Takasaki University of Health and Welfare

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SHIMOKAWA Noriaki

Profile Research field Research achievement Educational achievement Management achievement Social contribution achievement

 

Published Papers
No.Title URL, Journal, Vol( No), Start Page- End Page, Publication date, DOI 
1
Maternal prolactin levels during late pregnancy and nurturing behavior of offspring in mice. , Developmental psychobiology, 64( 3), e22264- , Mar. 2022, https://doi.org/10.1002/dev.22264 
2
EID1 suppresses lipid accumulation by inhibiting the expression of GPDH in 3T3-L1 preadipocytes. , Journal of cellular physiology, 235( 10), 6725- 6735, Oct. 2020, https://doi.org/10.1002/jcp.29567 
3
Upregulated miR-224-5p suppresses osteoblast differentiation by increasing the expression of Pai-1 in the lumbar spine of a rat model of congenital kyphoscoliosis. , Molecular and cellular biochemistry, 475( 1-2), 53- 62, Aug. 3, 2020, https://doi.org/10.1007/s11010-020-03859-8 
4
The retinol-retinoic acid metabolic pathway is impaired in the lumbar spine of a rat model of congenital kyphoscoliosis. , Journal of cellular biochemistry, ,   , May. 2019, https://doi.org/10.1002/jcb.28762 
5
Changes in biomarker levels and myofiber constitution in rat soleus muscle at different exercise intensities. , Molecular and cellular biochemistry, 458( 1-2), 79- 87, Apr. 2019, https://doi.org/10.1007/s11010-019-03532-9 
6
Early-life stress induces cognitive disorder in middle-aged mice , Neurobiology of Aging, 64,  139- 146, Apr. 1, 2018, https://doi.org/10.1016/j.neurobiolaging.2017.12.021 
7
Maternal prolactin during late pregnancy is important in generating nurturing behavior in the offspring , PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 114( 49), 13042- 13047, Dec. 2017, https://doi.org/10.1073/pnas.1621196114 
8
Differential neurotoxic effects of in utero and lactational exposure to hydroxylated polychlorinated biphenyl (OH-PCB 106) on spontaneous locomotor activity and motor coordination in young adult male mice , JOURNAL OF TOXICOLOGICAL SCIENCES, 42( 4), 407- 416, Aug. 2017, https://doi.org/10.2131/jts.42.407 
9
Dysfunction of the Cerebral Glucose Transporter SLC45A1 in Individuals with Intellectual Disability and Epilepsy , AMERICAN JOURNAL OF HUMAN GENETICS, 100( 5), 824- 830, May. 2017, https://doi.org/10.1016/j.ajhg.2017.03.009 
10
The change in thyroid hormone signaling by altered training intensity in male rat skeletal muscle , ENDOCRINE JOURNAL, 63( 8), 727- 738, Aug. 2016, https://doi.org/10.1507/endocrj.EJ16-0126 
11
Regulation of human subcutaneous adipocyte differentiation by EID1 , JOURNAL OF MOLECULAR ENDOCRINOLOGY, 56( 2), 113- 122, Feb. 2016, https://doi.org/10.1530/JME-15-0148 
12
The Trk family of neurotrophin receptors is downregulated in the lumbar spines of rats with congenital kyphoscoliosis , MOLECULAR AND CELLULAR BIOCHEMISTRY, 412( 1-2), 11- 18, Jan. 2016, https://doi.org/10.1007/s11010-015-2603-z 
13
Aberrant Cerebellar Development of Transgenic Mice Expressing Dominant-Negative Thyroid Hormone Receptor in Cerebellar Purkinje Cells , ENDOCRINOLOGY, 156( 4), 1565- 1576, Apr. 2015, https://doi.org/10.1210/en.2014-1079 
14
Downregulation of receptor tyrosine kinases through ubiquitination: analysis by immunodetection. , Methods in molecular biology (Clifton, N.J.), 1233,  121- 133, 2015, https://doi.org/10.1007/978-1-4939-1789-1_12 
