Takasaki University of Health and Welfare

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OGIHARA Takuo

Profile Research field Research achievement Educational achievement Management achievement Social contribution achievement

 

Published Papers
No.Title URL, Journal, Vol( No), Start Page- End Page, Publication date, DOI 
1
Structure-activity relationship of atorvastatin derivatives for metabolic activation by hydrolases , Xenobiotica, 50( 3), 261- 269, Mar. 3, 2020, https://doi.org/10.1080/00498254.2019.1625083 
2
Reduction Effect of Calcium Alginate on Blood Triglyceride Levels Causing the Inhibition of Hepatic and Total Body Accumulation of Fat in Rats. , Biological & pharmaceutical bulletin, 42( 3), 365- 372, Mar. 2019, https://doi.org/10.1248/bpb.b18-00530 
3
Specified Kiwifruit Extract Blocks Increase of Body Weight and Visceral Fat in High-fat-diet-fed Mice Inhibiting Intestial Lipase. , Food Science and Technology Research, 25( 2), 295- 302, 2019,  
4
[Further investigation of 3D culture spheroid models of human hepatocytes]. , Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 153( 5), 235- 241, 2019, https://doi.org/10.1254/fpj.153.235 
5
Mechanism of Suppression of Blood Glucose Level by Calcium Alginate in Rats. , Biological & pharmaceutical bulletin, 41( 9), 1362- 1366, Sep. 2018, https://doi.org/10.1248/bpb.b18-00155 
6
Randomized, Double-Blind, Crossover Clinical Trial of the Effect of Calcium Alginate in Noodles on Postprandial Blood Glucose Level. , Biological & pharmaceutical bulletin, 41( 9), 1367- 1371, Sep. 2018, https://doi.org/10.1248/bpb.b18-00156 
7
Entinostat reverses P-glycoprotein activation in snail-overexpressing adenocarcinoma HCC827 cells. , PloS one, 13( 7), e0200015- , Jul. 6, 2018, https://doi.org/10.1371/journal.pone.0200015 
8
Intestinal secretion of indoxyl sulfate as a possible compensatory excretion pathway in chronic kidney disease. , Biopharmaceutics & drug disposition, 39( 7), 328- 334, Jul. 2018, https://doi.org/10.1002/bdd.2149 
9
Evaluation of the metabolic capability of primary human hepatocytes in three-dimensional cultures on microstructural plates , Biopharmaceutics and Drug Disposition, 39( 4), 187- 195, Apr. 1, 2018, https://doi.org/10.1002/bdd.2125 
10
Advances in Studies of P-Glycoprotein and Its Expression Regulators. , Biological & pharmaceutical bulletin, 41( 1), 11- 19, Jan. 2018, https://doi.org/10.1248/bpb.b17-00725 
11
Effect of Chinese Noodles Containing Calcium Alginate on Postprandial Blood Glucose Level-A Randomized, Double-blind, Crossover Clinical Trial- , Jpn. Pharmacol Ther, 46( 12), 2083- 2089, 2018,  
12
Combination Metabolomics Approach for Identifying Endogenous Substrates of Carnitine/Organic Cation Transporter OCTN1 , Pharmaceutical Research, 35( 11), 224- 224, 2018, https://doi.org/10.1007/s11095-018-2507-1 
13
Effect of Soba Noodles Containing Calcium Alginate on Postprandial Blood Glucose Level-A Randomized, Double-blind, Crossover Clinical Trial- , Jpn. Pharmacol Ther., 46( 12), 2075- 2082, 2018,  
14
Effect of Phosphate Binder on the Intestinal Absorption of Antihypertensive Drugs. , J Community Pharm. Pharm. Sci., 9( 2), 239- 245, Nov. 2017,  
15
Gastrointestinal Hormone Cholecystokinin Increases P-Glycoprotein Membrane Localization and Transport Activity in Caco-2 Cells , JOURNAL OF PHARMACEUTICAL SCIENCES, 106( 9), 2650- 2656, Sep. 2017, https://doi.org/10.1016/j.xphs.2017.04.003 
