Takasaki University of Health and Welfare

Researchers Information System

Japanese English

TOP
Search by Faculty
or Department
Search by Keyword
Search by Research
Field
Detailed Search

Takasaki University of Health and Welfare top

YOSHIDA Kazuki

Profile Research field Research achievement Educational achievement Management achievement Social contribution achievement

 

Published Papers
No.Title URL, Journal, Vol( No), Start Page- End Page, Publication date, DOI 
1
Enhancement of mast cells activation by ATP via P2X4 receptor , Journal of Pharmacological Sciences, 159( 1), 39- 43, Jan. 1, 2024, https://doi.org/10.1254/fpj.23083 
2
Amplification of poly(I:C)-induced interleukin-6 production in human bronchial epithelial cells by priming with interferon-γ , Scientific Reports, 13( 1),  , Nov. 29, 2023, https://doi.org/10.1038/s41598-023-48422-9 
3
Exploratory study of oxatomide derivatives with high P2X7 receptor inhibitory activity , Bioorganic & Medicinal Chemistry Letters, 77,  129035- 129035, Dec. 2022, https://doi.org/10.1016/j.bmcl.2022.129035 
4
P2X4 receptor stimulation enhances MrgprB2-mediated mast cell activation and pseudoallergic reactions in mice , Scientific Reports, 12( 1), 18613- , Nov. 3, 2022, https://doi.org/10.1038/s41598-022-21667-6 
5
Purinergic regulation of mast cell function: P2X4 receptor-mediated enhancement of allergic responses. , Journal of pharmacological sciences, 150( 2), 94- 99, Oct. 2022, https://doi.org/10.1016/j.jphs.2022.07.005 
6
Differential Effects of Gq Protein-Coupled Uridine Receptor Stimulation on IL-8 Production in 1321N1 Human Astrocytoma Cells , Biological and Pharmaceutical Bulletin, 45( 6), 691- 697, Jun. 1, 2022, https://doi.org/10.1248/bpb.b21-01020 
7
Synergistic Cytokine Production by ATP and PGE2 via P2X4 and EP3 Receptors in Mouse Bone-Marrow-Derived Mast Cells , Cells, 11( 4), 616- 616, Feb. 10, 2022, https://doi.org/10.3390/cells11040616 
8
Phenolsulfonphthalein as a surrogate substrate to assess altered function of the prostaglandin transporter SLCO2A1 , Drug Metabolism and Pharmacokinetics, ,  100452- 100452, Feb. 2022, https://doi.org/10.1016/j.dmpk.2022.100452 
9
Elucidation of Mast Cell Activation Mechanism Mediated by Purinergic Signaling , YAKUGAKU ZASSHI, 141( 9), 1057- 1061, Sep. 1, 2021, https://doi.org/10.1248/yakushi.21-00113 
10
Extracellular ATP Augments Antigen-Induced Murine Mast Cell Degranulation and Allergic Responses via P2X4 Receptor Activation , The Journal of Immunology, 204( 12), 3077- 3085, Jun. 15, 2020, https://doi.org/10.4049/jimmunol.1900954 
11
Co-Stimulation of Purinergic P2X4 and Prostanoid EP3 Receptors Triggers Synergistic Degranulation in Murine Mast Cells. , International journal of molecular sciences, 20( 20), 5157- 5157, Oct. 2019, https://doi.org/10.3390/ijms20205157 
12
Effects of dexamethasone on purinergic signaling in murine mast cells: Selective suppression of P2X7 receptor expression , BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 493( 4), 1587- 1593, Dec. 2017, https://doi.org/10.1016/j.bbrc.2017.10.020 
13
Identification of novel selective P2Y(6) receptor antagonists by high-throughput screening assay , LIFE SCIENCES, 180,  137- 142, Jul. 2017, https://doi.org/10.1016/j.lfs.2017.05.017 
14
Divergent regulatory roles of extracellular ATP in the degranulation response of mouse bone marrow-derived mast cells , INTERNATIONAL IMMUNOPHARMACOLOGY, 43,  99- 107, Feb. 2017, https://doi.org/10.1016/j.intimp.2016.12.014 
15
P2X7 receptor antagonist activity of the anti-allergic agent oxatomide , EUROPEAN JOURNAL OF PHARMACOLOGY, 767,  41- 51, Nov. 2015, https://doi.org/10.1016/j.ejphar.2015.10.002 