15
Early-life-stress affects the homeostasis of glutamatergic synapses , EUROPEAN JOURNAL OF NEUROSCIENCE, 40( 11), 3627- 3634, Dec. 2014, https://doi.org/10.1111/ejn.12728 
16
Lactational Exposure to Hydroxylated Polychlorinated Biphenyl (OH-PCB 106) Causes Hyperactivity in Male Rat Pups by Aberrant Increase in Dopamine and its Receptor , ENVIRONMENTAL TOXICOLOGY, 29( 8), 876- 883, Aug. 2014, https://doi.org/10.1002/tox.21815 
17
Possible involvement of IGF-1 signaling on compensatory growth of the infraspinatus muscle induced by the supraspinatus tendon detachment of rat shoulder , Physiological Reports, 2( 1), e00197- , 2014, https://doi.org/10.1002/phy2.197 
18
Altered Cerebellum Development and Dopamine Distribution in a Rat Genetic Model with Congenital Hypothyroidism , JOURNAL OF NEUROENDOCRINOLOGY, 26( 3), 164- 175, 2014, https://doi.org/10.1111/jne.12135 
19
The effect of low dose lipopolysaccharide on thyroid hormone-regulated actin cytoskeleton modulation and type 2 iodothyronine deiodinase activity in astrocytes , ENDOCRINE JOURNAL, 60( 11), 1221- 1230, Nov. 2013,  
20
Interaction of silencing mediator for retinoid and thyroid receptors with steroid and xenobiotic receptor on multidrug resistance 1 promoter , LIFE SCIENCES, 92( 17-19), 911- 915, May. 2013, https://doi.org/10.1016/j.lfs.2013.03.007 
21
Critical role of the astrocyte for functional remodeling in contralateral hemisphere of somatosensory cortex after stroke. , The Journal of neuroscience : the official journal of the Society for Neuroscience, 33( 11), 4683- 92, Mar. 13, 2013, https://doi.org/10.1523/JNEUROSCI.2657-12.2013 
22
Alterations of biochemical marker levels and myonuclear numbers in rat skeletal muscle after ischemia-reperfusion , Molecular and Cellular Biochemistry, 373( 1-2), 11- 18, Jan. 2013, https://doi.org/10.1007/s11010-012-1470-0 
23
Suppression of thyroid hormone receptor-mediated transcription and disruption of thyroid hormone-induced cerebellar morphogenesis by the polybrominated biphenyl mixture, BP-6 , NEUROTOXICOLOGY, 32( 4), 400- 409, Aug. 2011, https://doi.org/10.1016/j.neuro.2011.02.008 
24
Ligand-induced downregulation of TrkA is partly regulated through ubiquitination by Cbl , FEBS LETTERS, 585( 12), 1741- 1747, Jun. 2011, https://doi.org/10.1016/j.febslet.2011.04.056 
25
Brain-derived neurotrophic factor (BDNF) ameliorates the suppression of thyroid hormone-induced granule cell neurite extension by hexabromocyclododecane (HBCD) , Neuroscience Letters, 493( 1-2), 1- 7, Apr. 8, 2011, https://doi.org/10.1016/j.neulet.2011.01.062 
26
1,2,5,6,9,10-αHexabromocyclododecane (HBCD) impairs thyroid hormone-induced dendrite arborization of Purkinje cells and suppresses thyroid hormone receptor-mediated transcription , Cerebellum, 10( 1), 22- 31, Mar. 2011, https://doi.org/10.1007/s12311-010-0218-1 
27
Disruption of Thyroid Hormone Receptor-Mediated Transcription and Thyroid Hormone-Induced Purkinje Cell Dendrite Arborization by Polybrominated Diphenyl Ethers , ENVIRONMENTAL HEALTH PERSPECTIVES, 119( 2), 168- 175, Feb. 2011, https://doi.org/10.1289/ehp.1002065 
28
CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice , EMBO JOURNAL, 29( 14), 2421- 2432, Jul. 2010, https://doi.org/10.1038/emboj.2010.120 
29
