Takasaki University of Health and Welfare

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NAKANISHI Takeo

Profile Research field Research achievement Educational achievement Management achievement Social contribution achievement

 

Books etc
No.Title URL, Autour Type, Publisher, Publication date, Range, ISBN 
1
Development of Formulations and Devices of Next-Generation Inhalations , Contributor, , Nov. 2018, , 9784781313535 
2
RSC Drug Discovery Series No. 54 Drug Transporters: Volume 1 Role and Importance in ADME and Drug Development , , The Royal Society of Chemistry, 2016, Chapter 6 Drug Transporters in the Lung: Expression and Potential Impact on Pulmonary DrugDisposition, 9781782620693 
3
DDS製剤の開発・評価と実用化手法 , , 技術情報協会, 2013, 消化管吸収トランスポ-タ-を利用したDDS開発,  
4
Transporters in drug discovery, development and use , , Aaps Press/Springer, 2013, Analysis of intestinal transporters,  
5
Springer Protocol-Membrane transporters in drug discovery and development. Methods and Protocols , , Humana Press/Springer Science/Business Media, Jun. 2010, Methods to Evaluate Transporter Activity in Cancer,  
6
Multidrug Resistance in Cancer , , Humana Press/Springer Science/Business Media, Feb. 2010, Impact of breast cancer resistance protein on cancer treatment outcomes.,  
7
薬物トランスポーター活用ライブラリー , , 羊土社, Nov. 2009, ,  
8
薬物トランスポーター活用ライブラリー , , 羊土社, Nov. 2009, SLC16A1, SLC16A2,  

 

Published Papers
No.Title URL, Journal, Vol( No), Start Page- End Page, Publication date, DOI 
1
Modulation of prostaglandin transport activity of SLCO2A1 by annexin A2 and S100A10 , American Journal of Physiology-Cell Physiology, ,   , Feb. 19, 2024, https://doi.org/10.1152/ajpcell.00701.2023 
2
An implication of the mitochondrial carrier SLC25A3 as an oxidative stress modulator in NAFLD , Experimental Cell Research, 431( 1), 113740- 113740, Oct. 2023, https://doi.org/10.1016/j.yexcr.2023.113740 
3
N-glycosylation modifies prostaglandin E2 uptake by reducing cell surface expression of SLCO2A1 , Prostaglandins & Other Lipid Mediators, 165,  106714- 106714, Apr. 2023, https://doi.org/10.1016/j.prostaglandins.2023.106714 
4
Biological Distribution after Oral Administration of Radioiodine-labeled Acetaminophen to Estimate Gastrointestinal Absorption Function via OATPs, OATs and/or MRPs. , Pharmaceutics,, 15( 2), 497- , Feb. 2023, https://doi.org/10.3390/pharmaceutics15020497 
5
A Single High-Dose Irradiation Changes Accumulation of Methotrexate and Gene Expression Levels of SLC and ABC Transporters in Cancer Cells , Frontiers in Pharmacology, 13,  1069321- 1069321, Jan. 2023, https://doi.org/10.3389/fphar.2022.1069321 
6
Assessment of hepatic prostaglandin E2 level in carbamazepine induced liver injury. , Endocrine regulations, 56( 1), 22- 30, Feb. 18, 2022, https://doi.org/10.2478/enr-2022-0003 
7
Phenolsulfonphthalein as a surrogate substrate to assess altered function of the prostaglandin transporter SLCO2A1 , Drug Metabolism and Pharmacokinetics, ,  100452- 100452, Feb. 2022, https://doi.org/10.1016/j.dmpk.2022.100452 
8
Biological Distribution of Orally Administered [123I]MIBG for Estimating Gastrointestinal Tract Absorption , Pharmaceutics, 14( 1), 61- 61, Dec. 28, 2021, https://doi.org/10.3390/pharmaceutics14010061 
9
MicroRNAs in Apple-Derived Nanoparticles Modulate Intestinal Expression of Organic Anion–Transporting Peptide 2B1/SLCO2B1 in Caco-2 Cells , Drug Metabolism and Disposition, 49( 9), 803- 809, Sep. 2021, https://doi.org/10.1124/dmd.121.000380 
10
Assessment of drug transporters involved in the urinary secretion of [99mTc]dimercaptosuccinic acid , Nuclear Medicine and Biology, 94-95,  92- 97, Mar. 2021, https://doi.org/10.1016/j.nucmedbio.2021.01.004 
11
Recent advances in studies of SLCO2A1 as a key regulator of the delivery of prostaglandins to their sites of action , Pharmacology & Therapeutics, ,  107803- 107803, Jan. 2021, https://doi.org/10.1016/j.pharmthera.2021.107803 
12
Post-transcriptional regulation of OATP2B1 transporter by a microRNA, miR-24. , Drug metabolism and pharmacokinetics, 35( 6), 515- 521, Dec. 2020, https://doi.org/10.1016/j.dmpk.2020.07.007 
13
[131I]MIBG exports via MRP transporters and inhibition of the MRP transporters improves accumulation of [131I]MIBG in neuroblastoma. , Nuclear medicine and biology, 90-91,  49- 54, Sep. 28, 2020, https://doi.org/10.1016/j.nucmedbio.2020.09.004 
14
Toxicological implication of prostaglandin transporter SLCO2A1 inhibition by cigarette smoke in exacerbation of lung inflammation , Toxicology and Applied Pharmacology, ,  115201- 115201, Aug. 2020, https://doi.org/10.1016/j.taap.2020.115201 
15
Contribution of Prostaglandin Transporter OATP2A1/SLCO2A1 to Placenta-to-Maternal Hormone Signaling and Labor Induction. , iScience, 23( 5), 101098- 101098, May. 22, 2020, https://doi.org/10.1016/j.isci.2020.101098 
16
Transport mechanism and affinity of [99mTc]Tc-mercaptoacetyltriglycine ([99mTc]MAG3) on the apical membrane of renal proximal tubule cells , Nuclear Medicine and Biology, 84-85,  33- 37, May. 2020, https://doi.org/10.1016/j.nucmedbio.2020.01.002 
17
The regulatory mechanism involved in the prostaglandin E2 disposition in carbon tetrachloride-induced liver injury. , Prostaglandins, leukotrienes, and essential fatty acids, 155,  102081- 102081, Apr. 2020, https://doi.org/10.1016/j.plefa.2020.102081 
18
Slco2a1 deficiency exacerbates experimental colitis via inflammasome activation in macrophages: a possible mechanism of chronic enteropathy associated with SLCO2A1 gene. , Scientific reports, 10( 1), 4883- 4883, Mar. 17, 2020, 10.1038/s41598-020-61775-9 
