Takasaki University of Health and Welfare

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NAKAMICHI Noritaka

Profile Research field Research achievement Educational achievement Management achievement Social contribution achievement

 

Published Papers
No.Title URL, Journal, Vol( No), Start Page- End Page, Publication date, DOI 
1
Oral Administration of the Food-Derived Hydrophilic Antioxidant Ergothioneine Enhances Object Recognition Memory in Mice. , Current molecular pharmacology, 14( 2), 220- 233, 2021, https://doi.org/10.2174/1874467213666200212102710 
2
Homostachydrine is a Xenobiotic Substrate of OCTN1/SLC22A4 and Potentially Sensitizes Pentylenetetrazole-Induced Seizures in Mice , Neurochemical Research, 45( 11), 2664- 2678, Nov. 2020, https://doi.org/10.1007/s11064-020-03118-8 
3
High-Speed SICM for the Visualization of Nanoscale Dynamic Structural Changes in Hippocampal Neurons. , Analytical chemistry, 92( 2), 2159- 2167, Jan. 21, 2020, https://doi.org/10.1021/acs.analchem.9b04775 
4
Metabolome Analysis Reveals Dermal Histamine Accumulation in Murine Dermatitis Provoked by Genetic Deletion of P-Glycoprotein and Breast Cancer Resistance Protein , Pharm. Res., 36( 11), 158- -, Nov. 2019, https://doi.org/10.1007/s11095-019-2695-3 
5
Influx and Efflux Transporters Contribute to the Increased Dermal Exposure to Active Metabolite of Regorafenib After Repeated Oral Administration in Mice. , Journal of pharmaceutical sciences, 108( 6), 2173- 2179, Jun. 2019, https://doi.org/10.1016/j.xphs.2019.01.018 
6
Bile Duct Obstruction Leads to Increased Intestinal Expression of Breast Cancer Resistance Protein With Reduced Gastrointestinal Absorption of Imatinib. , Journal of pharmaceutical sciences, 108( 9), 3130- 3137, May. 2019, https://doi.org/10.1016/j.xphs.2019.05.017 
7
Hydrolyzed Salmon Milt Extract Enhances Object Recognition and Location Memory Through an Increase in Hippocampal Cytidine Nucleoside Levels in Normal Mice , Journal of Medicinal Food, 22( 4), 408- 415, Apr. 2019, https://doi.org/10.1089/jmf.2018.4285 
8
Ergothioneine-induced neuronal differentiation is mediated through activation of S6K1 and neurotrophin 4/5-TrkB signaling in murine neural stem cells. , Cellular signalling, 53,  269- 280, Jan. 2019, https://doi.org/10.1016/j.cellsig.2018.10.012 
9
Maturational Characterization of Mouse Cortical Neurons Three-Dimensionally Cultured in Functional Polymer FP001-Containing Medium. , Biological & pharmaceutical bulletin, 42( 9), 1545- 1553, 2019, https://doi.org/10.1248/bpb.b19-00307 
10
[Possible Treatment of Neuropsychiatric Disorders by Promotion of Neuronal Differentiation through Organic Cation Transporters]. , Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 139( 6), 847- 852, 2019, https://doi.org/10.1248/yakushi.18-00173-1 
11
[Elucidation of the Mechanisms Underlying Regulation of Somatic Stem Cell Function: Possible Application to the Treatment of Neuropsychiatric, Metabolic Bone, and Lifestyle Diseases]. , Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 139( 6), 845- 846, 2019, https://doi.org/10.1248/yakushi.18-00173-F 
12
Organic cation transporter 1 is responsible for hepatocellular uptake of the tyrosine kinase inhibitor pazopanib , Drug Metabolism and Disposition, 46( 1), 33- 40, Jan. 1, 2018, https://doi.org/10.1124/dmd.117.076554 
13
Carnitine/Organic Cation Transporter OCTN1 Negatively Regulates Activation in Murine Cultured Microglial Cells , Neurochemical Research, 43( 1), 107- 119, Jan. 1, 2018, https://doi.org/10.1007/s11064-017-2350-5 
14
Combination Metabolomics Approach for Identifying Endogenous Substrates of Carnitine/Organic Cation Transporter OCTN1 , Pharmaceutical Research, 35( 11), 224- 224, 2018, https://doi.org/10.1007/s11095-018-2507-1 
15
Usefulness of kidney slices for functional analysis of apical reabsorptive transporters , SCIENTIFIC REPORTS, 7( 1), 12814- , Oct. 2017, https://doi.org/10.1038/s41598-017-12828-z 
16
Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites , JOURNAL OF PHARMACEUTICAL SCIENCES, 106( 9), 2632- 2641, Sep. 2017, https://doi.org/10.1016/j.xphs.2017.04.064 
17
Physiological Roles of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in Neural Cells , BIOLOGICAL & PHARMACEUTICAL BULLETIN, 40( 8), 1146- 1152, Aug. 2017, https://doi.org/10.1248/bpb.b17-00099 
18
Utilization of Liver Microsomes to Estimate Hepatic Intrinsic Clearance of Monoamine Oxidase Substrate Drugs in Humans , PHARMACEUTICAL RESEARCH, 34( 6), 1233- 1243, Jun. 2017, https://doi.org/10.1007/s11095-017-2140-4 
19
P-Glycoprotein in skin contributes to transdermal absorption of topical corticosteroids , INTERNATIONAL JOURNAL OF PHARMACEUTICS, 521( 1-2), 365- 373, Apr. 2017, https://doi.org/10.1016/j.ijpharm.2017.02.064 
20
Screening to Identify Multidrug Resistance-Associated Protein Inhibitors with Neuroblastoma-Selective Cytotoxicity , BIOLOGICAL & PHARMACEUTICAL BULLETIN, 39( 10), 1638- 1645, Oct. 2016, https://doi.org/10.1248/bpb.b16-00319 
21