Hydroxylated PCB induces Ca2+ oscillations and alterations of membrane potential in cultured cortical cells , JOURNAL OF APPLIED TOXICOLOGY, 30( 4), 334- 342, May. 2010, https://doi.org/10.1002/jat.1501 
30
The Effect of Hydroxylated Polychlorinated Biphenyl (OH-PCB) on Thyroid Hormone Receptor (TR)-mediated Transcription through Native-Thyroid Hormone Response Element (TRE) , INDUSTRIAL HEALTH, 48( 1), 115- 118, Jan. 2010,  
31
Retinoic Acid Receptor-Related Orphan Receptor Alpha-Enhanced Thyroid Hormone Receptor-Mediated Transcription Requires Its Ligand Binding Domain Which Is Not, by Itself, Sufficient: Possible Direct Interaction of Two Receptors , THYROID, 19( 8), 893- 898, Aug. 2009, https://doi.org/10.1089/thy.2008.0336 
32
Activation of Aromatase Expression by Retinoic Acid Receptor-related Orphan Receptor (ROR) alpha in Breast Cancer Cells IDENTIFICATION OF A NOVEL ROR RESPONSE ELEMENT , JOURNAL OF BIOLOGICAL CHEMISTRY, 284( 26), 17711- 17719, Jun. 2009, https://doi.org/10.1074/jbc.M109.009241 
33
The role of thyroid hormone in developing cerebellum , CEREBELLUM, 7( 3), 499- 500, Sep. 2008,  
34
Augmentation of estrogen receptor-mediated transcription by steroid and xenobiotic receptor , Endocrine, 33( 3), 305- 316, Jun. 2008, https://doi.org/10.1007/s12020-008-9091-9 
35
Augmentation of estrogen receptor-mediated transcription by steroid and xenobiotic receptor , ENDOCRINE, 33( 3), 305- 316, Jun. 2008, https://doi.org/10.1007/s12020-008-9091-9 
36
Abnormalities of vertebral formation and Hox expression in congenital kyphoscoliotic rats , MOLECULAR AND CELLULAR BIOCHEMISTRY, 312( 1-2), 193- 199, May. 2008, https://doi.org/10.1007/s11010-008-9734-4 
37
Low-dose morphine induces hyperalgesia through activation of G(alpha s), protein kinase C, and L-type Ca2+ channels in rats , JOURNAL OF NEUROSCIENCE RESEARCH, 86( 2), 471- 479, Feb. 2008, https://doi.org/10.1002/jnr.21489 
38
The Effect of Retinoic Acid Receptor-Related Orphan Nuclear Receptor α on Apo AI and Malic Enzyme Gene Expression. , Proceedings of Annual Meeting of the Physiological Society of Japan, 2008( 0), 137- 137, 2008, https://doi.org/10.14849/psjproc.2008.0_137_3 
39
Alteration of cerebellar neurotropin messenger ribonucleic acids and the lack of thyroid hormone receptor augmentation by staggerer-type retinoic acid receptor-related orphan receptor-alpha mutation , ENDOCRINOLOGY, 148( 4), 1745- 1753, Apr. 2007, https://doi.org/10.1210/en.2006-1131 
40
Tamoxifen activates CYP3A4 and MDR1 genes through steroid and xenobiotic receptor in breast cancer cells , ENDOCRINE, 30( 3), 261- 268, Dec. 2006,  
41
Tamoxifen activates CYP3A4 and MDR1 genes through steroid and xenobiotic receptor in breast cancer cells , Endocrine, 30( 3), 261- 268, Dec. 2006, https://doi.org/10.1007/s12020-006-0003-6 
42
The adrenal gland is a source of stress-induced circulating IL-18 , JOURNAL OF NEUROIMMUNOLOGY, 172( 1-2), 59- 65, Mar. 2006, https://doi.org/10.1016/j.jneuroim.2005.11.001 
43
Low dose hydroxylated PCB induces c-Jun expression in PC12 cells , NEUROTOXICOLOGY, 27( 2), 176- 183, Mar. 2006, https://doi.org/10.1016/j.neuro.2005.09.005 
44
Gene expression and signaling pathways by extracellular acidification , ARTERIAL CHEMORECEPTORS, 580,  267- 274, 2006, https://doi.org/10.1007/0-387-31311-7_42 
45
Extracellular acidification enhances DNA binding activity of MafG-FosB heterodimer , JOURNAL OF CELLULAR PHYSIOLOGY, 205( 1), 77- 85, Oct. 2005, https://doi.org/10.1002/jcp.20369 