19
Slco2a1 deficiency exacerbates experimental colitis via inflammasome activation in macrophages: a possible mechanism of chronic enteropathy associated with SLCO2A1 gene. , Scientific reports, 10( 1), 4883- 4883, Mar. 17, 2020, https://doi.org/10.1038/s41598-020-61775-9 
20
Identification of the Uptake Transporter Responsible for Distribution of Acotiamide into Stomach Tissue. , Molecular pharmaceutics, ,   , Mar. 10, 2020, 10.1021/acs.molpharmaceut.9b00894 
21
Identification of the Uptake Transporter Responsible for Distribution of Acotiamide into Stomach Tissue. , Molecular pharmaceutics, ,   , Mar. 10, 2020, https://doi.org/10.1021/acs.molpharmaceut.9b00894 
22
The regulatory mechanism involved in the prostaglandin E2 disposition in carbon tetrachloride-induced liver injury. , Prostaglandins, leukotrienes, and essential fatty acids, 155,  102081- 102081, Feb. 21, 2020, 10.1016/j.plefa.2020.102081 
23
Author Correction: Imaging of hepatic drug transporters with [131I]6-β-iodomethyl-19-norcholesterol. , Scientific reports, 9( 1), 18478- , Dec. 2019, https://doi.org/10.1038/s41598-019-54992-4 
24
Imaging of hepatic drug transporters with [131I]6-β-iodomethyl-19-norcholesterol. , Scientific reports, 9( 1), 13413- 13413, Sep. 2019, https://doi.org/10.1038/s41598-019-50049-8 
25
Rat Kidney Slices for Evaluation of Apical Membrane Transporters in Proximal Tubular Cells. , J Pharm Sci, 108( 8), 2798- 2804, Aug. 2019, https://doi.org/10.1016/j.xphs.2019.03.031 
26
Uric acid analogue as a possible xenobiotic marker of uric acid transporter Urat1 in rats , Drug Metabolism and Pharmacokinetics, 34( 2), 155- 158, Apr. 2019, https://doi.org/10.1016/j.dmpk.2018.12.003 
27
Changes of drug pharmacokinetics mediated by downregulation of kidney organic cation transporters Mate1 and Oct2 in a rat model of hyperuricemia. , PLOS ONE, 14( 4), e0214862- , Apr. 2019, https://doi.org/10.1371/journal.pone.0214862 
28
Identification of MRP2 as a targetable factor limiting oxaliplatin accumulation and response in gastrointestinal cancer. , Sci. Rep, 9( 1), 2245- , Feb. 2019,  
29
Apple-Derived Nanoparticles Modulate Expression of Organic-Anion-Transporting Polypeptide (OATP) 2B1 in Caco-2 Cells. , Molecular pharmaceutics, 15( 12), 5772- 5780, Dec. 3, 2018, https://doi.org/10.1021/acs.molpharmaceut.8b00921 
30
Effect of tyrosine kinase inhibitors on renal handling of creatinine by MATE1 , Scientific Reports, 8( 1), 9237- , Dec. 1, 2018, https://doi.org/10.1038/s41598-018-27672-y 
31
Effect of endogenous multidrug resistance 1 and P-glycoprotein expression on anticancer drug resistance in colon cancer cell lines. , Biopharmaceutics & drug disposition, 40( 1), 32- 43, Dec. 2018, https://doi.org/10.1002/bdd.2167 
32
Different efflux transporter affinity and metabolism of 99mTc-2-methoxyisobutylisonitrile and 99mTc-tetrofosmin for multidrug resistance monitoring in cancer , Pharm Res, 36( 1), 18- 18, Nov. 2018, https://doi.org/10.1007/s11095-018-2548-5 
33
Experimental evidence for re-secretion of PGE2 across rat alveolar epithelium by OATP2A1/SLCO2A1-mediated transcellular transport , J Pharmacol Exp Ther, 368( 2), 317- 325, Nov. 2018, https://doi.org/10.1124/jpet.118.249789 
34
Membrane Transporters Contributing to PGE2 Distribution in Central Nervous System. , Biol Pharm Bull, 41( 9), 1337- 1347, Sep. 2018, https://doi.org/10.1248/bpb.b18-00169. 
35
Foreword , Biol Pharm Bull, 41( 9), 1322- 1323, Sep. 2018, https://doi.org/10.1248/bpb.b18-00169 
36
INVOLVEMENT OF PROSTAGLANDIN TRANSPORTER IN MURINE PLACENTAL PGE(2) DEGRADATION , PLACENTA, 69,  E86- , Sep. 2018,  
37
Prostaglandin Transporter OATP2A1/SLCO2A1 Is Essential for Body Temperature Regulation during Fever. , The Journal of neuroscience : the official journal of the Society for Neuroscience, 38( 24), 5584- 5595, Jun. 13, 2018, https://doi.org/10.1523/JNEUROSCI.3276-17.2018 
38
Contribution of equilibrative nucleoside transporters 1 and 2 to gemcitabine uptake in pancreatic cancer cells , Biopharmaceutics and Drug Disposition, 39( 5), 256- 264, May. 1, 2018, https://doi.org/10.1002/bdd.2131 
39
Regulatory Effect of Fruit-derived Nanoparticle on Intestinal Transporters , FASEB JOURNAL, 32( 1),  , Apr. 2018,  
40
Impact of breast cancer resistance protein expression on the in vitro efficacy of anticancer drugs in pancreatic cancer cell lines , Drug Metabolism and Disposition, 46( 3), 214- 222, Mar. 1, 2018, https://doi.org/10.1124/dmd.117.078402 
41
細胞内PGE2シグナルにおけるOATP2A1の役割 , 細胞, 50,  151- 153, Mar. 2018,  
42
Contribution of equilibrative nucleoside transporter(s) to intestinal basolateral and apical transports of anticancer trifluridine , Biopharmaceutics and Drug Disposition, 39( 1), 38- 46, Jan. 1, 2018, https://doi.org/10.1002/bdd.2110 
43
Roles of Organic Anion Transporting Polypeptide 2A1 (OATP2A1/SLCO2A1) in Regulating the Pathophysiological Actions of Prostaglandins , AAPS Journal, 20( 1), 13- , Jan. 1, 2018, https://doi.org/10.1208/s12248-017-0163-8 
44
A novel role for OATP2A1/SLCO2A1 in a murine model of colon cancer , SCIENTIFIC REPORTS, 7( 1), 16567- , Nov. 2017, https://doi.org/10.1038/s41598-017-16738-y 
45
Usefulness of kidney slices for functional analysis of apical reabsorptive transporters , SCIENTIFIC REPORTS, 7( 1), 12814- , Oct. 2017, https://doi.org/10.1038/s41598-017-12828-z 
46
プロスタグランジン輸送体が関わるPGE2分泌機構の提唱 , Bio Clinica, 32,  1117- 1121, Oct. 2017,  
47