L503F variant of carnitine/organic cation transporter 1 efficiently transports metformin and other biguanides , JOURNAL OF PHARMACY AND PHARMACOLOGY, 68( 9), 1160- 1169, Sep. 2016, https://doi.org/10.1111/jphp.12574 
22
Characterization of Long-Lasting Oatp Inhibition by Typical Inhibitor Cyclosporine A and In Vitro-In Vivo Discrepancy in Its Drug Interaction Potential in Rats , JOURNAL OF PHARMACEUTICAL SCIENCES, 105( 7), 2231- 2239, Jul. 2016, https://doi.org/10.1016/j.xphs.2016.04.025 
23
Critical evaluation and methodological positioning of the transdermal microdialysis technique. A review , JOURNAL OF CONTROLLED RELEASE, 233,  147- 161, Jul. 2016, https://doi.org/10.1016/j.jconrel.2016.05.035 
24
Food-derived hydrophilic antioxidant ergothioneine is distributed to the brain and exerts antidepressant effect in mice , BRAIN AND BEHAVIOR, 6( 6), e00477- , Jun. 2016, https://doi.org/10.1002/brb3.477 
25
A mutation in SLC22A4 encoding an organic cation transporter expressed in the cochlea strial endothelium causes human recessive non-syndromic hearing loss DFNB60 , HUMAN GENETICS, 135( 5), 513- 524, May. 2016, https://doi.org/10.1007/s00439-016-1657-7 
26
Localization of Xenobiotic Transporter OCTN1/SLC22A4 in Hepatic Stellate Cells and Its Protective Role in Liver Fibrosis , JOURNAL OF PHARMACEUTICAL SCIENCES, 105( 5), 1779- 1789, May. 2016, https://doi.org/10.1016/j.xphs.2016.02.023 
27
Possible activation by the green tea amino acid theanine of mammalian target of rapamycin signaling in undifferentiated neural progenitor cells in vitro , Biochemistry and Biophysics Reports, 5,  89- 95, Mar. 1, 2016, https://doi.org/10.1016/j.bbrep.2015.09.021 
28
Upregulation of Slc38a1 Gene Along with Promotion of Neurosphere Growth and Subsequent Neuronal Specification in Undifferentiated Neural Progenitor Cells Exposed to Theanine , NEUROCHEMICAL RESEARCH, 41( 1-2), 5- 15, Feb. 2016, https://doi.org/10.1007/s11064-015-1591-4 
29
Organic cation transporter Octn1-mediated uptake of food-derived antioxidant ergothioneine into infiltrating macrophages during intestinal inflammation in mice , DRUG METABOLISM AND PHARMACOKINETICS, 30( 3), 231- 239, Jun. 2015, https://doi.org/10.1016/j.dmpk.2015.02.003 
30
Gene Ablation of Carnitine/Organic Cation Transporter 1 Reduces Gastrointestinal Absorption of 5-Aminosalicylate in Mice , BIOLOGICAL & PHARMACEUTICAL BULLETIN, 38( 5), 774- 780, May. 2015, https://doi.org/10.1248/bpb.b15-00109 
31
Daily oral intake of theanine prevents the decline of 5-bromo-2 '-deoxyuridine incorporation in hippocampal dentate gyrus with concomitant alleviation of behavioral abnormalities in adult mice with severe traumatic stress , JOURNAL OF PHARMACOLOGICAL SCIENCES, 127( 3), 292- 297, Mar. 2015, https://doi.org/10.1016/j.jphs.2014.12.018 
32
Interaction of Novel Platelet-Increasing Agent Eltrombopag with Rosuvastatin via Breast Cancer Resistance Protein in Humans , DRUG METABOLISM AND DISPOSITION, 42( 4), 726- 734, Apr. 2014, https://doi.org/10.1124/dmd.113.054767 
33
Organic Cation Transporter-Mediated Ergothioneine Uptake in Mouse Neural Progenitor Cells Suppresses Proliferation and Promotes Differentiation into Neurons , PLOS ONE, 9( 2), e89434- , Feb. 2014, https://doi.org/10.1371/journal.pone.0089434 
34
Direct Inhibition and Down-regulation by Uremic Plasma Components of Hepatic Uptake Transporter for SN-38, an Active Metabolite of Irinotecan, in Humans , PHARMACEUTICAL RESEARCH, 31( 1), 204- 215, Jan. 2014, https://doi.org/10.1007/s11095-013-1153-x 
35
Involvement of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in Gastrointestinal Absorption of Metformin , JOURNAL OF PHARMACEUTICAL SCIENCES, 102( 9), 3407- 3417, Sep. 2013, https://doi.org/10.1002/jps.23595 
36
Myosin VI Reduces Proliferation, but Not Differentiation, in Pluripotent P19 Cells , PLoS ONE, 8( 5), e63947- , May. 17, 2013, https://doi.org/10.1371/journal.pone.0063947 
37
Role of organic cation/carnitine transporter 1 in uptake of phenformin and inhibitory effect on complex i respiration in mitochondria , Toxicological Sciences, 132( 1), 32- 42, Mar. 2013, https://doi.org/10.1093/toxsci/kfs330 
38
ATP binding cassette transporters in two distinct compartments of the skin contribute to transdermal absorption of a typical substrate , Journal of Controlled Release, 165( 1), 54- 61, Jan. 10, 2013, https://doi.org/10.1016/j.jconrel.2012.10.011 
39
Pharmacokinetic modeling of hepatocyte growth factor in experimental animals and humans , Journal of Pharmaceutical Sciences, 102( 1), 237- 249, 2013, https://doi.org/10.1002/jps.23337 
40
Functional expression of carnitine/organic cation transporter OCTN1 in mouse brain neurons: Possible involvement in neuronal differentiation , NEUROCHEMISTRY INTERNATIONAL, 61( 7), 1121- 1132, Dec. 2012, https://doi.org/10.1016/j.neuint.2012.08.004 
41
Possible neuroprotective property of nicotinic acetylcholine receptors in association with predominant upregulation of glial cell line-derived neurotrophic factor in astrocytes , JOURNAL OF NEUROSCIENCE RESEARCH, 90( 11), 2074- 2085, Nov. 2012, https://doi.org/10.1002/jnr.23101 
