Takasaki University of Health and Welfare

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FUKUCHI Mamoru

Profile Research field Research achievement Educational achievement Management achievement Social contribution achievement

 

Published Papers
No.Title URL, Journal, Vol( No), Start Page- End Page, Publication date, DOI 
1
Psychiatric Neural Networks and Precision Therapeutics by Machine Learning , Biomedicines, 9( 4), 403- 403, Apr. 8, 2021, https://doi.org/10.3390/biomedicines9040403 
2
Visualization of activity-regulated BDNF expression in the living mouse brain using non-invasive near-infrared bioluminescence imaging , Molecular Brain, 13( 1), 122- , Sep. 7, 2020, https://doi.org/10.1186/s13041-020-00665-7 
3
Differential localization and roles of splice variants of rat suppressor of cancer cell invasion (SCAI) in neuronal cells , Biochemical and Biophysical Research Communications, 529( 3), 615- 621, Aug. 2020, https://doi.org/10.1016/j.bbrc.2020.06.064 
4
Expression of SOLOIST/MRTFB i4, a novel neuronal isoform of the mouse serum response factor coactivator myocardin-related transcription factor-B, negatively regulates dendritic complexity in cortical neurons. , Journal of neurochemistry, ,   , Jul. 8, 2020, https://doi.org/10.1111/jnc.15122 
5
Neuron-enriched phosphatase and actin regulator 3 (Phactr3)/ nuclear scaffold-associated PP1-inhibiting protein (Scapinin) regulates dendritic morphology via its protein phosphatase 1-binding domain , Biochemical and Biophysical Research Communications, 528( 2), 322- 329, Jul. 2020, https://doi.org/10.1016/j.bbrc.2020.05.006 
6
Studies of Neuronal Gene Regulation Controlling the Molecular Mechanisms Underlying Neural Plasticity. , Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 137( 9), 1103- 1115, 2017, https://doi.org/10.1248/yakushi.17-00107 
7
Neuromodulatory effect of Gαs- or Gαq-coupled G-protein-coupled receptor on NMDA receptor selectively activates the NMDA receptor/Ca2+/calcineurin/cAMP response element-binding protein-regulated transcriptional coactivator 1 pathway to effectively induce brain-derived neurotrophic factor expression in neurons. , The Journal of neuroscience : the official journal of the Society for Neuroscience, 35( 14), 5606- 24, Apr. 8, 2015, https://doi.org/10.1523/JNEUROSCI.3650-14.2015 
8
GABA-driven excitatory neurotransmission: gene regulation by excitatory GABA and its possible role in the developing brain , Neurotransmitter, 2,  e480- , 2015,  
9
Functional analysis of platelet-derived growth factor receptor-β in neural stem/progenitor cells , Neuroscience, 238,  195- 208, May. 15, 2013, https://doi.org/10.1016/j.neuroscience.2013.02.021 
10
Identification, expression and characterization of rat isoforms of the serum response factor (SRF) coactivator MKL1. , FEBS open bio, 3,  387- 93, 2013, https://doi.org/10.1016/j.fob.2013.09.001 
11
Synthesis and biological evaluation of pyrethroid insecticide-derivatives as a chemical inducer for Bdnf mRNA expression in neurons. , Bioorganic & medicinal chemistry, 20( 8), 2564- 71, Apr. 15, 2012, https://doi.org/10.1016/j.bmc.2012.02.048 
12
Deltamethrin, a type II pyrethroid insecticide, has neurotrophic effects on neurons with continuous activation of the Bdnf promoter. , Neuropharmacology, 62( 2), 1091- 8, Feb. 2012, https://doi.org/10.1016/j.neuropharm.2011.10.023 
13
Activation of tyrosine hydroxylase (TH) gene transcription induced by brain-derived neurotrophic factor (BDNF) and its selective inhibition through Ca(2+) signals evoked via the N-methyl-D-aspartate (NMDA) receptor. , Brain research, 1366,  18- 26, Dec. 17, 2010, https://doi.org/10.1016/j.brainres.2010.10.034 
14
アクチン結合性転写活性化因子MKLはアクチビンに誘導される転写活性および樹状突起形態の変化に関与する(Actin-binding coactivator MKL is involved in activin-induced transcriptional activity and alteration of dendritic morphology in rat cortical neurons) , 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 83回・33回,  1P- 0762, Dec. 2010,  
15