Impact of FDA-Approved Drugs on the Prostaglandin Transporter OATP2A1/SLCO2A1 , JOURNAL OF PHARMACEUTICAL SCIENCES, 106( 9), 2483- 2490, Sep. 2017, https://doi.org/10.1016/j.xphs.2017.04.046 
48
Current Progress Toward a Better Understanding of Drug Disposition Within the Lungs: Summary Proceedings of the First Workshop on Drug Transporters in the Lungs , JOURNAL OF PHARMACEUTICAL SCIENCES, 106( 9), 2234- 2244, Sep. 2017, https://doi.org/10.1016/j.xphs.2017.04.011 
49
Association of miR-145 With Statin-Induced Skeletal Muscle Toxicity in Human Rhabdomyosarcoma RD Cells , JOURNAL OF PHARMACEUTICAL SCIENCES, 106( 9), 2873- 2880, Sep. 2017, https://doi.org/10.1016/j.xphs.2017.04.005 
50
Different Involvement of OAT in Renal Disposition of Oral Anticoagulants Rivaroxaban, Dabigatran, and Apixaban , JOURNAL OF PHARMACEUTICAL SCIENCES, 106( 9), 2524- 2534, Sep. 2017, https://doi.org/10.1016/j.xphs.2017.04.044 
51
Co-localization of microsomal prostaglandin E synthase-1 with cyclooxygenase-1 in layer II of murine placental syncytiotrophoblasts , PLACENTA, 53,  76- 82, May. 2017, https://doi.org/10.1016/j.placenta.2017.04.002 
52
Comparative Evaluation of Dehydroepiandrosterone Sulfate Potential to Predict Hepatic Organic Anion Transporting Polypeptide Transporter-Based Drug-Drug Interactions , DRUG METABOLISM AND DISPOSITION, 45( 2), 224- 227, Feb. 2017, https://doi.org/10.1124/dmd.116.072355 
53
PHARMACOKINETIC EVALUATION OF DEHYDROEPIANDROSTERONE SULFATE (DHEAS) AS AN ENDOGENOUS PROBE TO PREDICT DRUG-DRUG INTERACTION ON HEPATIC OATP IN RATS , DRUG METABOLISM AND PHARMACOKINETICS, 32( 1), S52- S53, Jan. 2017, 10.1016/j.dmpk.2016.10.217 
54
POTENTIAL OF PROSTAGLANDIN TRANSPORTER OATP2A1/SLCO2A1 AS A TARGET OF NOVEL ANTI-INFLAMMATORY DRUG , DRUG METABOLISM AND PHARMACOKINETICS, 32( 1), S102- S103, Jan. 2017, https://doi.org/10.1016/j.dmpk.2016.10.391 
55
UNAPPRECIATED ROLE OF PROSTAGLANDIN TRANSPORTERS IN PULMONARY FIBROSIS , DRUG METABOLISM AND PHARMACOKINETICS, 32( 1), S14- S14, Jan. 2017, https://doi.org/10.1016/j.dmpk.2016.10.069 
56
PHARMACOKINETIC EVALUATION OF DEHYDROEPIANDROSTERONE SULFATE (DHEAS) AS AN ENDOGENOUS PROBE TO PREDICT DRUG-DRUG INTERACTION ON HEPATIC OATP IN RATS , DRUG METABOLISM AND PHARMACOKINETICS, 32( 1), S52- S53, Jan. 2017, https://doi.org/10.1016/j.dmpk.2016.10.217 
57
EXPRESSION AND FUNCTION OF PROSTAGLANDIN TRANSPORTER IN THE MURINE PLACENTA , PLACENTA, 45,  129- 129, Sep. 2016, https://doi.org/10.1016/j.placenta.2016.06.235 
58
Methods to Discover Alternative Promoter Usage and Transcriptional Regulation of Murine Bcrp1 , JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 27( 111), 111- , May. 2016, https://doi.org/10.3791/53827 
59
Carrier-Mediated Prodrug Uptake to Improve the Oral Bioavailability of Polar Drugs: An Application to an Oseltamivir Analogue , JOURNAL OF PHARMACEUTICAL SCIENCES, 105( 2), 925- 934, Feb. 2016, https://doi.org/10.1016/j.xphs.2015.11.036 
60
Role of OATP2A1 in PGE(2) secretion from human colorectal cancer cells via exocytosis in response to oxidative stress , EXPERIMENTAL CELL RESEARCH, 341( 2), 123- 131, Feb. 2016, https://doi.org/10.1016/j.yexcr.2016.02.002 
61
Analysis of the Metabolic Pathway of Bosentan and of the Cytotoxicity of Bosentan Metabolites Based on a Quantitative Modeling of Metabolism and Transport in Sandwich-Cultured Human Hepatocytes , DRUG METABOLISM AND DISPOSITION, 44( 1), 16- 27, Jan. 2016, https://doi.org/10.1124/dmd.115.067074 
62
Prostaglandin transporter (OATP2A1/SLCO2A1) contributes to local disposition of eicosapentaenoic acid-derived PGE(3) , PROSTAGLANDINS & OTHER LIPID MEDIATORS, 122,  10- 17, Jan. 2016, https://doi.org/10.1016/j.prostaglandins.2015.12.003 
63
Local Drug-Drug Interaction of Donepezil with Cilostazol at Breast Cancer Resistance Protein (ABCG2) Increases Drug Accumulation in Heart , DRUG METABOLISM AND DISPOSITION, 44( 1), 68- 74, Jan. 2016, https://doi.org/10.1124/dmd.115.066654 
64
Organic Anion Transporting Polypeptide (OATP)2B1 Contributes to Gastrointestinal Toxicity of Anticancer Drug SN-38, Active Metabolite of Irinotecan Hydrochloride , DRUG METABOLISM AND DISPOSITION, 44( 1), 1- 7, Jan. 2016, https://doi.org/10.1124/dmd.115.066712 
65
Molecular localization and characterization of multiple binding sites of organic anion transporting polypeptide 2B1 (OATP2B1) as the mechanism for substrate and modulator dependent drug-drug interaction , MEDCHEMCOMM, 7( 9), 1775- 1782, 2016, https://doi.org/10.1039/c6md00235h 
66
Drug transporters in the lung: Expression and potential impact on pulmonary drug disposition , RSC Drug Discovery Series, 2016-( 54), 184- 227, 2016, https://doi.org/10.1039/9781782623793-00184 
67
OATP2A1/SLCO2A1-mediated prostaglandin E-2 loading into intracellular acidic compartments of macrophages contributes to exocytotic secretion , BIOCHEMICAL PHARMACOLOGY, 98( 4), 629- 638, Dec. 2015, https://doi.org/10.1016/j.bcp.2015.10.009 
68
EFFECTS OF FRUIT JUICES ON INTESTINAL DRUG TRANSPORTER, PEPT1 , DRUG METABOLISM REVIEWS, 47,  282- , Nov. 20, 2015,  
69
ARE UPTAKE TRANSPORTERS INVOLVED IN MEMBRANE TRANSPORT PROCESS OF ANTICOAGULANT DRUGS? , DRUG METABOLISM REVIEWS, 47,  295- , Nov. 20, 2015,  
70
BIPHASIC HEPATIC UPTAKE OF GEMCITABINE CHARACTERIZED BY CONTRIBUTION OF ENT1 AND ENT2 , Drug Metabolism Reviews, 47,  246- 246, Nov. 20, 2015,  
71
INCREASE OF RISK OF ACUTE RENAL FAILURE AND SERUM CREATININE LEVEL BY USE OF PIPERACILLIN/TAZOBACTAM , DRUG METABOLISM REVIEWS, 47,  181- , Nov. 20, 2015,  
