Takasaki University of Health and Welfare

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YOSHIDA Kazuki

Profile Research field Research achievement Educational achievement Management achievement Social contribution achievement

 

Published Papers
No.Title URL, Journal, Vol( No), Start Page- End Page, Publication date, DOI 
1
Enhancement of mast cells activation by ATP via P2X4 receptor , Journal of Pharmacological Sciences, 159( 1), 39- 43, Jan. 1, 2024, https://doi.org/10.1254/fpj.23083 
2
Amplification of poly(I:C)-induced interleukin-6 production in human bronchial epithelial cells by priming with interferon-γ , Scientific Reports, 13( 1),  , Nov. 29, 2023, https://doi.org/10.1038/s41598-023-48422-9 
3
Exploratory study of oxatomide derivatives with high P2X7 receptor inhibitory activity , Bioorganic & Medicinal Chemistry Letters, 77,  129035- 129035, Dec. 2022, https://doi.org/10.1016/j.bmcl.2022.129035 
4
P2X4 receptor stimulation enhances MrgprB2-mediated mast cell activation and pseudoallergic reactions in mice , Scientific Reports, 12( 1), 18613- , Nov. 3, 2022, https://doi.org/10.1038/s41598-022-21667-6 
5
Purinergic regulation of mast cell function: P2X4 receptor-mediated enhancement of allergic responses. , Journal of pharmacological sciences, 150( 2), 94- 99, Oct. 2022, https://doi.org/10.1016/j.jphs.2022.07.005 
6
Differential Effects of Gq Protein-Coupled Uridine Receptor Stimulation on IL-8 Production in 1321N1 Human Astrocytoma Cells , Biological and Pharmaceutical Bulletin, 45( 6), 691- 697, Jun. 1, 2022, https://doi.org/10.1248/bpb.b21-01020 
7
Synergistic Cytokine Production by ATP and PGE2 via P2X4 and EP3 Receptors in Mouse Bone-Marrow-Derived Mast Cells , Cells, 11( 4), 616- 616, Feb. 10, 2022, https://doi.org/10.3390/cells11040616 
8
Phenolsulfonphthalein as a surrogate substrate to assess altered function of the prostaglandin transporter SLCO2A1 , Drug Metabolism and Pharmacokinetics, ,  100452- 100452, Feb. 2022, https://doi.org/10.1016/j.dmpk.2022.100452 
9
Elucidation of Mast Cell Activation Mechanism Mediated by Purinergic Signaling , YAKUGAKU ZASSHI, 141( 9), 1057- 1061, Sep. 1, 2021, https://doi.org/10.1248/yakushi.21-00113 
10
Extracellular ATP Augments Antigen-Induced Murine Mast Cell Degranulation and Allergic Responses via P2X4 Receptor Activation , The Journal of Immunology, 204( 12), 3077- 3085, Jun. 15, 2020, https://doi.org/10.4049/jimmunol.1900954 
11
Co-Stimulation of Purinergic P2X4 and Prostanoid EP3 Receptors Triggers Synergistic Degranulation in Murine Mast Cells. , International journal of molecular sciences, 20( 20), 5157- 5157, Oct. 2019, https://doi.org/10.3390/ijms20205157 
12
Effects of dexamethasone on purinergic signaling in murine mast cells: Selective suppression of P2X7 receptor expression , BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 493( 4), 1587- 1593, Dec. 2017, https://doi.org/10.1016/j.bbrc.2017.10.020 
13
Identification of novel selective P2Y(6) receptor antagonists by high-throughput screening assay , LIFE SCIENCES, 180,  137- 142, Jul. 2017, https://doi.org/10.1016/j.lfs.2017.05.017 
14
Divergent regulatory roles of extracellular ATP in the degranulation response of mouse bone marrow-derived mast cells , INTERNATIONAL IMMUNOPHARMACOLOGY, 43,  99- 107, Feb. 2017, https://doi.org/10.1016/j.intimp.2016.12.014 
15
P2X7 receptor antagonist activity of the anti-allergic agent oxatomide , EUROPEAN JOURNAL OF PHARMACOLOGY, 767,  41- 51, Nov. 2015, https://doi.org/10.1016/j.ejphar.2015.10.002 