Involvement of the 3'-untranslated region of the brain-derived neurotrophic factor gene in activity-dependent mRNA stabilization. , Journal of neurochemistry, 115( 5), 1222- 33, Dec. 2010, https://doi.org/10.1111/j.1471-4159.2010.07016.x 
16
Pituitary adenylate cyclase-activating polypeptide (PACAP) is an upstream regulator of prodynorphin mRNA expression in neurons. , Neuroscience letters, 484( 3), 174- 7, Nov. 5, 2010, https://doi.org/10.1016/j.neulet.2010.08.044 
17
Involvement of the serum response factor coactivator megakaryoblastic leukemia (MKL) in the activin-regulated dendritic complexity of rat cortical neurons. , The Journal of biological chemistry, 285( 43), 32734- 43, Oct. 22, 2010, https://doi.org/10.1074/jbc.M110.118745 
18
Differential epigenetic regulation of BDNF and NT-3 genes by trichostatin A and 5-aza-2'-deoxycytidine in Neuro-2a cells. , Biochemical and biophysical research communications, 394( 1), 173- 7, Mar. 26, 2010, https://doi.org/10.1016/j.bbrc.2010.02.139 
19
Persistent BDNF exon I-IX mRNA expression following the withdrawal of neuronal activity in neurons. , Biochemical and biophysical research communications, 390( 3), 648- 53, Dec. 18, 2009, https://doi.org/10.1016/j.bbrc.2009.10.021 
20
Valproic acid induces up- or down-regulation of gene expression responsible for the neuronal excitation and inhibition in rat cortical neurons through its epigenetic actions. , Neuroscience research, 65( 1), 35- 43, Sep. 2009, https://doi.org/10.1016/j.neures.2009.05.002 
21
Remote control of activity-dependent BDNF gene promoter-I transcription mediated by REST/NRSF. , Biochemical and biophysical research communications, 384( 4), 506- 11, Jul. 10, 2009, https://doi.org/10.1016/j.bbrc.2009.05.007 
22
Extracellular adenosine 5'-triphosphate elicits the expression of brain-derived neurotrophic factor exon IV mRNA in rat astrocytes. , Glia, 56( 13), 1369- 79, Oct. 2008, https://doi.org/10.1002/glia.20704 
23
Identification of genetic networks involved in the cell growth arrest and differentiation of a rat astrocyte cell line RCG-12. , Journal of cellular biochemistry, 102( 6), 1472- 85, Dec. 15, 2007, https://doi.org/10.1002/jcb.21369 
24
Robust stimulation of TrkB induces delayed increases in BDNF and Arc mRNA expressions in cultured rat cortical neurons via distinct mechanisms. , Journal of neurochemistry, 103( 2), 626- 36, Oct. 2007, https://doi.org/10.1111/j.1471-4159.2007.04851.x 
25
Role of activity-dependent gene expression of BDNF gene in synaptic plasticity , SEIKAGAKU, 78( 10), 998- 1007, Oct. 2006,  
26
Interference with activity-dependent transcriptional activation of BDNF gene depending upon the expanded polyglutamines in neurons. , Biochemical and biophysical research communications, 333( 4), 1241- 8, Aug. 12, 2005, https://doi.org/10.1016/j.bbrc.2005.06.032 
27
Transcriptional regulation of neuronal genes and its effect on neural functions: cumulative mRNA expression of PACAP and BDNF genes controlled by calcium and cAMP signals in neurons. , Journal of pharmacological sciences, 98( 3), 212- 8, Jul. 2005, https://doi.org/10.1254/jphs.FMJ05001X4 
28
Activity-dependent transcriptional activation and mRNA stabilization for cumulative expression of pituitary adenylate cyclase-activating polypeptide mRNA controlled by calcium and cAMP signals in neurons. , The Journal of biological chemistry, 279( 46), 47856- 65, Nov. 12, 2004, https://doi.org/10.1074/jbc.M409090200 
29
Calcium signal-mediated expression of the vasoactive intestinal polypeptide gene and its small contribution to activity-dependent survival of mouse cerebellar granule cells. , Journal of neuroscience research, 77( 1), 26- 34, Jul. 1, 2004, https://doi.org/10.1002/jnr.20132 
30
Activity-dependent increase in beta-amyloid precursor protein mRNA expression in neurons. , Neuroreport, 15( 8), 1329- 33, Jun. 7, 2004,  
31
Inactivation of aconitase during the apoptosis of mouse cerebellar granule neurons induced by a deprivation of membrane depolarization. , Journal of neuroscience research, 71( 4), 504- 15, Feb. 15, 2003, https://doi.org/10.1002/jnr.10505 