72
LOCALIZATION OF TRANSPORTER AND ENZYMES REGULATING PROSTAGLANDIN E-2 LEVEL IN MOUSE PLACENTA , DRUG METABOLISM REVIEWS, 47,  286- 287, Nov. 20, 2015,  
73
UREMIC TOXINS ENHANCE BCRP-MEDIATED INTESTINAL URATE SECRETION IN CACO-2 CELLS , DRUG METABOLISM REVIEWS, 47,  289- 289, Nov. 20, 2015,  
74
POSSIBLE INVOLVEMENT OF OATP2B1 IN GASTROINTESTINAL TOXICITY INDUCED BY SN-38, THE ACTIVE METABOLITE OF ANTICANCER IRINOTECAN , DRUG METABOLISM REVIEWS, 47,  287- 288, Nov. 2015,  
75
PROSTAGLANDIN TRANSPORTER PGT RESPONSIBLE FOR REGULATING BIOLOGICAL FUNCTION OF EICOSAPENTAENOIC ACID-DERIVED PROSTAGLANDIN E-3 , DRUG METABOLISM REVIEWS, 47,  253- 253, Nov. 2015,  
76
HEPATOCYTE-BASED MATHEMATICAL MODELING REVEALS A NOVEL METABOLIC PATHWAY OF BOSENTAN IN HUMAN LIVER , DRUG METABOLISM REVIEWS, 47,  202- 203, Nov. 2015,  
77
RELEVANCE OF PROSTAGLANDIN TRANSPORTER (PGT) TO PGE(2) SECRETION FROM MACROPHAGES IN RESPONSE TO INFLAMMATORY STIMULATION , DRUG METABOLISM REVIEWS, 47,  288- 288, Nov. 2015,  
78
PROSTAGLANDIN TRANSPORTER (PGT)-MEDIATED PGE2 SECRETION FROM HUMAN COLORECTAL CANCER CELLS IN RESPONSE TO OXIDATIVE STRESS , DRUG METABOLISM REVIEWS, 47,  296- 297, Nov. 2015,  
79
[C-14]Fluciclovine (alias anti-[C-14]FACBC) uptake and ASCT2 expression in castration-resistant prostate cancer cells , NUCLEAR MEDICINE AND BIOLOGY, 42( 11), 887- 892, Nov. 2015, https://doi.org/10.1016/j.nucmedbio.2015.07.005 
80
MOUSE PLACENTAL DISTRIBUTION OF ENZYMES AND TRANSPORTER MODULATING PGE2 LEVEL , PLACENTA, 36( 10), A7- , Oct. 2015, https://doi.org/10.1016/j.placenta.2015.07.155 
81
Involvement of Concentrative Nucleoside Transporter 1 in Intestinal Absorption of Trifluridine Using Human Small Intestinal Epithelial Cells , JOURNAL OF PHARMACEUTICAL SCIENCES, 104( 9), 3146- 3153, Sep. 2015, https://doi.org/10.1002/jps.24455 
82
Kinetic Evaluation of Determinant Factors for Cellular Accumulation of Protoporphyrin IX Induced by External 5-Aminolevulinic Acid for Photodynamic Cancer Therapy , JOURNAL OF PHARMACEUTICAL SCIENCES, 104( 9), 3092- 3100, Sep. 2015, https://doi.org/10.1002/jps.24462 
83
Saturable Hepatic Extraction of Gemcitabine Involves Biphasic Uptake Mediated by Nucleoside Transporters Equilibrative Nucleoside Transporter 1 and 2 , JOURNAL OF PHARMACEUTICAL SCIENCES, 104( 9), 3162- 3169, Sep. 2015, https://doi.org/10.1002/jps.24498 
84
Corrigendum to "Kinetic analyses of trans-1-amino-3-[<sup>18</sup>F]fluorocyclobutanecarboxylic acid transport in Xenopus laevis oocytes expressing human ASCT2 and SNAT2" [Nucl. Med. Biol, 2013, 40, 670-675], doi: 10.1016/j.nucmedbio.2013.03.009 , Nuclear Medicine and Biology, 42( 5), 513- 514, May. 1, 2015, https://doi.org/10.1016/j.nucmedbio.2014.12.013 
85
Kinetic analyses of trans-1-amino-3-[F-18]fluorocyclobutanecarboxylic acid transport in Xenopus laevis oocytes expressing human ASCT2 and SNAT2 (vol 40, pg 670, 2013) , NUCLEAR MEDICINE AND BIOLOGY, 42( 5), 513- 514, May. 2015, https://doi.org/10.1016/j.nucmedbio.2014.12.013 
86
Prostaglandin Transporter (PGT/SLCO2A1) Protects the Lung from Bleomycin-Induced Fibrosis , PLOS ONE, 10( 4), e0123895- , Apr. 2015, https://doi.org/10.1371/journal.pone.0123895 
87
Organic anion transporting polypeptide 2B1 expression correlates with uptake of estrone-3-sulfate and cell proliferation in estrogen receptor-positive breast cancer cells , DRUG METABOLISM AND PHARMACOKINETICS, 30( 2), 133- 141, Apr. 2015, https://doi.org/10.1016/j.dmpk.2014.10.005 
88
Modeling approach for multiple transporters-mediated drug-drug interactions in sandwich-cultured human hepatocytes: Effect of cyclosporin A on hepatic disposition of mycophenolic acid phenyl-glucuronide , DRUG METABOLISM AND PHARMACOKINETICS, 30( 2), 142- 148, Apr. 2015, https://doi.org/10.1016/j.dmpk.2014.10.006 
89
Functional cyclic AMP response element in the breast cancer resistance protein (BCRP/ABCG2) promoter modulates epidermal growth factor receptor pathway- or androgen withdrawal-mediated BCRP/ABCG2 transcription in human cancer cells , BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, 1849( 3), 317- 327, Mar. 2015, https://doi.org/10.1016/j.bbagrm.2015.01.003 
90
In-vitro evidence of enhanced breast cancer resistance protein-mediated intestinal urate secretion by uremic toxins in Caco-2 cells , JOURNAL OF PHARMACY AND PHARMACOLOGY, 67( 2), 170- 177, Feb. 2015, https://doi.org/10.1111/jphp.12328 
91
Interaction of Drug or Food with Drug Transporters in Intestine and Liver , CURRENT DRUG METABOLISM, 16( 9), 753- 764, 2015,  
92
Identification of microRNAs associated with statin-induced skeletal muscle toxicity , Annual Meeting of the Japanese Society of Toxicology, 42,  P- 31, 2015, https://doi.org/10.14869/toxpt.42.1.0_P-31 
93
Accumulation of Trans-1-Amino-3-[F-18]Fluorocyclobutanecarboxylic Acid in Prostate Cancer due to Androgen-Induced Expression of Amino Acid Transporters , MOLECULAR IMAGING AND BIOLOGY, 16( 6), 756- 764, Dec. 2014, https://doi.org/10.1007/s11307-014-0756-x 
94
Putative roles of organic anion transporting polypeptides (OATPs) in cell survival and progression of human cancers , BIOPHARMACEUTICS & DRUG DISPOSITION, 35( 8), 463- 484, Nov. 2014, https://doi.org/10.1002/bdd.1915 
95
SGLT2 inhibitor lowers serum uric acid through alteration of uric acid transport activity in renal tubule by increased glycosuria , BIOPHARMACEUTICS & DRUG DISPOSITION, 35( 7), 391- 404, Oct. 2014, https://doi.org/10.1002/bdd.1909 
96