42
Promoted Neuronal Differentiation after Activation of Alpha4/Beta2 Nicotinic Acetylcholine Receptors in Undifferentiated Neural Progenitors , PLOS ONE, 7( 10), e46177- , Oct. 2012, https://doi.org/10.1371/journal.pone.0046177 
43
Promotion of Both Proliferation and Neuronal Differentiation in Pluripotent P19 Cells with Stable Overexpression of the Glutamine Transporter slc38a1 , PLOS ONE, 7( 10), e48270- , Oct. 2012, https://doi.org/10.1371/journal.pone.0048270 
44
Delayed Mitochondrial Membrane Potential Disruption by ATP in Cultured Rat Hippocampal Neurons Exposed to N-Methyl-D-Aspartate , JOURNAL OF PHARMACOLOGICAL SCIENCES, 119( 1), 20- 29, May. 2012, https://doi.org/10.1254/jphs.12034FP 
45
Transferrin receptor-1 suppresses neurite outgrowth in neuroblastoma Neuro2A cells , NEUROCHEMISTRY INTERNATIONAL, 60( 5), 448- 457, Apr. 2012, https://doi.org/10.1016/j.neuint.2011.08.018 
46
PDZK1 Regulates Breast Cancer Resistance Protein in Small Intestine , DRUG METABOLISM AND DISPOSITION, 39( 11), 2148- 2154, Nov. 2011, https://doi.org/10.1124/dmd.111.040295 
47
Functional Glutamate Signaling in Neural Progenitor Cells , YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 131( 9), 1311- 1316, Sep. 2011, https://doi.org/10.1248/yakushi.131.1311 
48
A possible pivotal role of mitochondrial free calcium in neurotoxicity mediated by N-methyl-D-aspartate receptors in cultured rat hippocampal neurons , NEUROCHEMISTRY INTERNATIONAL, 59( 1), 10- 20, Aug. 2011, https://doi.org/10.1016/j.neuint.2011.03.018 
49
Pharmacokinetics and Hepatic Uptake of Eltrombopag, a Novel Platelet-Increasing Agent , DRUG METABOLISM AND DISPOSITION, 39( 6), 1088- 1096, Jun. 2011, https://doi.org/10.1124/dmd.110.037960 
50
Exacerbated vulnerability to oxidative stress in astrocytic C6 glioma cells with stable overexpression of the glutamine transporter slc38a1 , NEUROCHEMISTRY INTERNATIONAL, 58( 4), 504- 511, Mar. 2011, https://doi.org/10.1016/j.neuint.2011.01.007 
51
Gradual Downregulation of Protein Expression of the Partner GABA(B)R2 Subunit During Postnatal Brain Development in Mice Defective of GABA(B)R1 Subunit , JOURNAL OF PHARMACOLOGICAL SCIENCES, 115( 1), 45- 55, Jan. 2011, https://doi.org/10.1254/jphs.10254FP 
52
Requirement of both NR3A and NR3B subunits for dominant negative properties on Ca2+ mobilization mediated by acquired N-methyl-D-aspartate receptor channels into mitochondria , NEUROCHEMISTRY INTERNATIONAL, 57( 7), 730- 737, Dec. 2010, https://doi.org/10.1016/j.neuint.2010.08.009 
53
Functional Expression of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in Mouse Small Intestine and Liver , DRUG METABOLISM AND DISPOSITION, 38( 10), 1665- 1672, Oct. 2010, https://doi.org/10.1124/dmd.110.032763 
54
Preferential Inhibition by Antidiarrheic 2-Methoxy-4-Methylphenol of Ca2+ Influx Across Acquired N-Methyl-D-Aspartate Receptor Channels Composed of NR1/NR2B Subunit Assembly , JOURNAL OF NEUROSCIENCE RESEARCH, 88( 11), 2483- 2493, Aug. 2010, https://doi.org/10.1002/jnr.22399 
55
Induced Tolerance to Glutamate Neurotoxicity Through Down-Regulation of NR2 Subunits of N-Methyl-D-Aspartate Receptors in Cultured Rat Striatal Neurons , JOURNAL OF NEUROSCIENCE RESEARCH, 88( 10), 2177- 2187, Aug. 2010, https://doi.org/10.1002/jnr.22388 
56
Inhibition by 2-Methoxy-4-ethylphenol of Ca2+ Influx Through Acquired and Native N-Methyl-D-aspartate-Receptor Channels , JOURNAL OF PHARMACOLOGICAL SCIENCES, 112( 3), 273- 281, Mar. 2010, https://doi.org/10.1254/jphs.09294FP 
57
PDZK1 Regulates Organic Anion Transporting Polypeptide Oatp1a in Mouse Small Intestine , DRUG METABOLISM AND PHARMACOKINETICS, 25( 6), 588- 598, 2010, https://doi.org/10.2133/dmpk.DMPK-10-RG-074 
58
RAGE-mediated signaling contributes to intraneuronal transport of amyloid-beta and neuronal dysfunction , PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 106( 47), 20021- 20026, Nov. 2009, https://doi.org/10.1073/pnas.0905686106 
59
A protein-protein interaction of stress-responsive myosin VI endowed to inhibit neural progenitor self-replication with RNA binding protein, TLS, in murine hippocampus , JOURNAL OF NEUROCHEMISTRY, 110( 5), 1457- 1468, Sep. 2009, https://doi.org/10.1111/j.1471-4159.2009.06225.x 
60
Possible Promotion of Neuronal Differentiation in Fetal Rat Brain Neural Progenitor Cells After Sustained Exposure to Static Magnetism , JOURNAL OF NEUROSCIENCE RESEARCH, 87( 11), 2406- 2417, Aug. 2009, https://doi.org/10.1002/jnr.22087 
61
Possible Protection by Notoginsenoside R1 against Glutamate Neurotoxicity Mediated by N-methyl-D-aspartate Receptors Composed of an NR1/NR2B Subunit Assembly , JOURNAL OF NEUROSCIENCE RESEARCH, 87( 9), 2145- 2156, Jul. 2009, https://doi.org/10.1002/jnr.22021 
62
Neurogenesis Mediated by gamma-Aminobutyric Acid and Glutamate Signaling , JOURNAL OF PHARMACOLOGICAL SCIENCES, 110( 2), 133- 149, Jun. 2009, https://doi.org/10.1254/jphs.08R03CR 
63
