Takasaki University of Health and Welfare

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OKAMOTO Kengo

Profile Research field Research achievement Educational achievement Management achievement Social contribution achievement

 

Published Papers
No.Title URL, Journal, Vol( No), Start Page- End Page, Publication date, DOI 
1
KDM2A-dependent reduction of rRNA transcription on glucose starvation requires HP1 in cells, including triple-negative breast cancer cells , Oncotarget, 10( 46), 4743- 4760, Jul. 2019, https://doi.org/10.18632/oncotarget.27092 
2
SF-KDM2A binds to ribosomal RNA gene promoter, reduces H4K20me3 level, and elevates ribosomal RNA transcription in breast cancer cells , INTERNATIONAL JOURNAL OF ONCOLOGY, 50( 4), 1372- 1382, Apr. 2017, https://doi.org/10.3892/ijo.2017.3908 
3
Mild Glucose Starvation Induces KDM2A-Mediated H3K36me2 Demethylation through AMPK To Reduce rRNA Transcription and Cell Proliferation , MOLECULAR AND CELLULAR BIOLOGY, 35( 24), 4170- 4184, Dec. 2015, https://doi.org/10.1128/MCB.00579-15 
4
A CxxC Domain That Binds to Unmethylated CpG Is Required for KDM2A to Control rDNA Transcription , YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 135( 1), 11- 21, Jan. 2015, https://doi.org/10.1248/yakushi.14-00202-2 
5
CxxC-ZF Domain Is Needed for KDM2A to Demethylate Histone in rDNA Promoter in Response to Starvation , CELL STRUCTURE AND FUNCTION, 39( 1), 79- 92, 2014, https://doi.org/10.1247/csf.13022 
6
Ablation of mina53 in mice reduces allergic response in the airways , Cell Structure and Function, 38( 2), 155- 167, 2013, https://doi.org/10.1247/csf.13006 
7
JmjC enzyme KDM2A is a regulator of rRNA transcription in response to starvation , EMBO JOURNAL, 29( 9), 1510- 1522, May. 2010, https://doi.org/10.1038/emboj.2010.56 
8
Dysfunction of Mitochondrial ATP Production As a Target for Personalized Cancer Therapy , Current Pharmacogenomics and Personalized Medicine, 7( 1), 27- 39, Mar. 1, 2009, https://doi.org/10.2174/187569209787582358 
9
Expression of the TAF4b gene is induced by MYC through a non-canonical, but not canonical, E-box which contributes to its specific response to MYC , INTERNATIONAL JOURNAL OF ONCOLOGY, 33( 6), 1271- 1280, Dec. 2008, https://doi.org/10.3892/ijo_00000118 
10
Mechanism for inactivation of the mitotic inhibitory kinase Wee1 at M phase , PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 104( 10), 3753- 3758, Mar. 2007, https://doi.org/10.1073/pnas.0607357104 
11
M-r 25 000 protein, a substrate for protein serine/threonine kinases, is identified as a part of Xenopus laevis vitellogenin B1 , DEVELOPMENT GROWTH & DIFFERENTIATION, 45( 3), 283- 294, Jun. 2003, https://doi.org/10.1046/j.1524-4725.2003.696.x 
12
The existence of two distinct Wee1 isoforms in Xenopus: implications for the developmental regulation of the cell cycle , EMBO JOURNAL, 21( 10), 2472- 2484, May. 2002,  
13
Absence of Wee1 ensures the meiotic cell cycle in Xenopus oocytes , GENES & DEVELOPMENT, 14( 3), 328- 338, Feb. 2000,  

 

MISC
No.Title URL, Journal, Vol( No), Start Page- End Page, Publication date 
1
メトホルミンによるKDM2A依存的なrRNA転写抑制は栄養素により調節される , 日本生化学会大会(Web), 90th,  ROMBUNNO.2P‐0579 (WEB ONLY)- , 2017 
2
KDM2Aはマイルドなグルコース飢餓時にAMPKシグナル経路を介してrRNA転写と細胞増殖を調節する , 日本生化学会大会(Web), 88th,  2P0664 (WEB ONLY)- , 2015 
3
非メチルCpGを認識するCxxCドメインはヒストン脱メチル化酵素KDM2AのrDNA転写調節に必要である , 日本薬学会年会要旨集(CD-ROM), 134th,  ROMBUNNO.S40-2- , 2014 
4
脱メチル化酵素KDM2A(Lysine‐specific demethylase2A)によるリボソームRNA転写抑制機構の解析 , 日本分子生物学会年会プログラム・要旨集(Web), 36th,  1P-0252 (WEB ONLY)- , 2013 
5
mina53遺伝子欠損マウスではアレルギー性気道炎症が減弱する , アレルギー, 61( 9/10), 1438- , Oct. 25, 2012 
6
Nucleoli and Ribosomal RNA Transcription , 細胞工学, 31( 8), 901- 908, 2012 
7
脱メチル化酵素KDM2A(Lysine‐specific demethylase2A)によるリボソームRNA転写抑制機構の解析 , 日本分子生物学会年会プログラム・要旨集(Web), 34th,  4P-0060 (WEB ONLY)- , 2011 
8
ヒストン脱メチル化酵素KDM2A(Jumonji‐C containing histone demethylase 1A)はリボソームRNA転写を抑制する , 日本薬学会年会要旨集, 130th( 3), 140- , Mar. 5, 2010 
9
脱メチル化酵素KDM2A(jumonji‐C containing histone demethylase1A)によるリボソームRNA転写の調節 , 生化学, ,  ROMBUNNO.3T2-4- , 2010 
10
インスリン様成長因子によるクロマチン状態の調節を介したリボソーム合成調節機構の解明 , 成長科学協会研究年報, ( 32), 181- 183, Aug. 1, 2009 
11
脱メチル化酵素KDM2Aは飢餓状態でリポソームRNA転写を抑制する。 , 日本分子生物学会年会講演要旨集, 32nd( Vol.4), 98- , 2009 
12
ヒストンメチル化修飾とリボソームRNA転写 , 日本薬学会関東支部大会講演要旨集, 52nd,  91- , Oct. 4, 2008 

 

Research Grants & Projects
No.Offer organization, System name, Title, Fund classification, Date 
1
, JST Basic Research Programs (Core Research for Evolutional Science and Technology :CREST), Regulation mechanism of Wee1 at M-phaseˇ, competitive_research_funding,  1998 - NOW