46
Molecular responses to acidosis of central chemosensitive neurons in brain , CELLULAR SIGNALLING, 17( 7), 799- 808, Jul. 2005, https://doi.org/10.1016/j.cellsig.2005.01.004 
47
Polychlorinated biphenyl (PCB) alters acid-sensitivity of cultured neurons derived from the medulla oblongata , INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 37( 7), 1368- 1374, Jul. 2005, https://doi.org/10.1016/j.biocel.2005.02.003 
48
Phosphorylation of JNK is involved in regulation of H+-induced c-Jun expression , CELLULAR SIGNALLING, 16( 6), 723- 729, Jun. 2004, https://doi.org/10.1016/j.cellsig.2003.11.005 
49
Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites , JOURNAL OF CELL SCIENCE, 117( 12), 2557- 2568, May. 2004, https://doi.org/10.1242/jcs.01148 
50
Past-A, a novel proton-associated sugar transporter, regulates glucose homeostasis in the brain , JOURNAL OF NEUROSCIENCE, 22( 21), 9160- 9165, Nov. 2002,  
51
Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors , PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 99( 19), 12191- 12196, Sep. 2002, https://doi.org/10.1073/pnas.19462299 
52
MafG-2 is a novel Maf protein that is expressed by stimulation of extracellular H+ , CELLULAR SIGNALLING, 13( 11), 835- 839, Nov. 2001,  
53
Molecular cloning of Rhombex-40 a transmembrane protein from the ventral medullary surface of the rat brain by differential display , LIFE SCIENCES, 66( 22), 2183- 2191, Apr. 2000,  
54
Cloning of MafG homologue from the rat brain by differential display and its expression after hypercapnic stimulation , MOLECULAR AND CELLULAR BIOCHEMISTRY, 203( 1-2), 135- 141, Jan. 2000,  
55
Extracellular H stimulates the expression of c-fos/c-jun mRNA through Ca2+/calmodulin in PC12 cells , Cell Signal, 10( 7), 499- 503, Jul. 1998, https://doi.org/10.1016/S0898-6568(97)00176-9 
56
In vitro study of H+-sensitive neurons in the ventral medullary surface of neonate rats , BRAIN RESEARCH, 777( 1-2), 95- 102, Nov. 1997,  
57
SPECIFIC SPECIES AND TISSUE DIFFERENCES FOR THE GENE-EXPRESSION OF CALCIUM-BINDING PROTEIN REGUCALCIN , MOLECULAR AND CELLULAR BIOCHEMISTRY, 143( 1), 67- 71, Feb. 1995,  
58
EXPRESSION OF HEPATIC CALCIUM-BINDING PROTEIN REGUCALCIN MESSENGER-RNA IS DECREASED BY PHENOBARBITAL ADMINISTRATION IN RATS , MOLECULAR AND CELLULAR BIOCHEMISTRY, 141( 1), 15- 19, Dec. 1994,  
59
EXPRESSION OF CALCIUM-BINDING PROTEIN REGUCALCIN MESSENGER-RNA IN RAT-LIVER IS STIMULATED BY CALCITONIN - THE HORMONAL EFFECT IS MEDIATED THROUGH CALCIUM , MOLECULAR AND CELLULAR BIOCHEMISTRY, 136( 1), 43- 48, Jul. 1994,  
60
EXPRESSION OF HEPATIC CALCIUM-BINDING PROTEIN REGUCALCIN MESSENGER-RNA IS MEDIATED THROUGH CA-2+ CALMODULIN IN RAT-LIVER , FEBS LETTERS, 316( 1), 79- 84, Jan. 1993,  
61
CALCIUM ADMINISTRATION STIMULATES THE EXPRESSION OF CALCIUM-BINDING PROTEIN REGUCALCIN MESSENGER-RNA IN RAT-LIVER , FEBS LETTERS, 305( 2), 151- 154, Jun. 1992,  

 

MISC
No.Title URL, Journal, Vol( No), Start Page- End Page, Publication date 
1
Effect of oral administration of thyroxine on cerebellar function in congenital hypothyroid(rdw)rat , JOURNAL OF PHYSIOLOGICAL SCIENCES, 63,  S214- S214, 2013 
2
Interaction of full length ROR? to augment TR-mediated transcription. , Thyroid., 19,  893- 898, 2009 
3
INTRACELLULAR TRAFFICKING OF THE GENERAL COACTIVATOR SYT , JOURNAL OF PHYSIOLOGICAL SCIENCES, 59,  225- 225, 2009 