 

MISC
No.Title URL, Journal, Vol( No), Start Page- End Page, Publication date 
1
Evaluation of mesenteric artery function in LPS-induced sepsis model mice , 日本薬学会年会要旨集(Web), 142nd,   , 2022 
2
P2X4 receptor signaling enhanced psuedallergyc response , 日本薬学会年会要旨集(Web), 142nd,   , 2022 
3
Analysis of ATP-induced enhancement of interleukin 6 production in human glioblastoma , 日本薬学会年会要旨集(Web), 142nd,   , 2022 
4
Analysis of synergistic cytokine production induced by co-stimulation of ATP and PGE2 in mast cells , 日本薬学会年会要旨集(Web), 142nd,   , 2022 
5
Synergistic effects of IFN-γ and poly(I:C) on cytokine production in human airway epithelial NCl-H292 cells , 日本薬学会年会要旨集(Web), 142nd,   , 2022 
6
Effects of extracellular ATP on cytokine production in mouse bone marrow-derived mast cells , 日本薬学会年会要旨集(Web), 141st,   , 2021 
7
Effect of P2X4 receptor on degranulation of connective tissue-type mast cell , 日本薬学会年会要旨集(Web), 141st,   , 2021 
8
Inhibitory effects of statins on P2Y1 receptor-mediated IL-8 release , 日本薬学会年会要旨集(CD-ROM), 140th,   , 2020 
9
Inhibitory effects of oxatomide derivatives on human P2X7 receotor , 日本薬学会年会要旨集(CD-ROM), 140th,   , 2020 
10
Effect of IL-33 on purinergic receptor expression in bone marrow-derived mast cell , 日本薬学会年会要旨集(CD-ROM), 140th,   , 2020 

 

Conference Activities & Talks
No.Title, Conference, Publication date, Promoter, Venue 
1
P2X4 receptor signaling potentiate Mas-relate G protein-coupled receptor B2-induced mast cell degranulation, , Mar. 2022, ,  
2
P2X4 receptor signaling enhance pseudallergic responses in mice, , Mar. 2022, ,  
3
Effect of compound48/80 on antigen-dependent degranulation in BMMC, , Mar. 2020, ,  
4
Role of purinergic P2X4 receptors in antigen-induced mast cell degranulation and allergic responses, , Dec. 2019, ,  
5
Suppression of P2X7 receptor expression by dexamethasone in mast cells, 2nd World congress on Pharmacology & Toxicology, Sep. 2018, ,  
6
Synergistic effect of ATP and prostaglandin E2 on mast cell degranulation, 18th world congress of basic and clinical pharmacology, Jul. 2018, ,  
7
Identification and characterization of the antihistamine oxatomide as a P2X7 receptor antagonist, , Nov. 2016, ,  
8
抗アレルギー薬オキサトミドのP2X7 受容体阻害作用, 20th Japan Purine Club Meeting, Oct. 2016, ,  
9
抗ヒスタミン薬であるオキサトミドのP2X7受容体を介するATP誘発膜電流に及ぼす阻害作用, 日本薬学会第135年会, Mar. 2015, ,  
10
Pharmacological properties of Oxatomide as P2X7 receptor antagonist, , Mar. 2015, ,  
11
Role of P2X7 receptor-mediated signaling in human B cell like myeloma RPMI8226 cells, , Mar. 2014, ,  
12
Effects of oxatomide on ATP-mediated responses at P2X7 receptor in N18-TG2 cells, , Mar. 2013, ,  

 

Research Grants & Projects
No.Offer organization, System name, Title, Fund classification, Date 
1
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Establishment of therapeutic basis for allergic diseases targeting P2X4 receptor of mast cells, ,  Apr. 2019 - Mar. 2022