Substrate- and Dose-Dependent Drug Interactions with Grapefruit Juice Caused by Multiple Binding Sites on OATP2B1 , PHARMACEUTICAL RESEARCH, 31( 8), 2035- 2043, Aug. 2014, https://doi.org/10.1007/s11095-014-1305-7 
97
How Does Whisky Lower Serum Urate Level? , PHYTOTHERAPY RESEARCH, 28( 5), 788- 790, May. 2014, https://doi.org/10.1002/ptr.5063 
98
Transport mechanisms of hepatic uptake and bile excretion in clinical hepatobiliary scintigraphy with Tc-99m-N-pyridoxyl-5-methyltryptophan , NUCLEAR MEDICINE AND BIOLOGY, 41( 4), 338- 342, Apr. 2014, https://doi.org/10.1016/j.nucmedbio.2014.01.004 
99
More Relevant Prediction for In Vivo Drug Interaction of Candesartan Cilexetil on Hepatic Bile Acid Transporter BSEP Using Sandwich-cultured Hepatocytes , DRUG METABOLISM AND PHARMACOKINETICS, 29( 1), 94- 96, Feb. 2014, https://doi.org/10.2133/dmpk.DMPK-13-NT-049 
100
Mathematical Modeling of the in Vitro Hepatic Disposition of Mycophenolic Acid and Its Glucuronide in Sandwich-Cultured Human Hepatocytes , MOLECULAR PHARMACEUTICS, 11( 2), 568- 579, Feb. 2014, https://doi.org/10.1021/mp400513k 
101
IMPACT OF OATP2B1 EXPRESSION ON CELL PROLIFERATION IN ER-POSITIVE BREAST CANCER , DRUG METABOLISM REVIEWS, 45,  268- 268, Jan. 2014,  
102
MATHEMATICAL MODELING OF IN VITRO HEPATIC DISPOSITION OF MYCOPHENOLIC ACID AND ITS GLUCURONIDE IN SANDWICH-CULTURED HUMAN HEPATOCYTES , DRUG METABOLISM REVIEWS, 45,  163- 164, Jan. 2014,  
103
LONG-LASTING INHIBITION OF INTESTINAL ABSORPTIVE TRANSPORTER OATP2B1 BY FRUIT JUICE , DRUG METABOLISM REVIEWS, 45,  120- 120, Jan. 2014,  
104
Bcrp1 transcription in mouse testis is controlled by a promoter upstream of a novel first exon (E1U) regulated by steroidogenic factor-1 , BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, 1829( 12), 1288- 1299, Dec. 2013, https://doi.org/10.1016/j.bbagrm.2013.10.008 
105
In Vivo Evidence of Organic Cation Transporter-Mediated Tracheal Accumulation of the Anticholinergic Agent Ipratropium in Mice , JOURNAL OF PHARMACEUTICAL SCIENCES, 102( 9), 3373- 3381, Sep. 2013, https://doi.org/10.1002/jps.23603 
106
Kinetic analyses of trans-1-amino-3[F-18]fluorocyclobutanecarboxylic acid transport in Xenopus laevis oocytes expressing human ASCT2 and SNAT2 , NUCLEAR MEDICINE AND BIOLOGY, 40( 5), 670- 675, Jul. 2013, https://doi.org/10.1016/j.nucmedbio.2013.03.009 
107
A role of prostaglandin transporter in regulating PGE(2) release from human bronchial epithelial BEAS-2B cells in response to LPS , JOURNAL OF ENDOCRINOLOGY, 217( 3), 265- 274, Jun. 2013, https://doi.org/10.1530/JOE-12-0339 
108
Functional Cooperation of SMCTs and URAT1 for Renal Reabsorption Transport of Urate , DRUG METABOLISM AND PHARMACOKINETICS, 28( 2), 153- 158, Apr. 2013, https://doi.org/10.2133/dmpk.DMPK-12-RG-070 
109
Long-lasting inhibitory effect of apple and orange juices, but not grapefruit juice, on OATP2B1-mediated drug absorption , Drug Metabolism and Disposition, 41( 3), 615- 621, Mar. 2013, https://doi.org/10.1124/dmd.112.049635 
110
Functional cooperation of URAT1 (SLC22A12) and URATv1 (SLC2A9) in renal reabsorption of urate , NEPHROLOGY DIALYSIS TRANSPLANTATION, 28( 3), 603- 611, Mar. 2013, https://doi.org/10.1093/ndt/gfs574 
111
Major active components in grapefruit, orange, and apple juices responsible for OATP2B1-mediated drug interactions , JOURNAL OF PHARMACEUTICAL SCIENCES, 102( 1), 280- 288, Jan. 2013, https://doi.org/10.1002/jps.23357 
112
Major active components in grapefruit, orange, and apple juices responsible for OATP2B1-mediated drug interactions , Journal of Pharmaceutical Sciences, 102( 9), 3418- 3426, 2013, https://doi.org/10.1002/jps.23653 
113
OATP transporter-mediated drug absorption and interaction , Current Opinion in Pharmacology, 13( 6), 859- 863, 2013, https://doi.org/10.1016/j.coph.2013.09.001 
114
Cancer cells uptake porphyrins via heme carrier protein 1 , Journal of Porphyrins and Phthalocyanines, 17( 1-2), 36- 43, 2013, https://doi.org/10.1142/S1088424612501192 
115
Enhanced expression of organic anion transporting polypeptides (OATPs) in androgen receptor-positive prostate cancer cells: Possible role of OATP1A2 in adaptive cell growth under androgen-depleted conditions , BIOCHEMICAL PHARMACOLOGY, 84( 8), 1070- 1077, Oct. 2012, https://doi.org/10.1016/j.bcp.2012.07.026 
116
Active intestinal absorption of fluoroquinolone antibacterial agent ciprofloxacin by organic anion transporting polypeptide, Oatp1a5 , BIOPHARMACEUTICS & DRUG DISPOSITION, 33( 6), 332- 341, Sep. 2012, https://doi.org/10.1002/bdd.1809 
117
Application of quantitative time-lapse imaging (QTLI) for evaluation of Mrp2-based drug-drug interaction induced by liver metabolites , TOXICOLOGY AND APPLIED PHARMACOLOGY, 263( 2), 244- 250, Sep. 2012, https://doi.org/10.1016/j.taap.2012.06.016 
118
Species differences in the pharmacokinetics of KW-7158 [(2S)-(+)-3,3,3-Trifluoro-2-hydroxy-2-methyl-N-(5,5,10-trioxo-4,10-dihydrothieno[3,2-c][1]benzothiepin-9-yl)propanamide]: formation of hydrolyzed metabolite in human and animals , XENOBIOTICA, 42( 7), 649- 659, Jul. 2012, https://doi.org/10.3109/00498254.2011.652993 
119
Functional Pleiotropy of Organic Anion Transporting Polypeptide OATP2B1 Due to Multiple Binding Sites , DRUG METABOLISM AND PHARMACOKINETICS, 27( 3), 360- 364, Jun. 2012, https://doi.org/10.2133/dmpk.DMPK-11-SH-080 
120
Novel LC-MS/MS Method for Simultaneous Quantification of KW-7158, a New Drug Candidate for Urinary Incontinence and Bladder Hyperactivity, and its Metabolites in Rat Plasma: A Pharmacokinetic Study in Male and Female Rats , ARZNEIMITTELFORSCHUNG-DRUG RESEARCH, 62( 5), 213- 221, May. 2012, https://doi.org/10.1055/s-0032-1301883 