16
Snail-Induced Epithelial-to-Mesenchymal Transition Enhances P-gp-Mediated Multidrug Resistance in HCC827 Cells , JOURNAL OF PHARMACEUTICAL SCIENCES, 106( 9), 2642- 2649, Sep. 2017, https://doi.org/10.1016/j.xphs.2017.03.011 
17
Utility of human hepatocyte spheroids without feeder cells for evaluation of hepatotoxicity , JOURNAL OF TOXICOLOGICAL SCIENCES, 42( 4), 499- 507, Aug. 2017, https://doi.org/10.2131/jts.42.499 
18
Preliminary Evaluation of Three-Dimensional Primary Human Hepatocyte Culture System for Assay of Drug-Metabolizing Enzyme-Inducing Potential , BIOLOGICAL & PHARMACEUTICAL BULLETIN, 40( 7), 967- 974, Jul. 2017, https://doi.org/10.1248/bpb.b16-00885 
19
EFFECT OF THE KIWIFRUIT EXTRACT (ACTANNINE (R); ACT) ON THE INTESTINAL LIPID ABSORPTION , ANNALS OF NUTRITION AND METABOLISM, 71,  1182- 1182, 2017,  
20
Investigation of biopharmaceutical and physicochemical drug properties suitable for orally disintegrating tablets , ADMET and DMPK, 4( 4), 335- 360, Dec. 26, 2016, https://doi.org/10.5599/admet.4.4.338 
21
Investigation of biopharmaceutical and physicochemical drug properties suitable for orally disintegrating tablets , ADMET and DMPK, 4( 4), 335- 360, Dec. 26, 2016, https://doi.org/10.5599/admet.4.4.338 
22
Relationship between Physical Parameters of Various Metal Ions and Binding Affinity for Alginate , BIOLOGICAL & PHARMACEUTICAL BULLETIN, 39( 11), 1893- 1896, Nov. 2016, https://doi.org/10.1248/bpb.b16-00127 
23
Adenovirus vector infection of non-small-cell lung cancer cells is a trigger for multi-drug resistance mediated by P-glycoprotein , BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 476( 4), 183- 187, Aug. 2016, https://doi.org/10.1016/j.bbrc.2016.05.070 
24
Different regulation of P-glycoprotein function between Caco-2 and Caki-1 cells by ezrin, radixin and moesin proteins , JOURNAL OF PHARMACY AND PHARMACOLOGY, 68( 3), 361- 367, Mar. 2016, https://doi.org/10.1111/jphp.12525 
25
Possible interaction of quinolone antibiotics with peptide transporter 1 in oral absorption of peptide-mimetic drugs , BIOPHARMACEUTICS & DRUG DISPOSITION, 37( 1), 39- 45, Jan. 2016, https://doi.org/10.1002/bdd.1999 
26
Cholesterol-Lowering Effect of Calcium Alginate in Rats , BIOLOGICAL & PHARMACEUTICAL BULLETIN, 39( 1), 62- 67, Jan. 2016, https://doi.org/10.1248/bpb.b15-00503 
27
Interaction of Peptide Transporter 1 With D-Glucose and L-Glutamic Acid; Possible Involvement of Taste Receptors , JOURNAL OF PHARMACEUTICAL SCIENCES, 105( 1), 339- 342, Jan. 2016, https://doi.org/10.1016/j.xphs.2015.11.024 
28
Recommended Daily Dose of Sesame Lignans Has No Influence on Oral Absorption of P-Glycoprotein Substrates in Rats , BIOLOGICAL & PHARMACEUTICAL BULLETIN, 38( 12), 1960- 1963, Dec. 2015, https://doi.org/10.1248/bpb.b15-00392 
29
P-GLYCOPROTEIN PLAYS A KEY ROLE IN THE CONTRACTIONARY EFFECTS AGAINST BRAIN INFARCTION OF CILNIDIPINE , DRUG METABOLISM REVIEWS, 47,  280- 280, Nov. 2015,  
30
Multiple Linear Regression Analysis Indicates Association of P-Glycoprotein Substrate or Inhibitor Character with Bitterness Intensity, Measured with a Sensor , JOURNAL OF PHARMACEUTICAL SCIENCES, 104( 9), 2789- 2794, Sep. 2015, https://doi.org/10.1002/jps.24232 
31
Analysis of a child who developed abnormal neuropsychiatric symptoms after administration of oseltamivir: a case report , BMC NEUROLOGY, 15,  130- , Aug. 2015, https://doi.org/10.1186/s12883-015-0393-2 
