Takasaki University of Health and Welfare

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SUTO Yutaka

Profile Research field Research achievement Educational achievement Management achievement Social contribution achievement

 

Published Papers
No.Title URL, Journal, Vol( No), Start Page- End Page, Publication date, DOI 
1
Hexylsilane-mediated direct amidation of amino acids with a catalytic amount of 1,2,4-triazole. , Organic & biomolecular chemistry, 22( 4), 703- 707, Jan. 24, 2024, https://doi.org/10.1039/d3ob01722b 
2
In Vitro and in Vivo Study of a Photostable Quinone Compound with Enhanced Therapeutic Efficacy against Chagas Disease. , Chemical & pharmaceutical bulletin, 72( 4), 389- 392, 2024, https://doi.org/10.1248/cpb.c24-00116 
3
A novel derivative (GTN024) from a natural product, komaroviquinone, induced the apoptosis of high-risk myeloma cells via reactive oxygen production and ER stress. , Biochemical and biophysical research communications, 505( 3), 787- 793, Nov. 2018, https://doi.org/10.1016/j.bbrc.2018.09.177 
4
Synthesis and biological evaluation of the natural product komaroviquinone and related compounds aiming at a potential therapeutic lead compound for high-risk multiple myeloma , BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 27( 19), 4558- 4563, Oct. 2017, https://doi.org/10.1016/j.bmcl.2017.08.054 
5
Synthesis and biological evaluation of quinones derived from natural product komaroviquinone as anti-Trypanosoma cruzi agents , BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 25( 15), 2967- 2971, Aug. 2015, https://doi.org/10.1016/j.bmcl.2015.05.022 
6
JmjC enzyme KDM2A is a regulator of rRNA transcription in response to starvation , EMBO JOURNAL, 29( 9), 1510- 1522, May. 2010, https://doi.org/10.1038/emboj.2010.56 
7
Convenient method for the addition of disulfides to alkenes , BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 17( 22), 6197- 6201, Nov. 2007, https://doi.org/10.1016/j.bmcl.2007.09.021 
8
Catalytic enantioselective Mannich-type reactions of ketoimines , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 129( 3), 500- 501, Jan. 2007, https://doi.org/10.1021/ja068226a 
9
Cu(I)-catalyzed direct enantioselective cross aldol-type reaction of acetonitrile , ORGANIC LETTERS, 7( 17), 3757- 3760, Aug. 2005, https://doi.org/10.1021/ol051423e 
10
Direct catalytic aldol-type reactions using RCH2CN , ORGANIC LETTERS, 5( 17), 3147- 3150, Aug. 2003, https://doi.org/10.1021/ol035206u 
11
A new method for the catalytic aldol reaction to ketones , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 125( 19), 5644- 5645, May. 2003, https://doi.org/10.1021/ja034993n 
12
Dramatic switching of protein kinase C agonist/antagonist activity by modifying the 12-ester side chain of phorbol esters , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 124( 36), 10658- 10659, Sep. 2002, https://doi.org/10.1021/ja027048s 

 

MISC
No.Title URL, Journal, Vol( No), Start Page- End Page, Publication date 
1
komaroviquinoneという天然物由来の新規化合物がin vivoにおいて抗MM活性を示す(Novel compound derived from natural products, komaroviquinone, showed anti-MM activity in vivo) , 日本癌学会総会記事, 78回,  E- 1051, Sep. 2019 
2
Tofacitinib合成中間体の立体選択的合成法の検討 , 日本薬学会年会要旨集, 138年会( 2), 174- 174, Mar. 2018 
3
天然物コマロビキノン及び関連化合物の骨髄腫細胞に対する抗腫瘍活性の評価 , 日本薬学会年会要旨集, 138年会( 2), 189- 189, Mar. 2018 
4
Komaroviquinone-Derivatives, Revealed Anti-Tumor Effect on High-Risk Multiple Myeloma Cells In Vitro as Well as In Vivo , BLOOD, 128( 22),  , Dec. 2016 
5
シャーガス病治療薬の開発を志向したキノン誘導体の合成と活性評価 , 日本薬学会年会要旨集, 135年会( 2), 245- 245, Mar. 2015 
6
A concise synthesis of Tamiflu: third generation route via the Diels-Alder reaction and the Curtius rearrangement , Tetrahedron Letters, 48,  1403- 1406, Feb. 19, 2007 
7
New chiral bis(diphenylphospholane) ligands: Design, synthesis, and application to catalytic enantioselective aldol reaction to ketones , Tetrahedron Letters, 46,  4325- 4329, Jun. 20, 2005