Up-regulation of ciliary neurotrophic factor receptor expression by GABA(A) receptors in undifferentiated neural progenitors of fetal mouse brain , JOURNAL OF NEUROSCIENCE RESEARCH, 86( 12), 2615- 2623, Sep. 2008, https://doi.org/10.1002/jnr.21708 
64
Modulation of cellular proliferation and differentiation through GABA(B) receptors expressed by undifferentiated neural progenitor cells isolated from fetal mouse brain , JOURNAL OF CELLULAR PHYSIOLOGY, 216( 2), 507- 519, Aug. 2008, https://doi.org/10.1002/jcp.21422 
65
GABAシグナルによるマウス神経系前駆細胞の増殖と分化の調節(Modulation of proliferation and differentiation by GABAergic signaling in murine neural progenitor cells) , 神経化学, 47( 2-3), 225- 225, Aug. 2008,  
66
Promotion of neuronal differentiation through activation of N-methyl-D-aspartate receptors transiently expressed by undifferentiated neural progenitor cells in fetal rat neocortex , JOURNAL OF NEUROSCIENCE RESEARCH, 86( 11), 2392- 2402, Aug. 2008, https://doi.org/10.1002/jnr.21696 
67
Insensitivity to glutamate neurotoxicity mediated by NMDA receptors in association with delayed mitochondrial membrane potential disruption in cultured rat cortical neurons , JOURNAL OF NEUROCHEMISTRY, 105( 5), 1886- 1900, Jun. 2008, https://doi.org/10.1111/j.1471-4159.2008.05270.x 
68
Transient suppression of progenitor cell proliferation through NMDA receptors in hippocampal dentate gyrus of mice with traumatic stress experience , JOURNAL OF NEUROCHEMISTRY, 105( 5), 1642- 1655, Jun. 2008, https://doi.org/10.1111/j.1471-4159.2008.05253.x 
69
Group III metabotropic glutamate receptor activation suppresses self-replication of undifferentiated neocortical progenitor cells , JOURNAL OF NEUROCHEMISTRY, 105( 5), 1996- 2012, Jun. 2008, https://doi.org/10.1111/j.1471-4159.2008.05289.x 
70
Upregulation of Myo6 expression after traumatic stress in mouse hippocampus , NEUROSCIENCE LETTERS, 433( 3), 183- 187, Mar. 2008, https://doi.org/10.1016/j.neulet.2007.12.062 
71
Protective effect of notoginsenoside R1 in Panax notoginseng on glutamate-induced neurotoxicity , YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 128,  184- 187, 2008,  
72
Activator protein-1 responsive to the group II metabotropic glutamate receptor subtype in association with intracellular calcium in cultured rat cortical neurons , NEUROCHEMISTRY INTERNATIONAL, 51( 8), 467- 475, Dec. 2007, https://doi.org/10.1016/j.neuint.2007.04.025 
73
Upregulation of the glutamine transporter through transactivation mediated by cAMP/protein kinase a signals toward exacerbation of vulnerability to oxidative stress in rat neocortical astrocytes , JOURNAL OF CELLULAR PHYSIOLOGY, 212( 2), 375- 385, Aug. 2007, https://doi.org/10.1002/jcp.21031 
74
Cytoprotective properties of phenolic antidiarrheic ingredients in cultured astrocytes and neurons of rat brains , EUROPEAN JOURNAL OF PHARMACOLOGY, 567( 1-2), 59- 66, Jul. 2007, https://doi.org/10.1016/j.ejphar.2007.03.034 
75
Activation of GABA(A) receptors facilitates astroglial differentiation induced by ciliary neurotrophic factor in neural progenitors isolated from fetal rat brain , JOURNAL OF NEUROCHEMISTRY, 100( 6), 1667- 1679, Mar. 2007, https://doi.org/10.1111/j.1471-4159.2006.04322.x 
76
Dopamine D1 receptors regulate protein synthesis-dependent long-term recognition memory via extracellular signal-regulated kinase 1/2 in the prefrontal cortex , LEARNING & MEMORY, 14( 3), 117- 125, Mar. 2007, https://doi.org/10.1101/lm.461407 
77
The rewards of nicotine: Regulation by tissue plasminogen activator-plasmin system through protease activated receptor-1 , JOURNAL OF NEUROSCIENCE, 26( 47), 12374- 12383, Nov. 2006, https://doi.org/10.1523/JNEUROSCI.3139-06.2006 
78
Involvement of tissue plasminogen activator-plasmin system in depolarization-evoked dopamine release in the nucleus accumbens of mice , MOLECULAR PHARMACOLOGY, 70( 5), 1720- 1725, Nov. 2006, https://doi.org/10.1124/mol.106.022467 
79
The magnetism responsive gene Ntan1 in mouse brain , NEUROCHEMISTRY INTERNATIONAL, 49( 4), 334- 341, Sep. 2006, https://doi.org/10.1016/j.neuint.2006.02.007 
80
Glutamate inhibits chondral mineralization through apoptotic cell death mediated by retrograde operation of the cystine/glutamate antiporter , JOURNAL OF BIOLOGICAL CHEMISTRY, 281( 34), 24553- 24565, Aug. 2006, https://doi.org/10.1074/jbc.M600939200 
81
Maturation-dependent reduced responsiveness of intracellular free Ca2+ ions to repeated stimulation by N-methyl-D-aspartate in cultured rat cortical neurons , NEUROCHEMISTRY INTERNATIONAL, 49( 3), 230- 237, Aug. 2006, https://doi.org/10.1016/j.neuint.2006.01.010 
82
Functional expression of A glutamine transporter responsive to down-regulation by lipopolysaccharide through reduced promoter activity in cultured rat neocortical astrocytes. , Journal of neuroscience research, 83( 8), 1447- 60, Jun. 2006, https://doi.org/10.1002/jnr.20855 
83
Chronic vitamin D-3 treatment protects against neurotoxicity by glutamate in association with upregulation of vitamin D receptor mRNA expression in cultured rat cortical neurons , JOURNAL OF NEUROSCIENCE RESEARCH, 83( 7), 1179- 1189, May. 2006, https://doi.org/10.1002/jnr.20824 