32
Utility of human hepatocyte spheroids for evaluation of hepatotoxicity. , Fundam. Toxicol. Sci., 2( 1), 41- 48, 2015, https://doi.org/10.2131/fts.2.41 
33
Evaluation of a Thiodipeptide, L-Phenylalanyl-Psi[CS-N]-L-alanine, as a Novel Probe for Peptide Transporter 1 , DRUG METABOLISM AND PHARMACOKINETICS, 29( 6), 470- 474, Dec. 2014, https://doi.org/10.2133/dmpk.DMPK-14-RG-047 
34
Evaluation of Human Hepatocytes Cultured by Three-dimensional Spheroid Systems for Drug Metabolism , DRUG METABOLISM AND PHARMACOKINETICS, 29( 5), 373- 378, Oct. 2014, https://doi.org/10.2133/dmpk.DMPK-13-RG-105 
35
Role of P-Glycoprotein in Regulating Cilnidipine Distribution to Intact and Ischemic Brain , DRUG METABOLISM AND PHARMACOKINETICS, 29( 3), 254- 258, Jun. 2014, https://doi.org/10.2133/dmpk.DMPK-13-RG-072 
36
Luteolin and Quercetin Affect the Cholesterol Absorption Mediated by Epithelial Cholesterol Transporter Niemann-Pick C1-Like 1 in Caco-2 Cells and Rats , PLOS ONE, 9( 5), e97901- , May. 2014, https://doi.org/10.1371/journal.pone.0097901 
37
Characterization of Cesium Uptake Mediated by a Potassium Transport System of Bacteria in a Soil Conditioner , BIOLOGICAL & PHARMACEUTICAL BULLETIN, 37( 4), 604- 607, Apr. 2014, https://doi.org/10.1248/bpb.b13-00871 
38
Contribution of radixin to P-glycoprotein expression and transport activity in mouse small intestine in vivo , JOURNAL OF PHARMACEUTICAL SCIENCES, 102( 8), 2875- 2881, Aug. 2013, https://doi.org/10.1002/jps.23637 
39
Challenges of drug delivery systems that contribute to cancer chemotherapy. Foreword. , Biological & pharmaceutical bulletin, 36( 5), 691- , May. 2013, https://doi.org/10.1248/bpb.b13-f3605 
40
Alginate Enhances Excretion and Reduces Absorption of Strontium and Cesium in Rats , BIOLOGICAL & PHARMACEUTICAL BULLETIN, 36( 3), 485- 491, Mar. 2013, https://doi.org/10.1248/bpb.b12-00899 
41
Clinical Impact and Evidence of Pharmacokinetic Change by Genetic Polymorphism Preface , DRUG METABOLISM AND PHARMACOKINETICS, 28( 1), 3- 3, Feb. 2013, https://doi.org/10.2133/dmpk.DMPK-13-PF-899 
42
Clinical impact and evidence of pharmacokinetic change by genetic polymorphism. , Drug metabolism and pharmacokinetics, 28( 1), 3- , 2013,  
43
The role of inter-segmental differences in P-glycoprotein expression and activity along the rat small intestine in causing the double-peak phenomenon of substrate plasma concentration , Drug Metabolism and Pharmacokinetics, 28( 2), 98- 103, 2013, https://doi.org/10.2133/dmpk.DMPK-12-RG-005 
44
Developmental changes of brain distribution and localization of oseltamivir and its active metabolite Ro 64-0802 in rats , JOURNAL OF TOXICOLOGICAL SCIENCES, 37( 6), 1217- 1223, Dec. 2012, https://doi.org/10.2131/jts.37.1217 
45
Species difference of esterase expression and hydrolase activity in plasma , JOURNAL OF PHARMACEUTICAL SCIENCES, 101( 10), 3979- 3988, Oct. 2012, https://doi.org/10.1002/jps.23258 
46
Transport mechanisms of flavanone aglycones across Caco-2 cell monolayers and artificial PAMPA membranes , JOURNAL OF PHARMACY AND PHARMACOLOGY, 64( 1), 52- 60, Jan. 2012, https://doi.org/10.1111/j.2042-7158.2011.01374.x 
47
Effect of Knockdown of Ezrin, Radixin, and Moesin on P-Glycoprotein Function in HepG2 Cells , JOURNAL OF PHARMACEUTICAL SCIENCES, 100( 12), 5308- 5314, Dec. 2011, https://doi.org/10.1002/jps.22718 
48