121
Extra-Renal Elimination of Uric Acid via Intestinal Efflux Transporter BCRP/ABCG2 , PLOS ONE, 7( 2), e30456- , Feb. 2012, https://doi.org/10.1371/journal.pone.0030456 
122
Genetic Polymorphisms of OATP Transporters and Their Impact on Intestinal Absorption and Hepatic Disposition of Drugs , DRUG METABOLISM AND PHARMACOKINETICS, 27( 1), 106- 121, Feb. 2012, https://doi.org/10.2133/dmpk.DMPK-11-RV-099 
123
Breast cancer resistance protein (BCRP/ABCG2): its role in multidrug resistance and regulation of its gene expression , CHINESE JOURNAL OF CANCER, 31( 2), 73- 99, Feb. 2012, https://doi.org/10.5732/cjc.011.10320 
124
Effect of back pressure on emulsification of lipid nanodispersions in a high-pressure homogenizer , INTERNATIONAL JOURNAL OF PHARMACEUTICS, 422( 1-2), 489- 494, Jan. 2012, https://doi.org/10.1016/j.ijpharm.2011.10.060 
125
Effect of back pressure on emulsification of lipid nanodispersions in a high-pressure homogenizer , INTERNATIONAL JOURNAL OF PHARMACEUTICS, 422( 1-2), 489- 494, Jan. 2012, https://doi.org/10.1016/j.ijpharm.2011.10.060 
126
Efflux transporter mRNA expression profiles in differentiating JEG-3 human choriocarcinoma cells as a placental transport model , Pharmazie, 67( 1),  , 2012, https://doi.org/10.1691/ph.2012.1593 
127
Functional Characterization of Apical Transporters Expressed in Rat Proximal Tubular Cells (PTCs) in Primary Culture , MOLECULAR PHARMACEUTICS, 8( 6), 2142- 2150, Nov. 2011, https://doi.org/10.1021/mp200096r 
128
Solute Carrier Transporters as Targets for Drug Delivery and Pharmacological Intervention for Chemotherapy , JOURNAL OF PHARMACEUTICAL SCIENCES, 100( 9), 3731- 3750, Sep. 2011, https://doi.org/10.1002/jps.22576 
129
Differential Effect of Grapefruit Juice on Intestinal Absorption of Statins Due to Inhibition of Organic Anion Transporting Polypeptide and/or P-glycoprotein , JOURNAL OF PHARMACEUTICAL SCIENCES, 100( 9), 3843- 3853, Sep. 2011, https://doi.org/10.1002/jps.22586 
130
Oxaliplatin Transport Mediated by Organic Cation/Carnitine Transporters OCTN1 and OCTN2 in Overexpressing Human Embryonic Kidney 293 Cells and Rat Dorsal Root Ganglion Neurons , JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 338( 2), 537- 547, Aug. 2011, https://doi.org/10.1124/jpet.111.181297 
131
Identification and characterization of the major alternative promoter regulating Bcrp1/Abcg2 expression in the mouse intestine , BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, 1809( 7), 295- 305, Jul. 2011, https://doi.org/10.1016/j.bbagrm.2011.06.004 
132
Identification and functional characterization of uric acid transporter Urat1 (Slc22a12) in rats. , Biochimica et biophysica acta, 1808( 6), 1441- 1447, Jun. 2011, https://doi.org/10.1016/j.bbamem.2010.11.002 
133
Quantitative Time-Lapse Imaging-Based Analysis of Drug-Drug Interaction Mediated by Hepatobiliary Transporter, Multidrug Resistance-Associated Protein 2, in Sandwich-Cultured Rat Hepatocytes , DRUG METABOLISM AND DISPOSITION, 39( 6), 984- 991, Jun. 2011, https://doi.org/10.1124/dmd.111.038059 
134
Identification and functional characterization of uric acid transporter Urat1 (Slc22a12) in rats , BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1808( 6), 1441- 1447, Jun. 2011, https://doi.org/10.1016/j.bbamem.2010.11.002 
135
Mechanism and interaction of absorptive drug transporters , DRUG METABOLISM REVIEWS, 43,  4- 5, May. 2011,  
136
Upregulation of organic anion-transporting polypeptide (OATP) 1A2 by depletion of androgens; a possible molecular mechanism of castration resistance in prostate cancer , DRUG METABOLISM REVIEWS, 43,  23- 23, May. 2011,  
137
A significant contribution of the organic cation/carnitine transporter, OCTN2, to tracheobronchial absorption of the anticholinergic bronchodilator, ipratropium , DRUG METABOLISM REVIEWS, 43,  82- 83, May. 2011,  
138
Putative Transport Mechanism and Intracellular Fate of Trans-1-Amino-3-F-18-Fluorocyclobutanecarboxylic Acid in Human Prostate Cancer , JOURNAL OF NUCLEAR MEDICINE, 52( 5), 822- 829, May. 2011, https://doi.org/10.2967/jnumed.110.086074 
139
Differential interaction of fruit juices with transporter-mediated absorption of drugs , DRUG METABOLISM REVIEWS, 43,  54- 54, May. 2011,  
140
Total Syntheses of (-)- and (+)-Goniomitine , ORGANIC LETTERS, 13( 7), 1796- 1799, Apr. 2011, https://doi.org/10.1021/ol200320z 
141
OCTN1-and OCTN2-mediated uptake of oxaliplatin in rat dorsal root ganglion neurons and HEK293 cells over-expressing OCTN1 or OCTN2 , CANCER RESEARCH, 71,   , Apr. 2011, https://doi.org/10.1158/1538-7445.AM2011-4391 
142
Drug Efflux by Breast Cancer Resistance Protein Is a Mechanism of Resistance to the Benzimidazole Insulin-Like Growth Factor Receptor/Insulin Receptor Inhibitor, BMS-536924 , MOLECULAR CANCER THERAPEUTICS, 10( 1), 117- 125, Jan. 2011, https://doi.org/10.1158/1535-7163.MCT-10-0438 
143
Organic Cation Transporter-Mediated Renal Secretion of Ipratropium and Tiotropium in Rats and Humans , DRUG METABOLISM AND DISPOSITION, 39( 1), 117- 122, Jan. 2011, https://doi.org/10.1124/dmd.110.035402 
144
Intestinal Absorption of HMG-CoA Reductase Inhibitor Pitavastatin Mediated by Organic Anion Transporting Polypeptide and P-Glycoprotein/Multidrug Resistance 1 , DRUG METABOLISM AND PHARMACOKINETICS, 26( 2), 171- 179, 2011, https://doi.org/10.2133/dmpk.DMPK-10-RG-073 
145