84
Nuclear condensation of cyclic adenosine monophosphate responsive element-binding protein in discrete murine brain structures , JOURNAL OF NEUROSCIENCE RESEARCH, 80( 5), 667- 676, Jun. 2005, https://doi.org/10.1002/jnr.20504 
85
A mechanism for modulation of N-methyl-D-aspartate receptor channels by free ferrous ions in cultured rat cortical neurons , Japanese Journal of Neuropsychopharmacology, 25( 2), 105- 113, Apr. 2005,  
86
Protection by exogenous pyruvate through a mechanism related to monocarboxylate transporters against cell death induced by hydrogen peroxide in cultured rat cortical neurons , JOURNAL OF NEUROCHEMISTRY, 93( 1), 84- 93, Apr. 2005, https://doi.org/10.1111/j.1471-4159.2005.02999.x 
87
Functional proteins involved in regulation of intracellular Ca2+ for drug development: Desensitization of N-methyl-D-aspartate receptor channels , JOURNAL OF PHARMACOLOGICAL SCIENCES, 97( 3), 348- 350, Mar. 2005, https://doi.org/10.1254/jphs.FMJ04007X4 
88
An increase in intracellular free calcium ions by nicotinic acetylcholine receptors in a single cultured rat cortical astrocyte , JOURNAL OF NEUROSCIENCE RESEARCH, 79( 4), 535- 544, Feb. 2005, https://doi.org/10.1002/jnr.20398 
89
Relevant modulation by ferrous ions of N-methyl-D-aspartate receptors in ischemic brain injuries , CURRENT NEUROVASCULAR RESEARCH, 1( 5), 429- 440, Dec. 2004,  
90
Nuclear transcription factors in the hippocampus , PROGRESS IN NEUROBIOLOGY, 68( 2), 145- 165, Oct. 2002, https://doi.org/10.1016/S0301-0082(02)00078-3 
91
Blockade by ferrous iron of Ca2+ influx through N-methyl-D-aspartate receptor channels in immature cultured rat cortical neurons , JOURNAL OF NEUROCHEMISTRY, 83( 1), 1- 11, Oct. 2002, https://doi.org/10.1046/j.1471-4159.2002.01042.x 
92
Transcription factors and drugs in the brain , JAPANESE JOURNAL OF PHARMACOLOGY, 89( 4), 337- 348, Aug. 2002, https://doi.org/10.1254/jjp.89.337 
93
Activator protein-1 complex expressed by magnetism in cultured rat hippocampal neurons , BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 292( 1), 200- 207, Mar. 2002, https://doi.org/10.1006/bbrc.2002.6618 
94
Nuclear degradation of particular fos family members expressed following injections of NMDA and kainate in murine hippocampus , NEUROCHEMICAL RESEARCH, 27( 1-2), 131- 138, Feb. 2002, https://doi.org/10.1023/A:1014866909035 
95
Dual mechanisms of Ca2+ increases elicited by N-methyl-D-aspartate mature cultured cortical in immature and neurons , JOURNAL OF NEUROSCIENCE RESEARCH, 67( 2), 275- 283, Jan. 2002, https://doi.org/10.1002/jnr.10096 
96
Differential in vitro degradation of particular Fos family members expressed by kainic acid in nuclear and cytosolic fractions of murine hippocampus , J Neurosci Res, 64,  34- 42, Apr. 1, 2001, https://doi.org/10.1002/jnr.1051 

 

MISC
No.Title URL, Journal, Vol( No), Start Page- End Page, Publication date 
1
Food-derived antidepressant-like compound ergothioneine promotes neuronal differentiation via activating mTORC1 and neurotrophic factor signaling in neural stem cells. , INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 19,  122- 122, Jun. 2016 
2
Attenuation of PTZ-induced epileptic seizure by deficiency in the gene encoding solute carrier OCTN1/SLC22A4 , INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 19,  268- 268, Jun. 2016 
3
Protective role of ergothioneine from tobacco smoke-induced oxidative stress in vitro and in vivo , FASEB JOURNAL, 30,   , Apr. 2016 
4
EXTRAPOLATION OF HEPATIC CLEARANCE FOR THE DRUGS METABOLIZED BY MONOAMINE OXIDASE FROM IN VITRO DATA , DRUG METABOLISM REVIEWS, 47,  207- 207, Nov. 2015 
5
FUNCTIONAL EXPRESSION OF OCTN1/SLC22A4 IN INTESTINAL MACROPHAGES DURING GASTROINTESTINAL INFLAMMATION , DRUG METABOLISM REVIEWS, 47,  284- 285, Nov. 2015 
6
EFFECT OF GLUCOCORTICOIDS ON EXPRESSION AND FUNCTION OF RENAL XENOBIOTIC TRANSPORTERS , DRUG METABOLISM REVIEWS, 47,  268- 268, Nov. 2015 
7
FUNCTIONAL CHARACTERIZATION OF ORGANIC CATION TRANSPORTER OCTN1 WITH SINGLE NUCLEOTIDE POLYMORPHISMS , DRUG METABOLISM REVIEWS, 47,  284- 284, Nov. 2015 
8
PHARMACODYNAMIC ROLES OF SOLUTE CARRIER OCTN1/SLC22A4 FOR GABAERGIC DRUGS IN MICE , DRUG METABOLISM REVIEWS, 47,  268- 269, Nov. 2015 
9
Analysis on mechanisms underlying the antidepressant effect of food-derived antioxidant ergothioneine , JOURNAL OF PHARMACOLOGICAL SCIENCES, 124,  83P- 83P, 2014 
10
Abnormal synapse formation in the hippocampus of solute carrier octn1 gene knockout mice , JOURNAL OF PHARMACOLOGICAL SCIENCES, 124,  99P- 99P, 2014 
11
Regulation of cellular proliferation by OCTN1/SLC22A4 expressed in murine neural stem cells , JOURNAL OF PHARMACOLOGICAL SCIENCES, 121,  98P- 98P, 2013 
12
ATP-induced delay of mitochondrial membrane potential disruption by NMDA in cultured rat hippocampal neurons , JOURNAL OF NEUROCHEMISTRY, 123,  83- 83, Oct. 2012 
13