Interaction of milk with the intestinal PEPT1-mediated absorption of oseltamivir in rats and humans , DRUG METABOLISM REVIEWS, 43,  202- 202, Nov. 2011,  
49
Effect of Milk on the Pharmacokinetics of Oseltamivir in Healthy Volunteers , JOURNAL OF PHARMACEUTICAL SCIENCES, 100( 9), 3854- 3861, Sep. 2011, https://doi.org/10.1002/jps.22627 
50
Segmental differences of P-glycoprotein activity and its regulatory factors in the small intestine of rats , DRUG METABOLISM REVIEWS, 43,  86- 87, May. 2011,  
51
Enhancement of Drug Solubility and Absorption by Copolymers of 2-Methacryloyloxyethyl Phosphorylcholine and n-Butyl Methacrylate , DRUG METABOLISM AND PHARMACOKINETICS, 26( 1), 79- 86, 2011, https://doi.org/10.2133/dmpk.DMPK-10-RG-070 
52
Oseltamivir (Tamiflu (TM)) Is a Substrate of PEPT1 , DRUG METABOLISM REVIEWS, 41,  114- 115, Aug. 2009,  
53
Oseltamivir (Tamiflu) Is a Substrate of Peptide Transporter 1 , DRUG METABOLISM AND DISPOSITION, 37( 8), 1676- 1681, Aug. 2009, https://doi.org/10.1124/dmd.109.026922 
54
Carnitine/Organic Cation Transporter OCTN2 (Slc22a5) Is Responsible for Renal Secretion of Cephaloridine in Mice , DRUG METABOLISM AND DISPOSITION, 37( 5), 1009- 1016, May. 2009, https://doi.org/10.1124/dmd.108.025015 
55
Evaluation of the Inhibitory Effect of Dihydropyridines on N-type Calcium Channel by Virtual Three-dimensional Pharmacophore Modeling , ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH, 59( 6), 283- 288, 2009, https://doi.org/10.1055/s-0031-1296398 
56
Oseltamivir (Tamiflu) efflux transport at the blood-brain barrier via P-glycoprotein , DRUG METABOLISM AND DISPOSITION, 36( 1), 6- 9, Jan. 2008, https://doi.org/10.1124/dmd.107.017699 
57
CONTROLLED BRAIN EXPOSURE OF OSELTAMIVIR BY DRUG TRANSPORTERS , DRUG METABOLISM REVIEWS, 40,  212- 213, 2008,  
58
Characterization of the uptake mechanism for a novel loop diuretic, M17055, in Caco-2 cells: Involvement of organic anion transporting polypeptide (OATP)-B , PHARMACEUTICAL RESEARCH, 24( 1), 90- 98, Jan. 2007, https://doi.org/10.1007/s11095-006-9127-x 
59
Oseltamivir (Tamiflu (TM)) efflux transport at the blood-brain barrier via P-glycoprotein , YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 127,  111- 112, 2007,  
60
Pharmacological profiles of the novel analgesic m58996 in rat models of persistent and neuropathic pain , JOURNAL OF PHARMACOLOGICAL SCIENCES, 102( 2), 205- 212, Oct. 2006, https://doi.org/10.1254/jphs.FP0060621 
61
Establishment of an in vitro high-throughput screening assay for detecting phospholipidosis-inducing potential , TOXICOLOGICAL SCIENCES, 90( 1), 133- 141, Mar. 2006, https://doi.org/10.1093/toxsci/kfj067 
62
Improving effect of ethyl eicosapentanoate on statin-induced rhabdomyolysis in Eisai hyperbilirubinemic rats , BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 340( 1), 215- 220, Feb. 2006, https://doi.org/10.1016/j.bbrc.2005.11.179 
63
What kinds of substrates show p-glycoprotein-dependent intestinal absorption? Comparison of verapamil with vinblastine , DRUG METABOLISM AND PHARMACOKINETICS, 21( 3), 238- 244, 2006, https://doi.org/10.2133/dmpk.21.238 
64
Eisai hyperbilirubinemic rat (EHBR) as an animal model affording high drug-exposure in toxicity studies on organic anions. , Drug metabolism and pharmacokinetics, 19( 5), 339- 351, Oct. 2004,  
65
Characterization of renal excretion mechanism for a novel diuretic, M17055, in rats , JOURNAL OF PHARMACEUTICAL SCIENCES, 93( 10), 2558- 2566, Oct. 2004, https://doi.org/10.1002/jps.20165 