Carnitine Precursor gamma-Butyrobetaine is a Novel Substrate of the Na+- and Cl--dependent GABA Transporter Gat2 , DRUG METABOLISM AND PHARMACOKINETICS, 26( 6), 632- 636, 2011, https://doi.org/10.2133/dmpk.DMPK-11-NT-053 
146
A novel xenobiotic responsive element regulated by aryl hydrocarbon receptor is involved in the induction of BCRP/ABCG2 in LS174T cells , BIOCHEMICAL PHARMACOLOGY, 80( 11), 1754- 1761, Dec. 2010, https://doi.org/10.1016/j.bcp.2010.08.016 
147
Uptake transporter organic anion transporting polypeptide 1B3 contributes to the growth of estrogen-dependent breast cancer , JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 122( 4), 180- 185, Oct. 2010, https://doi.org/10.1016/j.jsbmb.2010.06.014 
148
Intestinal Absorption of HMG-CoA Reductase Inhibitor Pravastatin Mediated by Organic Anion Transporting Polypeptide , PHARMACEUTICAL RESEARCH, 27( 10), 2141- 2149, Oct. 2010, https://doi.org/10.1007/s11095-010-0216-5 
149
Impact of system L amino acid transporter 1 (LAT1) on proliferation of human ovarian cancer cells: A possible target for combination therapy with anti-proliferative aminopeptidase inhibitors , BIOCHEMICAL PHARMACOLOGY, 80( 6), 811- 818, Sep. 2010, https://doi.org/10.1016/j.bcp.2010.05.021 
150
Quantitative Visualization of Bile Canalicular Transporter Activity by Time-Lapse Imaging to Evaluate Drug-Drug Interaction in Sandwich-Cultured Hepatocytes , DRUG METABOLISM REVIEWS, 42,  290- 291, Aug. 2010,  
151
Involvement of Choline Transporter-Like Proteins, CTL1 and CTL2, in Glucocorticoid-Induced Acceleration of Phosphatidylcholine Synthesis via Increased Choline Uptake , BIOLOGICAL & PHARMACEUTICAL BULLETIN, 33( 4), 691- 696, Apr. 2010, https://doi.org/10.1248/bpb.33.691 
152
Side-population cells in luminal-type breast cancer have tumour-initiating cell properties, and are regulated by HER2 expression and signalling , BRITISH JOURNAL OF CANCER, 102( 5), 815- 826, Mar. 2010, https://doi.org/10.1038/sj.bjc.6605553 
153
Renal Secretion of Uric Acid by Organic Anion Transporter 2 (OAT2/SLC22A7) in Human , BIOLOGICAL & PHARMACEUTICAL BULLETIN, 33( 3), 498- 503, Mar. 2010, https://doi.org/10.1248/bpb.33.498 
154
Transport of Ipratropium, an Anti-Chronic Obstructive Pulmonary Disease Drug, Is Mediated by Organic Cation/Carnitine Transporters in Human Bronchial Epithelial Cells: Implications for Carrier-Mediated Pulmonary Absorption , MOLECULAR PHARMACEUTICS, 7( 1), 187- 195, Jan. 2010, https://doi.org/10.1021/mp900206j 
155
Species Difference in the Effect of Grapefruit Juice on Intestinal Absorption of Talinolol between Human and Rat , JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 332( 1), 181- 189, Jan. 2010, https://doi.org/10.1124/jpet.109.159756 
156
Impact of breast cancer resistance protein on cancer treatment outcomes. , Methods in molecular biology (Clifton, N.J.), 596,   , 2010,  
157
Methods to evaluate transporter activity in cancer. , Methods in molecular biology (Clifton, N.J.), 637,   , 2010, https://doi.org/10.1007/978-1-60761-700-6_5 
158
Hepatic uptake of gamma-butyrobetaine, a precursor of carnitine biosynthesis, in rats , AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 297( 4), G681- G686, Oct. 2009, https://doi.org/10.1152/ajpgi.00238.2009 
159
Role of OATP Transporters for Hepatic Uptake and Biliary Excretion of Beta-Lactam Antibiotics in Rats , DRUG METABOLISM REVIEWS, 41,  23- 23, Aug. 2009,  
160
OATP-mediated Intestinal Absorption of HMG-COA Reductase Inhibitors in Rats , DRUG METABOLISM REVIEWS, 41,  24- 25, Aug. 2009,  
161
Organic anion transporter OAT1 is involved in renal handling of citrulline , AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 297( 1), F71- F79, Jul. 2009, https://doi.org/10.1152/ajprenal.90662.2008 
162
Organic anion transporter OAT1 is involved in renal handling of citrulline , American Journal of Physiology - Renal Physiology, 297( 1), F71- F79, Jul. 2009, https://doi.org/10.1152/ajprenal.90662.2008 
163
Transport Characteristics of L-Citrulline in Renal Apical Membrane of Proximal Tubular Cells , BIOPHARMACEUTICS & DRUG DISPOSITION, 30( 3), 126- 137, Apr. 2009, https://doi.org/10.1002/bdd.653 
164
Preclinical Studies of Vorinostat (Suberoylanilide Hydroxamic Acid) Combined with Cytosine Arabinoside and Etoposide for Treatment of Acute Leukemias , CLINICAL CANCER RESEARCH, 15( 5), 1698- 1707, Mar. 2009, https://doi.org/10.1158/1078-0432.CCR-08-1587 
165
Drug efflux by breast cancer resistance protein (BCRP) is a mechanism of resistance to the insulin-like growth factor receptor/insulin receptor inhibitor, BMS-536924. , Cancer Research, 69( 2),  , 2009,  
166
The 44-kDa pim-1 kinase phosphorylates BCRP/ABCG2 and thereby promotes its multimerization and drug-resistant activity in human prostate cancer cells , JOURNAL OF BIOLOGICAL CHEMISTRY, 283( 6), 3349- 3356, Feb. 2008, https://doi.org/10.1074/jbc.M707773200 
167
Drug transporters as targets for cancer chemotherapy , Cancer Genomics and Proteomics, 4( 3), 241- 254, May. 2007, https://doi.org/10.1021/pr060207c 
168
Effect of forskolin on the expression of claudin-5 in human trophoblast BeWo cells , Pharmazie, 62( 4),  , 2007, https://doi.org/10.1691/ph.2007.4.6679 
169
The overexpression of ERBB receptor tyrosine kinases and ABC transporters is associated with an increased side population in hormone resistant breast cancer cells , Breast Cancer Research and Treatment, 106,   , 2007,  
170