OCTN1/SLC22A4 IS FUNCTIONALLY EXPRESSED IN HEPATIC NON-PARENCHYMAL CELLS , DRUG METABOLISM REVIEWS, 44,  140- 140, 2012 
14
GASTROINTESTINAL ABSORPTION OF METFORMIN REGULATED BY CARNITINE/ORGANIC CATION TRANSPORTER OCTN1 (SLC22A4) , DRUG METABOLISM REVIEWS, 44,  135- 135, 2012 
15
Suppression of differentiation by solute carrier OCTN1/SLC22A4 in murine neuroblastoma Neuro2a cells , JOURNAL OF PHARMACOLOGICAL SCIENCES, 118,  103P- 103P, 2012 
16
Functional analysis of carnitine/organic cation transporter OCTN1 (SLC22A4) expressed in mouse brain , JOURNAL OF PHARMACOLOGICAL SCIENCES, 115,  119P- 119P, 2011 
17
Gene knockout and metabolome analysis of carnitine/organic cation transporter OCTN1/SLC22A4 , DRUG METABOLISM REVIEWS, 42,  299- 299, Aug. 2010 
18
Pharmacokinetics and Hepatic Uptake of Eltrombopag, A Novel Platelet Increasing Agent , DRUG METABOLISM REVIEWS, 42,  307- 307, Aug. 2010 
19
Functional expression of carnitine/organic cation transporter OCTN1 (SLC22A4) in mouse , JOURNAL OF PHARMACOLOGICAL SCIENCES, 112,  253P- 253P, 2010 
20
Neuroprotection by notoginsenoside R1 against glutamate excitotoxicity , INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 13,  185- 185, 2010 
21
Promoted neuronal differentiation by static magnetism in neural progenitors , JOURNAL OF PHARMACOLOGICAL SCIENCES, 112,  240P- 240P, 2010 
22
Promotion by static magnetism of neuronal differentiation of neural progenitors , INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 13,  191- 191, 2010 
23
Protection by ATP against NMDA neurotoxicity in cultured rat hippocampal neurons , INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 13,  194- 194, 2010 
24
Acquired NMDA channels artificially expressed in HEK293 cells , INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 13,  185- 185, 2010 
25
Promotion of neuronal differentiation in neural progenitors exposed to static magnetism , NEUROSCIENCE RESEARCH, 68,  E130- E130, 2010 
26
Translocation of glutamine transporter expressed in C6 glioma cells , JOURNAL OF PHARMACOLOGICAL SCIENCES, 112,  140P- 140P, 2010 
27
Protection by notoginsenoside R1 against glutamate neurotoxicity , JOURNAL OF PHARMACOLOGICAL SCIENCES, 112,  240P- 240P, 2010 
28
Ifrd1 is predominantly expressed by adult mouse hippocampal progenitors , INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 13,  189- 189, 2010 
29
Responsiveness glia-derived neurotrophic factor to nicotine in cultured rat cortical astrocytes , INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 13,  188- 188, 2010 
30
Protection by ATP from NMDA neurotoxicity , JOURNAL OF PHARMACOLOGICAL SCIENCES, 112,  240P- 240P, 2010 
31
PREDOMINANT EXPRESSION OF IFRD1 BY NEURAL PROGENITOR CELLS IN ADULT MOUSE HIPPOCAMPUS , JOURNAL OF NEUROCHEMISTRY, 110,  27- 27, Sep. 2009 
32
MITOCHONDRIAL CALCIUM IN NMDA NEUROTOXICITY , JOURNAL OF NEUROCHEMISTRY, 110,  130- 130, Sep. 2009 
33
PROPERTIES OF ACQUIRED NMDA CHANNELS IN HEK293 CELLS , JOURNAL OF NEUROCHEMISTRY, 110,  128- 128, Sep. 2009 
34
FUNCTIONAL NMDA RECEPTOR EXPRESSION BY UNDIFFERENTIATED NEURAL PROGENITORS , JOURNAL OF NEUROCHEMISTRY, 110,  130- 131, Sep. 2009 
35
PROMOTION OF NEURONAL DIFFERENTIATION OF NEURAL PROGENITOR CELLS CULTURED UNDER STATIC MAGNETISM , JOURNAL OF NEUROCHEMISTRY, 110,  28- 28, Sep. 2009 
36
MITOCHONDRIAL MEMBRANE POTENTIAL DISRUPTION IN NMDA NEUROTOXICITY , JOURNAL OF NEUROCHEMISTRY, 110,  268- 268, Sep. 2009 
37
SUPPRESSION BY MYOSIN VI OF NEURAL PROGENITOR PROLIFERATION , JOURNAL OF NEUROCHEMISTRY, 110,  25- 25, Sep. 2009 
38
NEUROPROTECTIVE PROPERTIES OF ANTI-DIARRHEIC INGREDIENTS WITH A SINGLE PHENOL MOIETY , JOURNAL OF NEUROCHEMISTRY, 110,  129- 130, Sep. 2009 
39
TRANSACTIVATION OF GLIA-DERIVED NEUROTROPHIC FACTOR BY NICOTINE IN CULTURED RAT CORTICAL ASTROCYTES , JOURNAL OF NEUROCHEMISTRY, 110,  103- 103, Sep. 2009 
40
DOWN-REGULATION OF GLUTAMINE TRANSPORTER EXPRESSION BY LIPOPOLYSACCHARIDE IN CULTURED ASTROCYTES , JOURNAL OF NEUROCHEMISTRY, 110,  107- 108, Sep. 2009 
41
GLUTAMINE TRANSPORTER EXPRESSED BY GLIAL CELLS IN GLUTAMATE NEUROTOXICITY , JOURNAL OF NEUROCHEMISTRY, 110,  102- 102, Sep. 2009 
42
IRON-RELATED GENES EXPRESSED IN BRAIN , JOURNAL OF NEUROCHEMISTRY, 110,  62- 63, Sep. 2009 
43
NEUROPROTECTION BY ATP AGAINST NMDA TOXICITY , JOURNAL OF NEUROCHEMISTRY, 110,  52- 52, Sep. 2009 
44
PROMOTION OF ASTROGLIAL DIFFERENTIATION BY GROUP III METABOTROPIC GLUTAMATE RECEPTORS IN MURINE NEURAL PROGENITOR CELLS , JOURNAL OF NEUROCHEMISTRY, 110,  27- 28, Sep. 2009 
45
MODULATION OF PROLIFERATION AND DIFFERENTIATION BY GABAERGIC SIGNALING IN MURINE NEURAL PROGENITOR CELLS , JOURNAL OF NEUROCHEMISTRY, 110,  123- 123, Sep. 2009 
46
MYOSIN VI EXPRESSION IN RESPONSE TO TRAUMATIC STRESS IN MURINE HIPPOCAMPUS , JOURNAL OF NEUROCHEMISTRY, 110,  30- 30, Sep. 2009 
47
アストログリア細胞に発現するニコチン受容体 , 日本薬学会年会要旨集, 129th( 3), 184- 184, Mar. 5, 2009 
48
Mitochondrial calcium permeability in NMDA neurotoxicity , JOURNAL OF PHARMACOLOGICAL SCIENCES, 109,  254P- 254P, 2009 
49
