Takasaki University of Health and Welfare

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ITO Masaaki

Profile Research field Research achievement Educational achievement Management achievement Social contribution achievement

 

Published Papers
No.Title URL, Journal, Vol( No), Start Page- End Page, Publication date, DOI 
1
Purinergic regulation of mast cell function: P2X4 receptor-mediated enhancement of allergic responses. , Journal of pharmacological sciences, 150( 2), 94- 99, Oct. 2022, https://doi.org/10.1016/j.jphs.2022.07.005 
2
P-glycoprotein–mediated pharmacokinetic interactions increase pimozide hERG channel inhibition , Journal of Pharmaceutical Sciences, ,   , Sep. 2022, https://doi.org/10.1016/j.xphs.2022.09.025 
3
Synergistic Cytokine Production by ATP and PGE2 via P2X4 and EP3 Receptors in Mouse Bone-Marrow-Derived Mast Cells , Cells, 11( 4), 616- 616, Feb. 10, 2022, https://doi.org/10.3390/cells11040616 
4
Differential Effects of Gq Protein-Coupled Uridine Receptor Stimulation on IL-8 Production in 1321N1 Human Astrocytoma Cells. , Biological & pharmaceutical bulletin, 45( 6), 691- 697, 2022, https://doi.org/10.1248/bpb.b21-01020 
5
Extracellular ATP Augments Antigen-Induced Murine Mast Cell Degranulation and Allergic Responses via P2X4 Receptor Activation , The Journal of Immunology, 204( 12), 3077- 3085, Jun. 15, 2020, https://doi.org/10.4049/jimmunol.1900954 
6
Gastrointestinal absorption of pimozide is enhanced by inhibition of P-glycoprotein. , PloS one, 15( 10), e0232438- , 2020, https://doi.org/10.1371/journal.pone.0232438 
7
Co-Stimulation of Purinergic P2X4 and Prostanoid EP3 Receptors Triggers Synergistic Degranulation in Murine Mast Cells. , International journal of molecular sciences, 20( 20),  , Oct. 17, 2019, https://doi.org/10.3390/ijms20205157 
8
Lysophosphatidylinositol-acyltransferase-1 is involved in cytosolic Ca2+ oscillations in macrophages. , Genes to cells : devoted to molecular & cellular mechanisms, 24( 5), 366- 376, May. 2019, https://doi.org/10.1111/gtc.12681 
9
Effects of dexamethasone on purinergic signaling in murine mast cells: Selective suppression of P2X7 receptor expression , BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 493( 4), 1587- 1593, Dec. 2017, https://doi.org/10.1016/j.bbrc.2017.10.020 
10
Identification of novel selective P2Y(6) receptor antagonists by high-throughput screening assay , LIFE SCIENCES, 180,  137- 142, Jul. 2017, https://doi.org/10.1016/j.lfs.2017.05.017 
11
Divergent regulatory roles of extracellular ATP in the degranulation response of mouse bone marrow-derived mast cells , INTERNATIONAL IMMUNOPHARMACOLOGY, 43,  99- 107, Feb. 2017, https://doi.org/10.1016/j.intimp.2016.12.014 
12
P2X7 receptor antagonist activity of the anti-allergic agent oxatomide , EUROPEAN JOURNAL OF PHARMACOLOGY, 767,  41- 51, Nov. 2015, https://doi.org/10.1016/j.ejphar.2015.10.002 
13
Inhibition of P2Y(6) receptor-mediated phospholipase C activation and Ca2+ signalling by prostaglandin E-2 in J774 murine macrophages , EUROPEAN JOURNAL OF PHARMACOLOGY, 749,  124- 132, Feb. 2015, https://doi.org/10.1016/j.ejphar.2014.12.024 
14
Loss of ectonucleotidases from the coronary vascular bed after ischemia-reperfusion in isolated rat heart , BMC Cardiovascular Disorders, 13,  53- 53, Jul. 28, 2013, https://doi.org/10.1186/1471-2261-13-53 
15
Mechanism and Role of High Density Lipoprotein-induced Activation of AMP-activated Protein Kinase in Endothelial Cells , JOURNAL OF BIOLOGICAL CHEMISTRY, 285( 7), 4387- 4397, Feb. 2010, https://doi.org/10.1074/jbc.M109.043869 
16
[Negative regulatory mechanism of phospholipase C signaling triggered by G protein-coupled receptor]. , Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 134( 5), 254- 258, Nov. 2009, https://doi.org/10.1254/fpj.134.254 
17
Regulation of purinergic signaling by prostaglandin E-2 in murine macrophages , JOURNAL OF PHARMACOLOGICAL SCIENCES, 107( 4), 443- 450, Aug. 2008, https://doi.org/10.1254/jphs.08087FP 

 