4
Current progress in molecular responses to acidosis in the central nervous system. , Current Medicinal Chemistry-Central Nervous System Agents, 5,  141- 149, 2005 

 

Research Grants & Projects
No.Offer organization, System name, Title, Fund classification, Date 
1
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Elucidation of the mechanism of parental abandonment caused by perinatal stress, ,  Apr. 2023 - Mar. 2027 
2
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Epigenetic modulation by chemical substances on thyroid hormone-mediated brain development., ,  Apr. 2018 - Mar. 2022 
3
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Analysis of the fetal/uterine environment on nurturing behavior in the next generation: understanding the causes of neglect and its recovery, ,  Apr. 2017 - Mar. 2020 
4
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Comprehensive analysis of gene expression in congenital scoliosis, ,  Apr. 2016 - Mar. 2019 
5
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Establishment of disease due to CIN85 abnormality: Analysis of pathology and molecular variation of hyperactivity, maternal neglect and mental retardation, ,  Apr. 2014 - Mar. 2017 
6
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, A novel pathway of the differenciation of Beige cells - analisis of adipocyte specific EID1-overexpressed mice, ,  Apr. 2014 - Mar. 2016 
7
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Comprehensive analysis of gene expression in the spine of congenital kyphoscoliosis obtained using DNA microarrays, ,  Apr. 2013 - Mar. 2016 
8
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Effects of environmental factors on small lipophilic hormone-mediated development of brain function, ,  Apr. 2013 - Mar. 2017 
9
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Whether hyperactivity disorder is genetic diseases or not? The establishment of gene diagnosis for hyperactivity disorder due to CIN85 abnormality., ,  Apr. 2012 - Mar. 2015 
10
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Crosstalk between nuclear receptor and transcription cofactor on brain development and its modulation by environmental chemicals., ,  2009 - 2012 
11
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Analysis of behavior disorder and the deficient rescue of CIN85 knockout mouse that shows hyperactivity and rearing neglect to newborns, ,  2009 - 2011 
12
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Analysis of behavioral quantity by the loss of function of CIN85 related to receptor endocytosis, ,  2006 - 2008 
13
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Molecular mechanisms generating a critical period of thyroid hormone action on brain development and its modulation by environmental chemicals, ,  2005 - 2008 
14
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, The role of thyroid hormone action in the developing brain and the mechanism generating critical period of its action., ,  2002 - 2004 
15
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Analysis of knockout mouse of a brain-specific H^+ transporter ASPT., ,  2002 - 2004 
16
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Gene targeting approach to study functions on respiratory and circulatory regulation of novel H^+ Channel, ,  1999 - 2001