A role of glutamine transporter expressed by glial cells in glutamate neurotoxicity , JOURNAL OF PHARMACOLOGICAL SCIENCES, 109,  160P- 160P, 2009 
50
ラット培養皮質アストロサイトのニコチン性シグナルによる神経細胞保護メカニズム(Mechanisms of neuroprotection by nicotinic signaling in cultured rat cortical astrocytes) , 神経化学, 47( 2-3), 237- 237, Aug. 2008 
51
Insensitivity to neurotoxicity by NMDA receptors due to delayed response of mitochondrial membrane potentials in cultured cortical neurons , INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 11,  214- 214, Jul. 2008 
52
Expression of a glutamine transporter by cultured astrocytes , INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 11,  215- 215, Jul. 2008 
53
Transient expression of functional NMDA receptors by undifferentiated neural progenitor cells , INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 11,  218- 218, Jul. 2008 
54
Exacerbation of oxidative stress vulnerability through upregulation of a glutamine transporter in cultured rat astrocytes , INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 11,  216- 216, Jul. 2008 
55
Modulation of proliferation and differentiation by GABAergic signals in murine neural progenitor cells , INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 11,  217- 217, Jul. 2008 
56
Suppression by group III metabotropic glutamate receptor of self-replication of undifferentiated neural progenitor cells , INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 11,  214- 214, Jul. 2008 
57
Expression of different glutamate receptors in brains of rats with middle cerebral artery occlusion , INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 11,  210- 210, Jul. 2008 
58
Neurite outgrowth suppression through overexpression of Ntan1 in murine neuroblastoma Neuro2a cells , INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 11,  215- 216, Jul. 2008 
59
Differential expression of a particular gene responsible for astroglial differentiation in neural progenitor cells of adult mouse hippocampus , INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 11,  215- 215, Jul. 2008 
60
海馬由来初代培養神経細胞におけるグルタミン酸誘発性神経細胞死に対するATPの保護効果 , 日本薬理学雑誌, 131( 3), 31P- 31p, Mar. 1, 2008 
61
Modulation a glutamine transporter expressed by cultured astrocytes of the vulnerability to oxidative stress , JOURNAL OF PHARMACOLOGICAL SCIENCES, 106,  137P- 137P, 2008 
62
Mitochondrial regulation of neuronal death by NMDA in rat primary neurons , , 27( 5), 288- 288, Nov. 25, 2007 
63
Phosphorylated CREB up-regulates a glutamine transporter in cultured rat neocortical astrocytes , , 27( 5), 319- 319, Nov. 25, 2007 
64
Role of dopamine D1 receptor/ERK1/2 signal in protein synthesis-dependent long-term recognition memory , JOURNAL OF PHARMACOLOGICAL SCIENCES, 103,  33P- 33P, 2007 
65
Neuroprotection by antidiarrheic ingredients in cultured hippocampal neurons , JOURNAL OF PHARMACOLOGICAL SCIENCES, 103,  87P- 87P, 2007 
66
Role of the tPA-plasmin-PAR1 signaling in nicotine rewards , JOURNAL OF PHARMACOLOGICAL SCIENCES, 103,  226P- 226P, 2007 
67
Functional analysis of Ntan1 in murine neuroblastoma Neuro2a cell line , JOURNAL OF PHARMACOLOGICAL SCIENCES, 103,  185P- 185P, 2007 
68
Desensitizaiton of NMDA receptor channels by repeated stimulation during neuronal maturation , Journal of the Pharmaceutical Society of Japan, 126,  118- 120, Sep. 8, 2006 
69
Comparison on glutamatergic signaling in cultured neurons isolated from different rat brain regions , JOURNAL OF NEUROCHEMISTRY, 98,  23- 23, Jul. 2006 
70
Desensitization of NMDA receptor channels by repeated stimulation in cultured rat cortical neurons , JOURNAL OF NEUROCHEMISTRY, 98,  107- 108, Jul. 2006 
71
Glutamine transporter expressed by cultured astrocytes , , 25( 6), 307- 307, Dec. 25, 2005 
72
Mechanisms underlying glutamate tolerance in cultured neurons , , 25( 6), 308- 308, Dec. 25, 2005 
73
培養アストロサイトにおけるニコチン刺激に伴う神経栄養因子の発現増強 , 日本生物学的精神医学会プログラム・講演抄録, 27th( 6), 216- 309, Dec. 25, 2005 
74
培養星状膠細胞における神経栄養因子発現のニコチンによる変化(Changes in expression of neurotrophic factors by nicotine in cultured astrocytes) , 神経化学, 44( 2-3), 181- 181, Aug. 2005 
75
Protection by exogenous pyruvate against cell death by hydrogen peroxide in cultured rat cortical neurons , JOURNAL OF NEUROCHEMISTRY, 94,  237- 238, Aug. 2005 
76
The role of functional nicotinic acetylcholine receptors in cultured rat cortical astrocytes , JOURNAL OF NEUROCHEMISTRY, 94,  90- 91, Aug. 2005 
77
Desensitization of NMDA receptor channels during maturation in cultured rat cortical neurons , JOURNAL OF NEUROCHEMISTRY, 94,  58- 58, Aug. 2005 
78
Glutamate toxicity in cultured neurons derived from different brain structures , JOURNAL OF NEUROCHEMISTRY, 94,  238- 238, Aug. 2005 
79
The glutamine transporter expressed by cultured rat cortical astrocytes , JOURNAL OF NEUROCHEMISTRY, 94,  99- 100, Aug. 2005 
80
培養アストロサイトに発現する機能的ニコチン受容体 , 生化学, 77( 7), 677- 677, Jul. 25, 2005 
81
異なる脳内部位由来初代培養神経細胞におけるグルタミン酸感受性の相違 , 日本薬理学雑誌, 125( 2), 21P- 21P, Feb. 1, 2005 
82
培養アストロサイトにおける機能的ニコチン受容体発現の可能性 , 日本薬理学雑誌, 125( 2), 22P- 22P, Feb. 1, 2005 