66
Increased cytotoxicity of soluble Fas ligand by fusing isoleucine zipper motif , BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 322( 1), 197- 202, Sep. 2004, https://doi.org/10.1016/j.bbrc.2004.07.098 
67
Functional characterization of active transport of progesterone to adrenal cells , JOURNAL OF PHARMACY AND PHARMACOLOGY, 56( 1), 79- 84, Jan. 2004, https://doi.org/10.1211/0022357022386 
68
Studies on the Metabolic Fate of M17055, a Novel Diuretic (4): Species Difference in Metabolic Pathway and Identification of Human CYP Isoform Responsible for the Metabolism of M17055 , Drug Metabolism and Pharmacokinetics, 17( 1), 60- 74, 2002, https://doi.org/10.2133/dmpk.17.60 

 

MISC
No.Title URL, Journal, Vol( No), Start Page- End Page, Publication date 
1
創薬シリーズ 創薬研究の新潮流 ヒト肝細胞の3次元培養スフェロイドモデルの新展開 , 日本薬理学雑誌, 153( 5), 235- 241, May. 2019 
2
Examination of alternative to animal experiments for acute oral systemic toxicity test using hepatic spheroids , Annual Meeting of the Japanese Society of Toxicology, 46( 0), P- 240, 2019 
3
酸化マグネシウムとともに簡易懸濁したときのACE阻害薬の安定性 , 日本薬剤学会年会講演要旨集, 33年会,  213- 213, May. 2018 
4
HDAC阻害薬EntinostatはEMTに伴うP-gpの機能亢進を抑制する , 日本薬剤学会年会講演要旨集, 32年会,  148- 148, May. 2017 
5
ラットにおけるアルギン酸カルシウムによる血中トリグリセリドおよび体脂肪重量増加抑制効果の検討 , 日本薬学会年会要旨集, 137年会( 3), 164- 164, Mar. 2017 
6
なにをもって「薬害」とするか?「薬害」となるか? 医療関連団体へのアンケートに基づく薬害の発生要因とその定義 , 医薬品医療機器レギュラトリーサイエンス, 47( 12), 842- 847, Dec. 2016 
7
抗うつ薬のQT延長症候群発生リスクの比較検討 , 日本病院薬剤師会雑誌, 52( 9), 1148- 1152, Sep. 2016 
8
使用感を考慮したラタノプロスト点眼薬の先発医薬品と後発医薬品の比較検討 , 医療薬学, 42( 9), 651- 658, Sep. 2016 
9
三次元培養肝細胞による代謝酵素誘導評価系の構築 , The Journal of Toxicological Sciences, 41( Suppl.), S335- S335, Jun. 2016 
10
ペプチドトランスポーターによって特異的に輸送される新規がん診断プローブの設計とその有用性 , 日本薬剤学会年会講演要旨集, 31年会,  182- 182, May. 2016 
11
肺腺がん細胞へのアデノウイルス感染はAktのリン酸化を介してP-gpの発現を亢進する , 日本薬剤学会年会講演要旨集, 31年会,  220- 220, May. 2016 
12
Snail過剰発現によるEMTはHCC827細胞におけるBCRPの発現を低下させる , 日本薬剤学会年会講演要旨集, 31年会,  120- 120, May. 2016 
13
ラタノプロスト点眼液における製剤学的特性および使用感の比較検討 , 日本薬学会年会要旨集, 136年会( 4), 152- 152, Mar. 2016 
14
肺腺がん細胞へのアデノウイルス感染はP-糖タンパク質の機能を亢進させる , 日本薬学会年会要旨集, 136年会( 3), 58- 58, Mar. 2016 
15
ヒト腎臓がん細胞のP-gpおよびMRPs輸送機能における足場タンパクの関与 , 日本薬学会年会要旨集, 136年会( 4), 54- 54, Mar. 2016 
16
Pharmacokinetics of Ethyl lcosapentaenoate(EPA-E) , 食品と開発, 51( 1), 7- 10, Jan. 2016 
17
インドキシル硫酸の代償性排泄経路としての消化管分泌の関与 , 日本腎臓病薬物療法学会誌, 4( 2), S170- S170, Sep. 2015 
18
ヒト肝細胞スフェロイド培養法による薬剤性肝障害の検出におけるフィーダーレス化の検討 , The Journal of Toxicological Sciences, 40( Suppl.), S307- S307, Jun. 2015 
19
アルギン酸による重金属吸着作用の解析 , The Journal of Toxicological Sciences, 40( Suppl.), S234- S234, Jun. 2015 
20
ヒト初代肝細胞の三次元培養系を用いた薬物代謝酵素誘導の評価 , 日本薬学会年会要旨集, 135年会( 4), 74- 74, Mar. 2015 
21
消化管P-糖タンパク質の輸送機能に対するゴマリグナンの影響 , 日本薬学会年会要旨集, 135年会( 4), 76- 76, Mar. 2015 
22
エイコサペンタエン酸エチル(EPA-E)の生体内動態 , 脂質栄養学, 24( 1), 21- 32, Mar. 2015 
23
薬剤性肝障害における代謝と安全性の評価 安全性評価研究会スフェロイド(in vitro肝毒性・代謝)分科会の活動紹介 , イルシー, ( 120), 30- 35, Feb. 2015 
24
Pharmacokinetics of ethyl eicosapentaenoate (EPA-E) , Journal of Lipid Nutrition, 24( 1), 21- 32, 2015 
25
脂質の生体内ADME(吸収から排泄まで) 生理活性物質としてのω3脂肪酸の生体内動態 , 脂質栄養学, 23( 2), 139- 139, Aug. 2014 
26
アルギン酸による重金属の吸収抑制および排泄促進作用とそのメカニズムの検討 , The Journal of Toxicological Sciences, 39( Suppl.), S330- S330, Jul. 2014 
27
ヒト肝細胞スフェロイド培養法を用いた化合物曝露による肝障害の検出 , The Journal of Toxicological Sciences, 39( Suppl.), S293- S293, Jul. 2014 
28
薬物の苦味によるP-糖タンパクの基質認識性の予測 , 日本薬剤学会年会講演要旨集, 29年会,  215- 215, May. 2014 
29