 

MISC
No.Title URL, Journal, Vol( No), Start Page- End Page, Publication date 
1
自由行動下の動物の深部組織から非侵襲的に発光を検出する技術 , ファルマシア, 55( 1), 69- , Jan. 2019 
2
生物発光を利用したBDNF遺伝子発現変化の計測 , 日本生化学会大会(Web), 2017年度,  [2P- 1200], Dec. 2017 
3
In silico and pharmacological screening identify novel PAC1 receptor antagonists , JOURNAL OF PHARMACOLOGICAL SCIENCES, 130( 3), S236- , Mar. 2016 
4
In vitroとin vivoにおける、Rho/MAL/SRF経路を介したV-1遺伝子による黒質線条体のドーパミン系の機能の調節(In vitro and in vivo regulation of the nigrostriatal dopaminergic function by V-1 gene via the Rho/MAL/SRF pathway) , パーキンソン病・運動障害疾患コングレスプログラム・抄録集, 9回,  66- 66, Oct. 2015 
5
GPCR活性化によるNMDAレセプター/カルシニューリン/CRTC1/CREB経路を介したBDNF遺伝子発現誘導 , 日本薬学会年会要旨集(CD-ROM), 135年会( 3), 78- 78, Mar. 2015 
6
生物発光を利用した神経ペプチドPACAPによる脳由来神経栄養因子BDNF遺伝子発現制御機構の解明 , 次世代を担う若手ファーマ・バイオフォーラム講演要旨集, 13th,  29- , Sep. 2014 
7
GPCR活性化によるNMDAR/カルシニューリン/CRTC1経路の選択的活性化を介した遺伝子発現誘導 , 日本生物学的精神医学会誌, ,  241- , 2014 
8
Novel actin-based regulatory mechanism of nigrostriatal dopaminergic function by V-1 in vitro and in vivo , JOURNAL OF PHARMACOLOGICAL SCIENCES, 124,  79P- 79P, 2014 
9
生物発光イメージングによる脳由来神経栄養因子BDNF発現変化のモニタリング , 日本薬学会年会要旨集(CD-ROM), 133年会( 3), 102- 102, Mar. 2013 
10
生物発光を利用した培養大脳皮質ニューロンにおける脳由来神経栄養因子BDNF遺伝子発現変化の可視化 , 日本分子生物学会年会プログラム・要旨集(Web), 36th,  2P-0702 (WEB ONLY)- , 2013 
11
生物発光を利用したマウス脳内における脳由来神経栄養因子BDNF遺伝子発現変化の解析 , 日本分子生物学会年会プログラム・要旨集(Web), 35th,  2P-0777 (WEB ONLY)- , 2012 
12
GPCR signaling induces activity-dependent gene expression through activation of NMDA receptor , NEUROSCIENCE RESEARCH, 71,  E114- E115, 2011 
13
Deltamethrin, a type II pyrethroid insecticide, induces marked Bdnf mRNA expression and morphological changes by maintaining the elevated concentration of calcium in cultured cortical neurons , NEUROSCIENCE RESEARCH, 71,  E121- E121, 2011 
14
Differential usage of the Arc/Arg3.1 gene promoter by the BDNF- and the neuronal activity-induced transcription activation in neurons , NEUROSCIENCE RESEARCH, 71,  E114- E114, 2011 
15
Phosphorylation of the SRF coactivator MKL1 induced by brain-derived neurotrophic factor (BDNF) in rat cortical neurons , NEUROSCIENCE RESEARCH, 71,  E335- E335, 2011 
16
PACAP induces BDNF gene expression through calcineurin-TORC1-CREB pathway evoked via activation of NMDA receptor , NEUROSCIENCE RESEARCH, 71,  E115- E115, 2011 
17
Developmental expression of the MKL/SRF corepressor SCAI in the brain , NEUROSCIENCE RESEARCH, 71,  E233- E233, 2011 