83
Effects of LPS on glutamine transporter expressed in cultured cortical astrocytes , JOURNAL OF PHARMACOLOGICAL SCIENCES, 97,  261P- 261P, 2005 
84
NMDA受容体チャネルの脱感作メカニズム , 日本神経精神薬理学雑誌, 24( 6), 344- 344, Dec. 25, 2004 
85
異なる脳内部位由来神経細胞におけるグルタミン酸シグナリング , 日本神経精神薬理学雑誌, 24( 6), 345- 345, Dec. 25, 2004 
86
培養アストロサイトにおける機能的ニコチン受容体の発現 , 日本神経精神薬理学雑誌, 24( 6), 420- 420, Dec. 25, 2004 
87
NMDA受容体チャネルの脱感作機構 , 日本薬理学雑誌, 124( 補冊1), 99P-100P- 100P, Nov. 1, 2004 
88
ニコチン適用に伴う培養アストロサイトの細胞内遊離Ca2+濃度変化(Changes in intracellular free Ca2+ by nicotine in cultured astrocytes) , 神経化学, 43( 2-3), 414- 414, Aug. 2004 
89
NMDA受容体のインターナライゼーション(Internalization of NMDA receptors) , 神経化学, 43( 2-3), 407- 407, Aug. 2004 
90
培養ラット脳神経細胞の成熟に伴うNMDA感受性の変化(Altered sensitivity to NMDA during maturation in cultured rat brain neurons) , 神経化学, 43( 2-3), 407- 407, Aug. 2004 
91
NMDA受容体チャネルの脱感作所要時間 , 日本薬学会年会要旨集, 124th( 4), 59- 59, Mar. 5, 2004 
92
培養アストロサイトに発現するnAChRsの機能解析 , 日本薬学会北陸支部総会及び例会プログラム・講演要旨集, 110th,  21- , 2004 
93
Desensitization of NMDA receptor channels , JOURNAL OF PHARMACOLOGICAL SCIENCES, 94,  58P- 58P, 2004 
94
Altered responsiveness to nicotine during cultured neuronal maturation , JOURNAL OF PHARMACOLOGICAL SCIENCES, 94,  287P- 287P, 2004 
95
脳内特定部位間のグルタメイトシグナルの相違性 , 日本薬学会北陸支部総会及び例会プログラム・講演要旨集, 110th,  22- , 2004 
96
Possible desensitization of NMDA receptors during cultured neuronal maturation , 日本神経精神薬理学雑誌, 23( 6), 231- 231, Dec. 25, 2003 
97
Protective effect of pyruvate on cell death induced by hydrogen peroxide in cultured rat cortical neurons , , 23( 6), 279- 279, Dec. 25, 2003 
98
Changes in nicotinic signaling mechanisms during in vitro maturation in cultured neurons , 日本神経精神薬理学雑誌, 23( 6), 275- 275, Dec. 25, 2003 
99
Altered sensitivity of NMDA receptor channels during cultured neuronal maturation , JOURNAL OF NEUROCHEMISTRY, 87,  79- 79, Dec. 2003 
100
NMDA受容体脱感作メカニズムの解析 , 生体膜と薬物の相互作用シンポジウム講演要旨集, 25th,  141- 144, Nov. 1, 2003 
101
初代培養神経細胞のインビトロ成熟に伴うNMDA受容体チャネル感受性変化(Altered sensitivity of NMDA receptor channels during in vitro maturation in cultured rat cortical neurons) , 神経化学, 42( 2-3), 238- 238, Aug. 2003 
102
Modulation by ferrous ions of intracellular free calcium ions in cultured rat cortical neurons exposed to NMDA , INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY, 17,  S156- S156, Aug. 2002 
103
Changes in mechanisms underlying elevation of intracellular free Ca2+ through NMDA receptors during in vitro maturation , JAPANESE JOURNAL OF PHARMACOLOGY, 88,  150P- 150P, 2002 
104
Characterization of ArfGAP1 and FinGER7/FinGER8 interaction by quantitative yeast two-hybrid analysis , J. Juzen Med. Soc., 122,  2218- 2227,   

 

Research Grants & Projects
No.Offer organization, System name, Title, Fund classification, Date 
1
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Elucidation of pharmacotherapeutic roles of xenobiotic uptake membrane transporters in epileptic seizures, ,  Apr. 2019 - Mar. 2022 
2
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Elucidation of intracellular mechanisms underlying neuronal maturation promoted by solute carrier OCTN1 and biomarker exploration in neuropsychiatric disorders, competitive_research_funding,  Apr. 2016 - Mar. 2019 
3
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Investigation of disease biomarkers using metabolome analysis targeted to transporters, ,  Apr. 2015 - Mar. 2019 
4
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Mechanism of postprandial hyperglycemia due to transporter gene knockout and identification of endogenous substrates, ,  Apr. 2015 - Mar. 2017 
5
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Study on prostaglandin transporter as a novel target for anti-inflammatory drugs, ,  Apr. 2015 - Mar. 2017 
6
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Transdermal drug delivery targeted to xenobiotics ABC transporters expressed in the skin, ,  Apr. 2013 - Mar. 2015 
7
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Elucidation of neural control mechanisms by solute carrier OCTN1 and the application to treatment of depression, competitive_research_funding,  Apr. 2013 - Mar. 2016 
8
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Investigation of pathophysiological roles of transporter for antioxidant with an aim to develop pharmacotherapeutics of inflammatory organ diseases, ,  Apr. 2012 - Mar. 2015 
9
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Development of triple-target antitumor drugs recognized by oligopeptide transporters, ,  2011 - 2012 
10
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Modulation of proliferation and differentiation capacitiesby solute carrier transporters in neural progenitor cells, ,  2010 - 2012 
11
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Research of transporter-adaptor network as target of drug effect and toxicity, ,  2008 - 2010 
12
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Regulatory mechanisms of cell survival by glutamine transporter in the brain, ,  2008 - 2009