Stability of the Oral Formulation in No Packaging State , Japanese Journal of Hospital Pharmacy, 40( 5), 304- 309, May. 2014 
30
補完医療におけるクスリと農科学の融合 海藻成分アルギン酸の重金属との選択的親和性を介した補完医療への応用 , 応用薬理, 85( 1-2), 42- 42, Aug. 2013 
31
In vitroを用いた創薬安全性評価とその外挿性 In vitroによる薬物代謝スクリーニングの現状と留意点 , The Journal of Toxicological Sciences, 38( Suppl.), S154- S154, Jun. 2013 
32
グルコースとPEPT1基質薬物の消化管吸収過程における相互作用 , 日本薬剤学会年会講演要旨集, 28年会,  354- 354, Apr. 2013 
33
The current impact of drug metabolism screening by in vitro , Annual Meeting of the Japanese Society of Toxicology, 40( 0),  , 2013 
34
脳虚血時におけるシルニジピンの脳内移行性に対するP糖タンパク質の関与 , 日本高血圧学会総会プログラム・抄録集, 35回,  505- 505, Sep. 2012 
35
Pharmacokinetic and pharmacogenetic analysis of a child who developed abnormal psychotic symptoms after administrations of oseltamivir , Annual Meeting of the Japanese Society of Toxicology, 39( 0), P- 76, Jul. 2012 
36
Activity of Focus Group for Cancer Treatment : The Past, Present and Future , 薬剤学 = The archives of practical pharmacy, 72( 3), 134- 137, May. 1, 2012 
37
ジェネリック医薬品の品質評価 イコサペント酸エチル製剤における官能試験および成分分析試験 , 医療薬学, 38( 4), 228- 236, Apr. 2012 
38
脳虚血時におけるシルニジピンの脳保護作用とP-糖タンパク質の関与 , 日本薬学会年会要旨集, 132年会( 4), 271- 271, Mar. 2012 
39
Quality Evaluation of Generic Drugs (1) Sensory Evaluation and Composition Analyses of Ethyl Icosapentaenoate Products , Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences), 38( 4), 228- 236, 2012 
40
Food-drug interactions , Bio industry, 28( 10), 30- 35, Oct. 2011 
41
医薬品添付文書中の薬物動態パラメータの研究 ジェネリック医薬品の生物学的同等性試験における薬物動態パラメータの試験間および試験内変動の解析 , 医療薬学, 37( 9), 543- 550, Sep. 2011 
42
Our Goal Is a Compass of Transporter Research , 薬剤学 = The archives of practical pharmacy, 71( 4), 218- 222, Jul. 1, 2011 
43
オセルタミビルおよび代謝物の脳内移行性および局在性の解析 , The Journal of Toxicological Sciences, 36( Suppl.), S137- S137, Jun. 2011 
44
小腸のP-糖タンパク発現部位差におけるradixinの寄与 , 日本薬剤学会年会講演要旨集, 26年会,  119- 119, May. 2011 
45
Pharmacokinetics Parameters in Drug Package Inserts (3):—Analysis of inter- and intra-trial variability of pharmacokinetics parameter in biological equivalence clinical studies on generic drugs— , Japanese Journal of Hospital Pharmacy, 37( 9), 543- 550, 2011 
46
ラット全小腸連続ループ法によるP-糖タンパクの発現量および活性の部位差の解析 , 薬剤学: 生命とくすり, 70( Suppl.), 119- 119, Apr. 2010 
47
消化管吸収過程における薬物とミルクのペプチドトランスポーター(PEPT1)を介した相互作用の解析 , 薬剤学: 生命とくすり, 70( Suppl.), 218- 218, Apr. 2010 
48
医薬品添付文書の薬物動態パラメータの研究 医薬品の血中濃度半減期と作用持続時間は相関するか? , 新薬と臨牀, 59( 4), 524- 532, Apr. 2010 
49
ANALYSIS OF SEGMENTAL DIFFERENCES OF P-GLYCOPROTEIN ACTIVITY IN THE SMALL INTESTINE OF RATS BY USING ALL SMALL INTESTINE CONTINUOUS CLOSED LOOPS METHOD , Abstracts of JSSX meeting, 25( 0), 145- 145, 2010 
50
PHARMACOKINETIC STUDIES OF PROTEIN, PEPTIDE AND ANTIBODY DRUGS -REGULATIONS AND OPERATIONS- , Abstracts of JSSX meeting, 25( 0), 42- 42, 2010 
51
リン脂質ポリマーを用いた薬物の吸収改善の検討 , Drug Delivery System, 24( 3), 351- 351, Jun. 2009 
52
食事由来ペプチドがヒトペプチドトランスポーターPEPT1に基質認識される薬物の消化管吸収に与える影響 , 日本栄養・食糧学会大会講演要旨集, 63回,  149- 149, May. 2009 
53
経口剤開発のstrategy ヒト吸収性の定量的予測に必要な情報・理論・手法 In vivoデータベースからのアニマルスケールアップとその問題点 , 薬剤学: 生命とくすり, 69( Suppl.), 24- 24, Apr. 2009 
54
新規溶解剤MPCポリマーを用いた医薬品の吸収改善の検討 , 薬剤学: 生命とくすり, 69( Suppl.), 208- 208, Apr. 2009 
55
フォーカスグループ(FG)活動の新しい動き , 薬剤学: 生命とくすり, 69( Suppl.), 186- 186, Apr. 2009 
56
オセルタミビルのPEPT1基質認識性と消化管吸収における食事由来ペプチドの影響 , 薬剤学: 生命とくすり, 69( Suppl.), 158- 158, Apr. 2009 
57
カルニチン/有機カチオントランスポーターOCTN2の腎臓におけるCephaloridine排出トランスポーターとしての役割 , 薬剤学: 生命とくすり, 69( Suppl.), 159- 159, Apr. 2009 