18
Actin-binding coactivator MKL is involved in a novel signaling pathway for activin-regulated dendritic complexity of rat cortical neurons , NEUROSCIENCE RESEARCH, 71,  E333- E333, 2011 
19
GABA induces activity-dependent gene expression in immature cortical cell culture , NEUROSCIENCE RESEARCH, 71,  E114- E114, 2011 
20
Pituitary adenylate cyclase-activating polypeptide (PACAP) induces activity-dependent gene expression through the potentiation of N-methyl-D-aspartate receptor (NMDA-R) in neurons , JOURNAL OF MOLECULAR NEUROSCIENCE, 42( 3), 318- 318, Nov. 2010 
21
Pituitary adenylate cyclase-activating polypeptide (PACAP) induces activity-dependent gene expression in neurons , JOURNAL OF MOLECULAR NEUROSCIENCE, 42( 3), 298- 299, Nov. 2010 
22
Neuro-2aにおけるBDNFとNT-3のエピジェネティックな遺伝子発現制御機構の解析(Differential epigenetic regulation of BDNF and NT-3 genes in Neuro-2a cells) , 神経化学, 49( 2-3), 702- 702, Aug. 2010 
23
G protein-coupled receptor (GPCR) signaling induces activity-dependent gene expression through the modulation of N-methyl-D-aspartate receptor (NMDA-R) in neurons , NEUROSCIENCE RESEARCH, 68,  E352- E352, 2010 
24
Differential epigenetic regulation of BDNF and NT-3 genes in Neuro-2a cells , NEUROSCIENCE RESEARCH, 68,  E352- E352, 2010 
25
Involvement of 3 '-untranslated region of brain-derived neurotrophic factor gene in activity-dependent mRNA stabilization , NEUROSCIENCE RESEARCH, 68,  E354- E354, 2010 
26
The brain-derived neurotrophic factor (BDNF) mRNA expression induced by type II-pyrethroid insecticides , NEUROSCIENCE RESEARCH, 65,  S70- S70, 2009 
27
Activation of Arc gene transcription regulated by BDNF in neurons , NEUROSCIENCE RESEARCH, 65,  S151- S151, 2009 
28
Valproic acid regulates the expression of excitatory or inhibitory neuron-related gene through histone acetylation , NEUROSCIENCE RESEARCH, 61,  S83- S83, 2008 
29
Involvement of 3 '-untranslated region (3 '-UTR) in the activity-dependent stabilization of brain-derived neurotrophic factor (BDNF) mRNA in neurons , NEUROSCIENCE RESEARCH, 61,  S153- S153, 2008 
30
Activity-dependent stabilization of BDNF mRNA regulated by calcium signals in neurons , NEUROSCIENCE RESEARCH, 55,  S116- S116, 2006 
31
Profiling of gene expression induced by BDNF or PACAP in the rat cultured neurons , NEUROSCIENCE RESEARCH, 55,  S116- S116, 2006 