 

MISC
No.Title URL, Journal, Vol( No), Start Page- End Page, Publication date 
1
Analysis of ATP-induced enhancement of interleukin 6 production in human glioblastoma , 日本薬学会年会要旨集(Web), 142nd,   , 2022 
2
Evaluation of mesenteric artery function in LPS-induced sepsis model mice , 日本薬学会年会要旨集(Web), 142nd,   , 2022 
3
Analysis of synergistic cytokine production induced by co-stimulation of ATP and PGE2 in mast cells , 日本薬学会年会要旨集(Web), 142nd,   , 2022 
4
Synergistic effects of IFN-γ and poly(I:C) on cytokine production in human airway epithelial NCl-H292 cells , 日本薬学会年会要旨集(Web), 142nd,   , 2022 
5
P2X4 receptor signaling enhanced psuedallergyc response , 日本薬学会年会要旨集(Web), 142nd,   , 2022 
6
Effects of extracellular ATP on cytokine production in mouse bone marrow-derived mast cells , 日本薬学会年会要旨集(Web), 141st,   , 2021 
7
Effect of P2X4 receptor on degranulation of connective tissue-type mast cell , 日本薬学会年会要旨集(Web), 141st,   , 2021 
8
Inhibitory effects of oxatomide derivatives on human P2X7 receotor , 日本薬学会年会要旨集(CD-ROM), 140th,   , 2020 
9
Inhibitory effects of statins on P2Y1 receptor-mediated IL-8 release , 日本薬学会年会要旨集(CD-ROM), 140th,   , 2020 
10
Effect of IL-33 on purinergic receptor expression in bone marrow-derived mast cell , 日本薬学会年会要旨集(CD-ROM), 140th,   , 2020 

 

Conference Activities & Talks
No.Title, Conference, Publication date, Promoter, Venue 
1
P2X4 receptor signaling potentiate Mas-relate G protein-coupled receptor B2-induced mast cell degranulation, , Mar. 2022, ,  
2
P2X4 receptor signaling enhance pseudallergic responses in mice, , Mar. 2022, ,  
3
Effect of compound48/80 on antigen-dependent degranulation in BMMC, , Mar. 2020, ,  
4
Role of purinergic P2X4 receptors in antigen-induced mast cell degranulation and allergic responses, , Dec. 2019, ,  
5
Suppression of P2X7 receptor expression by dexamethasone in mast cells, 2nd World congress on Pharmacology & Toxicology, Sep. 2018, ,  
6
Synergistic effect of ATP and prostaglandin E2 on mast cell degranulation, 18th world congress of basic and clinical pharmacology, Jul. 2018, ,  
7
Identification and characterization of the antihistamine oxatomide as a P2X7 receptor antagonist, , Nov. 2016, ,  
8
抗アレルギー薬オキサトミドのP2X7 受容体阻害作用, 20th Japan Purine Club Meeting, Oct. 2016, ,  
9
抗ヒスタミン薬であるオキサトミドのP2X7受容体を介するATP誘発膜電流に及ぼす阻害作用, 日本薬学会第135年会, Mar. 2015, ,  
10
Pharmacological properties of Oxatomide as P2X7 receptor antagonist, , Mar. 2015, ,  
11
Role of P2X7 receptor-mediated signaling in human B cell like myeloma RPMI8226 cells, , Mar. 2014, ,  
12
Effects of oxatomide on ATP-mediated responses at P2X7 receptor in N18-TG2 cells, , Mar. 2013, ,  

 

Research Grants & Projects
No.Offer organization, System name, Title, Fund classification, Date 
1
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Establishment of therapeutic basis for allergic diseases targeting P2X4 receptor of mast cells, ,  Apr. 2019 - Mar. 2022