58
オセルタミビルはヒトペプチドトランスポーターPEPT1の基質である , 日本薬学会年会要旨集, 129年会( 4), 164- 164, Mar. 2009 
59
EFFECT ON THE FUNCTION OF P-GP OF KNOCKDOWN OF EZRIN, RADIXIN AND MOESIN IN HEPG2 CELLS , Abstracts of JSSX meeting, 24( 0), 196- 196, 2009 
60
服用者および調剤者の立場からの円形錠と割線入り楕円錠の比較検討 , 診療と新薬, 45( 10), 999- 1005, Oct. 2008 
61
医薬品添付文書の薬物動態パラメータの研究(1) 薬剤師を対象とした活用度・満足度調査と記載頻度 , 新薬と臨牀, 57( 9), 1468- 1475, Sep. 2008 
62
A New Pharmacology Curriculum and Pharmaceutical Science Education : Mission of the Education and Our Academy in the Future , 薬剤学 = The archives of practical pharmacy, 68( 4), 235- 238, Jul. 1, 2008 
63
抗インフルエンザ薬オセルタミビルのP糖タンパク質による中枢移行性制御 , The Journal of Toxicological Sciences, 33( Suppl.), S170- S170, Jun. 2008 
64
トランスポーター研究の新展開 創薬におけるトランスポーター研究の重要性(創薬研究者の立場から) , 薬剤学: 生命とくすり, 68( Suppl.), 26- 26, Apr. 2008 
65
日本薬剤学会へのフォーカスグループ制度の導入提案(3) 研究と臨床現場の接点から考えるフォーカスグループのテーマ , 薬剤学: 生命とくすり, 67( Suppl.), 369- 369, May. 10, 2007 
66
消化管吸収 それでもトランスポーターは働いている 消化管吸収におけるtransporterの寄与 医薬品開発における評価法と問題点 , 日本薬学会年会要旨集, 127年会( 1), 101- 101, Mar. 2007 
67
Collaboration among Physicochemical, Pharmacokinetic and Toxicological Studies in Drug Discovery Stage , Journal of Pharmaceutical Science and Technology, Japan, 66( 4), 261- 266, Jul. 1, 2006 
68
探索段階における毒性評価の効率化(3) HTS-フォスフォリピドーシス検出系に及ぼす細胞数および洗浄時間の影響 , The Journal of Toxicological Sciences, 31( Suppl.), S202- S202, Jun. 2006 
69
イコサペント酸エチル(EPA-E)のプラバスタチン誘発性横紋筋融解症に対する軽減効果 毒性動物モデルの構築とその応用 , 薬理と治療, 34( 5), 467- 478, May. 2006 
70
Contribution of intestinal transporters to drug absorption and the implications for drug discovery and development (2) : efflux transporters , Drug Delivery System, 21( 2), 142- 152, Mar. 10, 2006 
71
Contribution of intestinal transporters to drug absorption and the implications for drug discovery and development (1) : influx transporters , Drug Delivery System, 21( 2), 134- 141, Mar. 10, 2006 
72
【薬物の生体膜輸送特性とDDS】 消化管トランスポーターを意識した医薬品開発 Influx transporter , Drug Delivery System, 21( 2), 134- 141, Mar. 2006 
73
【薬物の生体膜輸送特性とDDS】 消化管トランスポーターを意識した医薬品開発 Efflux transporter , Drug Delivery System, 21( 2), 142- 152, Mar. 2006 
74
Absorption properties of vinblastine, a P-glycoprotein substrate, from various administration routes , Abstracts of Annual meeting of Japanese Society for the Study of Xenobiotics, 21( 0), 253- 253, 2006 
75
Report : Proposal to APSTJ by Future Vision-Working Group : What Must We Do Now and How Can We Do It? , Journal of Pharmaceutical Science and Technology, Japan, 65( 5), 305- 307, Sep. 1, 2005 
76
探索段階における毒性評価の効率化(1)細胞毒性試験における細胞種および試験法の検討 , 日本トキシコロジー学会学術年会プログラム・要旨集, 32回( 0), 221- 221, Jun. 2005 
77
探索段階における毒性評価の効率化(2)培養細胞を用いたHTS-フォスフォリピドーシス検出系の確立 , 日本トキシコロジー学会学術年会プログラム・要旨集, 32回( 0), 239- 239, Jun. 2005 
78
有機アニオン性薬物の消化管吸収におけるOrganic Anion Transporting Polypeptideの関与 , 薬剤学: 生命とくすり, 65( Suppl.), 68- 68, Mar. 2005 
79
新規ループ利尿薬M17055のCaco-2細胞における取込み機構と有機アニオントランスポーターOATP-Bの寄与 , 日本薬学会年会要旨集, 124年会( 4), 71- 71, Mar. 2004 
80
INVOLVEMENT OF ORGANIC ANION TRANSPORTING POLYPEPTIDE (OATP) FAMILY IN THE UPTAKE OF A NOVEL LOOP DIURETIC M17055 BY SMALL INTESTINAL EPITHELIAL CELLS , Abstracts of Annual meeting of Japanese Society for the Study of Xenobiotics, 19( 0), 134- 134, 2004 
81
DOES P-GLYCOPROTEIN AFFECT GASTRIC ABSORPTION OF DRUGS? , Abstracts of Annual meeting of Japanese Society for the Study of Xenobiotics, 19( 0), 34- 34, 2004 
82