 

Conference Activities & Talks
No.Title, Conference, Publication date, Promoter, Venue 
1
非侵襲的生体イメージングを用いたマウス脳内における活動依存的なBDNF遺伝子発現誘導の可視化, 第63回日本神経化学会大会, Sep. 10, 2020, ,  
2
Visualizing activity-dependent BDNF expression in living mouse brain, The 49th annual meeting of the Society for Neuroscience, Oct. 2019, ,  
3
Visualizing activity-regulated BDNF gene expression in living mouse brain using near-infrared bioluminescence, Neuro2019, Jul. 2019, ,  
4
BDNF-Lucマウスを用いた近赤外発光が得られる新規ルシフェラーゼ基質の比較検討, 日本薬学会第139年会, Mar. 2019, ,  
5
Visualization of changes in BDNF gene expression in vivo and construction of drug screening using luciferase-based bioluminescence, The Joint Congress of the 40th Annual Meeting of Japanese Society of Biological Psychiatry and the 61st Annual Meeting of the Japanese Society for Neurochemistry, Sep. 8, 2018, ,  
6
生物発光を利用したBDNF遺伝子発現変化の計測, 2017年度生命科学系学会合同年次大会(ConBio2017), Dec. 2017, ,  
7
Visualizing changes in brain-derived neurotrophic factor (BDNF) expression using bioluminescence imaging in living mice, , Sep. 2017, ,  
8
神経可塑性の分子基盤を担う遺伝子発現制御系の解明, 日本薬学会北陸支部第128回例会, Nov. 27, 2016, ,  
9
Monitoring and visualizing changes in the expression of BDNF gene using bioluminescence imaging, The 46th annual meeting of the Society for Neuroscience, Nov. 2016, ,  
10
神経細胞におけるGPCR活性化により作動する遺伝子発現制御のメカニズム, , May. 2016, ,  
11
Regulation of BDNF gene expression and its possible role in neural functions and diseases, , Sep. 2015, ,  
12
G タンパク質共役型受容体活性化による遺伝子発現制御機構, 日本生化学会北陸支部第33 回大会, May. 2015, ,  
13
GPCR活性化によるNMDA レセプター/カルシニューリン/CRTC1/CREB 経路を介したBDNF 遺伝子発現誘導, 日本薬学会第135 年会, Mar. 2015, ,  
14
脳・神経系における情報入力に依存した最初期遺伝子群の発現制御, 第1回北陸エピジェネティクス研究会, Nov. 2014, ,  
15
発光イメージングを用いた神経ペプチドPACAP による脳由来神経栄養因子BDNF 遺伝子発現誘導機構の解析, , May. 2014, ,  
16
G タンパク質共役型受容体(GPCR)活性化によるNMDA 型グルタミン酸受容体(NMDA-R)を介した遺伝子発現誘導機構に関する研究, , May. 2013, ,  
17
PACAPはNMDAレセプター活性化によるカルシニューリン-TORC1-CREB経路を介してBDNF遺伝子発現を誘導する, 第34回日本神経科学大会, Sep. 2011, ,  
18
Involvement of the promoter proximal region in brain-derived neurotrophic factor (BDNF)-induced Arc/Arg3.1 gene transcription, The 6th International Conference of Neurons and Brain Diseases, Aug. 2011, ,  

 

Research Grants & Projects
No.Offer organization, System name, Title, Fund classification, Date 
1
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Challenging Research (Exploratory), Involvement of BDNF in the pathogenesis of obesity; BDNF signaling hypothesis in adipose tissue, competitive_research_funding,  Jun. 2019 - Mar. 2022