MISC
No.Title URL, Journal, Vol( No), Start Page- End Page, Publication date 
1
P2X4 receptor signaling potentiate Mas-relate G protein-coupled receptor B2 induced mast cell activation. , Proceedings for Annual Meeting of The Japanese Pharmacological Society, 95,  1-YIA-37- , 2022 
2
Evaluation of mesenteric artery function in LPS-induced sepsis model mice , 日本薬学会年会要旨集(Web), 142nd,   , 2022 
3
Analysis of ATP-induced enhancement of interleukin 6 production in human glioblastoma , 日本薬学会年会要旨集(Web), 142nd,   , 2022 
4
Effects of stretch-induced mechanical stimulation on macrophage function. , Proceedings for Annual Meeting of The Japanese Pharmacological Society, 95,  2-P-162- , 2022 
5
P2X4 receptor signaling enhanced psuedallergyc response , 日本薬学会年会要旨集(Web), 142nd,   , 2022 
6
Effects of hypotonic stress on prostaglandin E2 transport of SLCO2A1 , 日本薬学会年会要旨集(Web), 142nd,   , 2022 
7
Synergistic effects of IFN-γ and poly(I:C) on cytokine production in human airway epithelial NCl-H292 cells , 日本薬学会年会要旨集(Web), 142nd,   , 2022 
8
Analysis of synergistic cytokine production induced by co-stimulation of ATP and PGE2 in mast cells , 日本薬学会年会要旨集(Web), 142nd,   , 2022 
9
Effects of extracellular ATP on cytokine production in mouse bone marrow-derived mast cells , 日本薬学会年会要旨集(Web), 141st,   , 2021 
10
Effect of P2X4 receptor on degranulation of connective tissue-type mast cell , 日本薬学会年会要旨集(Web), 141st,   , 2021 
11
Upregulation of P2X7 receptor  signaling by interleukin-33 in mouse bone marrow-derived mast cells , Proceedings for Annual Meeting of The Japanese Pharmacological Society, 94,  1-P2-27- , 2021 
12
Regulation by purinergic signal of glucose-induced insulin secretion from iGL insulinoma cells. , Proceedings for Annual Meeting of The Japanese Pharmacological Society, 94,  3-P2-20- , 2021 
13
Inhibitory effects of statins on P2Y1 receptor-mediated IL-8 release , 日本薬学会年会要旨集(CD-ROM), 140th,   , 2020 
14
Synthesis of benzopyran derivatives as P2Y6 receptor antagonists , 日本薬学会年会要旨集(CD-ROM), 140th,   , 2020 
15
Effect of IL-33 on purinergic receptor expression in bone marrow-derived mast cell , 日本薬学会年会要旨集(CD-ROM), 140th,   , 2020 
16
Inhibitory effects of oxatomide derivatives on human P2X7 receotor , 日本薬学会年会要旨集(CD-ROM), 140th,   , 2020 
17
Role of P2X(7) receptor-mediated signaling in human B cell like myeloma RPMI8226 cells , JOURNAL OF PHARMACOLOGICAL SCIENCES, 124,  168P- 168P, 2014 
18
Effects of HMG-CoA reductase inhibitors on P2Y(1) receptor-mediated IL-8 release , JOURNAL OF PHARMACOLOGICAL SCIENCES, 124,  199P- 199P, 2014 
19
Mechanism underlying statin-induced up-regulation of CD39 in endothelial cells , JOURNAL OF PHARMACOLOGICAL SCIENCES, 118,  83P- 83P, 2012 
20
The P2Y(13) receptor mediates murine macrophage chemotaxis toward extracellular ADP , JOURNAL OF PHARMACOLOGICAL SCIENCES, 115,  124P- 124P, 2011 
21
Effects of HMG-CoA reductase inhibitors on vascular endothelial ecto-nucleotidase activity , JOURNAL OF PHARMACOLOGICAL SCIENCES, 112,  82P- 82P, 2010 
22
Effects of prostaglandin E-2 on UDP-induced Ca2+ signaling in human P2Y(6) receptor expressed 1321N1 cells , JOURNAL OF PHARMACOLOGICAL SCIENCES, 112,  213P- 213P, 2010 
23
Prostaglandin E-2-induced negative regulation of G(q/11)-phospholipase C signaling in macrophages , JOURNAL OF PHARMACOLOGICAL SCIENCES, 109,  38P- 38P, 2009 
24
REGULATION OF ISOPRENYL TRANSFERASE ACTIVITY BY SIGNALS FROM HETEROTRIMERIC G PROTEIN-COUPLED RECEPTORS , JOURNAL OF PHYSIOLOGICAL SCIENCES, 59,  207- 207, 2009 
25
Inhibition by prostaglandin E-2 of store-operated Ca2+ entry in UDP-stimulated murine J774 macrophage , JOURNAL OF PHARMACOLOGICAL SCIENCES, 109,  171P- 171P, 2009 
26
Inhibition of P2Y(6) receptor-mediated Ca2+ signaling by prostaglandin E-2 in murine J774 macrophages , JOURNAL OF PHARMACOLOGICAL SCIENCES, 106,  246P- 246P, 2008 
27
Effects of prostaglandin E-2 on purinergic signaling in murine J774 macrophages. , JOURNAL OF PHARMACOLOGICAL SCIENCES, 103,  214P- 214P, 2007 
28
Increase in extracellular ATP hydrolysis by prostaglandin E-2 in murine J774 macrophages , JOURNAL OF PHARMACOLOGICAL SCIENCES, 103,  95P- 95P, 2007 

 

Research Grants & Projects
No.Offer organization, System name, Title, Fund classification, Date 
1
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Establishment of therapeutic basis for allergic diseases targeting P2X4 receptor of mast cells, ,  Apr. 2019 - Mar. 2022 
2
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Relationship between enhanced purinergic signalling in skeletal muscle and health promoting effects of exercise training, ,  Apr. 2015 - Mar. 2017 
3
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Novel mechanism for regulation of inflammatory response., ,  2008 - 2009