高力価可溶型FasリガンドによるC6髄膜播種モデルの治療 , Brain Tumor Pathology, 19( Suppl.), 105- 105, May. 2002 
83
Comparison of the Pharmacokinetics of [^3H]Ara-A (Vidarabine) Cream versus Ointment Formulations : The Concentration of Radioactivity in the Epidermis after Topical Dermal Application of Ara-A to Male Rats , 薬剤学 = The archives of practical pharmacy, 61( 3), 79- 85, Sep. 20, 2001 
84
[3H]Ara-Aクリーム及び[3H]Ara-A軟膏の生体内動態の比較 ラット経皮投与後の表皮内放射能濃度推移 , 薬剤学: 生命とくすり, 61( 3), 79- 85, Sep. 2001 
85
新規利尿薬M17055の生体内動態(第1報) [14C]M17055単回静脈内投与時のラット及びイヌにおける血中濃度及び排泄 , 薬物動態, 16( 4), 304- 313, Aug. 2001 
86
[3H]Ara-Aクリームの生体内動態 ラット経皮投与後の表皮内放射能濃度推移 , 薬剤学: 生命とくすり, 61( Suppl.), 208- 208, Mar. 5, 2001 
87
抗うつ薬マレイン酸セチプチリンのヒト肝チトクロームP450活性に対する影響 マレイン酸フルボキサミンとの比較 , 薬理と治療, 29( 1), 45- 50, Jan. 2001 
88
Studies on the Metabolic Fate of M17055, a Novel Diuretic. (1): Plasma Concentration and Excretion of Radioactivity in Rat and Dog after a Single Intravenous Administration of [14C]M17055. , Drug Metabolism and Pharmacokinetics, 16( 4), 304- 313, 2001 
89
薬剤学,製剤学,病院薬学 新しい有機カチオン輸送担体OCTNはカルニチンも運ぶ!? , ファルマシア, 36( 8), 725- 726, Aug. 2000 
90
消化管アニオン交換輸送系の基質認識・輸送特性 , 薬物動態, 13( Suppl.), S217- S217, Oct. 1998 
91
Ulinastatinのラット腎臓における代謝 , 日本薬学会年会要旨集, 118年会( 4), 42- 42, Mar. 1998 
92
消化管におけるモノカルボン酸の立体選択的輸送特性 , 薬物動態, 12( Suppl.), 196- 196, Oct. 9, 1997 
93
MOKECULAR CHARACTERIZATION OF INTESTINAL ABSORPTION FOR MONOCARBOXYLIC ACIDS MEDIATED BY PROTON-COUPLED TRANSPORTER , 薬物動態 = Xenobiotic metabolism and disposition, 10,  72- 75, Oct. 18, 1995 
94
Fractal理論による担体介在型膜透過機構の解析 , 薬物動態, 10( Suppl.), 284- 284, Oct. 18, 1995 
95
MOLECULAR CHARACTERIZATION OF INTESTINAL ABSORPTION FOR MONOCARBOXYLIC ACIDS MEDIATED BY PROTON-COUPLED TRANSPORTER , Drug Metabolism and Pharmacokinetics, 10( 0), 72- 75, 1995 
96
Studies on the Metabolic Fate of Miconazole. (3). The Absorption, Distribution and Metabolism after Application of Miconazole to Oral Mucosa of Rats. , Drug Metabolism and Pharmacokinetics, 8( 3), 323- 331, 1993 
97
Ulinastatinのウサギにおける関節腔内投与後の生体内動態 , 薬物代謝と薬効・毒性シンポジウム講演要旨集, 21回,  67- 68, Sep. 1990 
98
Studies on the metabolic fate of ulinastatin (1): Pharmacokinetics in rats, mice and rabbits following a single intravenous dose. , Drug Metabolism and Pharmacokinetics, 5( 5), 739- 753, 1990 
99
METABOLISM OF ETHYL EICOSAPENTAENOATE (EPA-E) IN RATS AND EFFECT OF ITS METABOLITES ON ELLAGIC ACID-INDUCED THROMBUS FORMATION IN THE STENOSED FEMORAL-ARTERY OF RABBITS , CHEMICAL & PHARMACEUTICAL BULLETIN, 36( 6), 2158- 2167, Jun. 1988 
100
METABOLISM OF ETHYL EICOSAPENTAENOATE (EPA-E) IN RATS AND EFFECT OF ITS METABOLITES ON ELLAGIC ACID-INDUCED THROMBUS FORMATION IN THE STENOSED FEMORAL-ARTERY OF RABBITS , CHEMICAL & PHARMACEUTICAL BULLETIN, 36( 6), 2158- 2167, Jun. 1988 
101
ラットにおけるethyl eicosapentaenoateの代謝ならびにウサギの狭窄大腿動脈におけるellagic acid誘発血栓形成に及ぼすその代謝産物の効果 , Chemical & Pharmaceutical Bulletin, 36( 6), 2158- 2167, Jun. 1988 
102
エイコサペンタエン酸エチル(EPA-E)とその代謝物の肝薬物代謝酵素系及び脂肪酸代謝酵素系へ及ぼす影響 , 薬学雑誌, 108( 3), 239- 245, Mar. 1988 
103
エイコサペンタエン酸エチル(EPA-E)のラットおよびイヌにおける生体内動態 , 薬物動態, 2( 6), 683- 702, Dec. 1987 
104
Studies on the gastrointestinal absorption of ethyl eicosapentaenoate(EPA-E) in rats. , Drug Metabolism and Pharmacokinetics, 2( 6), 673- 681, 1987 
105
Studies on the metabolic disposition of ethyl eicosapentaenoate(EPA-E) in rats and dogs. , Drug Metabolism and Pharmacokinetics, 2( 6), 683- 702, 1987 
106
2-チオウリジン誘導体のアゾジベンゾイルによる脱硫反応 , 日本化学会講演予稿集, 43春季年会( II), 755- 755, Mar. 1981