCIENCES, 91,  132P- 132P, 2003 
50
Effects of fluvastatin on Na+/Ca2+ exchanger mRNA levels in H9c2 cells. , JOURNAL OF PHARMACOLOGICAL SCIENCES, 91,  240P- 240P, 2003 
51
Expression of ectoalkaline phosphatase in N18TG-2 cells creates a P1 and P2 antagonist-sensitive and adenosine deaminase-resistant response to ATP , DRUG DEVELOPMENT RESEARCH, 56( 4), 574- 574, Aug. 2002 
52
Effect of lysophastidycholine on G protein-gated muscarinic K+ current in guinea-pig atrial myocytes , JAPANESE JOURNAL OF PHARMACOLOGY, 88,  159P- 159P, 2002 
53
Structural abnormalities of granulocyte-macrophage colony-stimulating factor receptor common beta chain in myelodysplastic syndromes. , BLOOD, 98( 11), 353A- 353A, Nov. 2001 
54
HMG-CoA reductase inhibitors suppress intracellular calcium mobilization induced by lysophosphatidylcholine mediated via inhibition of Rho/ROCK pathway in endothelial cells , CIRCULATION, 102( 18), 320- 320, Oct. 2000 
55
Regulation of adenylyl cyclase gene expression by nicotine , The Autonomic nerve system, 37( 3), 370- 375, Jun. 2000 
56
P2Z/P2X7 receptor , , 2,  241- 246, 1999 
57
Dual effects of ATP on the extracellular signal-regulated kinase pathway in NG108-15 cells , NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 358( 1), R126- R126, 1998 
58
Identification and functional characterization of prostaglandin E-2 receptor EP3 subtype in PC12 cells. , NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 358( 1), R722- R722, 1998 
59
Effects of anions on ATP-activated nonselective cation current in NG108-15 cells , JOURNAL OF NEUROPHYSIOLOGY, 77( 5), 2717- 2722, May. 1997 
60
DOMINANT CONTRIBUTION OF 5-HYDROXYTRYPTAMTNE OVER THROMBOXANE A2 IN CONTRACTILE RESPONSE OF RABBIT ISOLATED AORTIC PREPARATION TO THROMBIN-ACTIVATED PLATELETS , RESEARCH COMMUNICATIONS IN MOLECULAR PATHOLOGY AND PHARMACOLOGY, 90( 2), 255- 267, Nov. 1995 
61
DISTRIBUTION OF SOLUBLE GUANYLYL CYCLASE IN RAT-BRAIN BY IN-SITU HYBRIDIZATION , COMPTES RENDUS DES SEANCES DE LA SOCIETE DE BIOLOGIE ET DE SES FILIALES, 187( 1), 99- 100, 1993 
62
CONTRIBUTIONS OF 5-HT AND THROMBOXANE A2 RELEASED FROM PLATELETS BY THROMBIN TO INTRALUMINAL PRESSURE OF ISOLATED AORTIC PREPARATION IN RABBITS , JAPANESE JOURNAL OF PHARMACOLOGY, 43,  P123- P123, 1987 
63
INHIBITORY EFFECT OF CYCLIC-GMP ON ARACHIDONIC ACID-INDUCED RABBIT PLATELET ACTIVATION , JAPANESE JOURNAL OF PHARMACOLOGY, 43,  P169- P169, 1987 
64
EFFECT OF NICOTINE ON PLASMA-LEVELS OF CATECHOLAMINE, THROMBOXANE-A2 AND 6-KETO PROSTAGLANDIN F1-ALPHA IN CANINE CORONARY VEIN , FOLIA PHARMACOLOGICA JAPONICA, 87( 5), P40- P40, May. 1986 
65
DIFFERENT SENSITIVITY OF RABBIT AORTA TO CATECHOLAMINES, WHICH WERE ADMINISTERED FROM THE INTIMAL AND ADVENTITIAL SIDE , FOLIA PHARMACOLOGICA JAPONICA, 87( 5), P43- P43, May. 1986 
66
METHYLENE BLUE-INDUCED CONTRACTION OF ISOLATED RABBIT AORTA - EVIDENCE FOR INVOLVEMENT OF THE RELEASE OF ENDOGENOUS CATECHOLAMINE , JAPANESE JOURNAL OF PHARMACOLOGY, 40,  P268- P268, 1986 
67
RELAXING RESPONSE OF ISOLATED RABBIT AORTA TO ADENOSINE-TRIPHOSPHATE ADMINISTERED FROM INTIMAL, BUT NOT ADVENTITIAL SURFACE , JAPANESE JOURNAL OF PHARMACOLOGY, 40,  P101- P101, 1986 
68
HISTAMINE-RECEPTORS IN ISOLATED RIGHT ATRIA AND VENTRICLES OF RABBITS , JAPANESE JOURNAL OF PHARMACOLOGY, 39,  P88- P88, 1985 
69
EFFECTS OF ISOSORBIDE-5-MONONITRATE ON RABBIT AORTA AND VENA-CAVA INVITRO - RELATIONSHIP BETWEEN RELAXATION AND CYCLIC-GMP FORMATION , FOLIA PHARMACOLOGICA JAPONICA, 85( 6), P94- P94, 1985 
70
EFFECT OF METHYLENE-BLUE TREATMENT ON RABBIT PLATELET-AGGREGATION , FOLIA PHARMACOLOGICA JAPONICA, 83( 6), P65- P66, 1984 
71
EFFECT OF METHYLENE-BLUE ON AGGREGATION AND CYCLIC-GMP LEVEL IN WASHED RABBIT PLATELETS , JAPANESE JOURNAL OF PHARMACOLOGY, 36,  P84- P84, 1984 
72
Fundamental and Experimental Studies on Fetal Biochemical Monitoring Accomplished by Ion-sensitive Field-effect Transistor pH and PCO_2 Sensors , Acta obstetrica et gynaecologica Japonica, 34( 11), 1867- 1875, 1982 

 

Research Grants & Projects
No.Offer organization, System name, Title, Fund classification, Date 
1
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Establishment of therapeutic basis for allergic diseases targeting P2X4 receptor of mast cells, ,  Apr. 2019 - Mar. 2022 
2
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Novel mechanism for regulation of inflammatory response., ,  2008 - 2009 
3
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Tissue distribution and physiorogical function of ATP receptors, ,  1998 - 1999 
4
, , Role of extracellular nucleotide metabolism in regulation of physiological response, competitive_research_funding, 
5
, , Molecular Pharmacology of ATP receptors, competitive_research_funding,