Breast cancer cells resistant to anti-hormone treatments retain sensitivity to Aminoflavone (NSC 686288) , Molecular Cancer Therapeutics, 6( 12),  , 2007,  
171
Erratum: Novel 5′ untranslated region variants of BCRP mRNA are differentially expressed in drug-selected cancer cells and in normal human tissues: Implications for drug resistance, tissue-specific expression, and alternative promoter usage (Cancer Research (2007) 66, (5007-5011)) , Cancer Research, 67( 9),  , 2007, https://doi.org/10.1158/0008-5472.CAN-67-9-COR 
172
Alterations in the mitochondrial Proteome of adriamycin resistant MCF-7 breast cancer cells , JOURNAL OF PROTEOME RESEARCH, 5( 9), 2389- 2395, Sep. 2006, https://doi.org/10.1021/pr060207c 
173
Thapsigargin resistance in human prostate cancer cells , CANCER, 107( 3), 649- 659, Aug. 2006, https://doi.org/10.1002/cncr.22027 
174
Complex interaction of BCRP/ABCG2 and imatinib in BCR-ABL-expressing cells: BCRP-mediated resistance to imatinib is attenuated by imatinib-induced reduction of BCRP expression , BLOOD, 108( 2), 678- 684, Jul. 2006, https://doi.org/10.1182/blood-2005-10-4020 
175
Novel 5 ' untranslated region variants of BCRP mRNA are differentially expressed in drug-selected cancer cells and in normal human tissues: Implications for drug resistance, tissue-specific expression, and alternative promoter usage , CANCER RESEARCH, 66( 10), 5007- 5011, May. 2006, https://doi.org/10.1158/0008-5472.CAN-05-4572 
176
Characteristics of Transcription-regulatory Elements for Gene Expression from Plasmid Vectors in Human Trophoblast Cell Lines , Placenta, 27( 9-10),  , 2006, https://doi.org/10.1016/j.placenta.2006.02.007 
177
The ErB3-binding protein Ebp1 suppresses androgen receptor-mediated gene transcription and tumorigenesis of prostate cancer cells , PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 102( 28), 9890- 9895, Jul. 2005, https://doi.org/10.1073/pnas.0503829102 
178
Plasma pharmacokinetics and tissue distribution of the breast cancer resistance protein (BCRP/ABCG2) inhibitor fumitremorgin C in SCID mice bearing T8 tumors , CANCER CHEMOTHERAPY AND PHARMACOLOGY, 55( 2), 101- 109, Feb. 2005, https://doi.org/10.1007/s00280-004-0866-2 
179
Comparison of transgene expression mediated by several Fiber-modified adenovirus vectors in trophoblast cells , Placenta, 26( 10),  , 2005, https://doi.org/10.1016/j.placenta.2004.10.010 
180
Breast cancer resistance protein (BCRP/MXR/ABCG2) in adult acute lymphoblastic leukaemia: frequent expression and possible correlation with shorter disease-free survival , BRITISH JOURNAL OF HAEMATOLOGY, 127( 4), 392- 398, Nov. 2004, https://doi.org/10.1111/j.1365-2141.2004.05211.x 
181
Breast cancer resistance protein (BCRP/MXR/ABCG2) in acute myeloid leukemia: discordance between expression and function , LEUKEMIA, 18( 7), 1252- 1257, Jul. 2004, https://doi.org/10.1038/sj.leu.2403395 
182
The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme , JOURNAL OF BIOLOGICAL CHEMISTRY, 279( 23), 24218- 24225, Jun. 2004, https://doi.org/10.1074/jbc.M313599200 
183
Involvement of OCTN1 (SLC22A4) in pH-dependent transport of organic cations , MOLECULAR PHARMACEUTICS, 1( 1), 57- 66, Jan. 2004, https://doi.org/10.1021/mp0340082 
184
Functional characterization of human breast cancer resistance protein (BCRP, ABCG2) expressed in the Oocytes of Xenopus laevis , MOLECULAR PHARMACOLOGY, 64( 6), 1452- 1462, Dec. 2003, https://doi.org/10.1124/mol.64.6.1452 
185
Quantitative analysis of breast cancer resistance protein and cellular resistance to flavopiridol in acute leukemia patients , CLINICAL CANCER RESEARCH, 9( 9), 3320- 3328, Aug. 2003,  
186
Timed sequential therapy of acute leukemia with flavopiridol: In vitro model for a phase I clinical trial , CLINICAL CANCER RESEARCH, 9( 1), 307- 315, Jan. 2003,  
187
BCRP expression is regulated by hypoxia and provides a hypoxic survival advantage , Drug Metabolism Reviews, 35,  5- 5, 2003,  
188
Breast cancer resistance protein expression and function in adult acute lymphoblastic leukemia. , Blood, 102( 11),  , 2003,  
189
Transport of D-serine via the amino acid transporter ATB(0,+) expressed in the colon , BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 291( 2), 291- 295, Feb. 2002, https://doi.org/10.1006/bbrc.2002.6441 
190
Evaluation of Blood-Brain Barrier Transporters by Co-culture of Brain Capillary Endothelial Cells with Astrocytes , Drug Metabolism and Pharmacokinetics, 17( 1), 34- 41, 2002, https://doi.org/10.2133/dmpk.17.34 
191
Breast cancer resistance protein: Discordance between expression and function in acute myeloid leukemia. , Blood, 100( 11),  , 2002,  
192
Cloning and functional characterization of a new subtype of the amino acid transport system N , AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 281( 6), C1757- C1768, Dec. 2001,  
193
Na+- and Cl--coupled active transport of nitric oxide synthase inhibitors via amino acid transport system B-0,B-+ , JOURNAL OF CLINICAL INVESTIGATION, 107( 8), 1035- 1043, Apr. 2001, https://doi.org/10.1172/JCI12060 
194
Na+- and Cl- -coupled active transport of carnitine by the amino acid transporter ATB(0,+) from mouse colon expressed in HRPE cells and Xenopus oocytes , JOURNAL OF PHYSIOLOGY-LONDON, 532( 2), 297- 304, Apr. 2001, https://doi.org/10.1111/j.1469-7793.2001.0297f.x 
195
Structure, function, and tissue expression pattern of human SN2, a subtype of the amino acid transport system N , BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 281( 5), 1343- 1348, Mar. 2001, https://doi.org/10.1006/bbrc.2001.4504 
196
Na+- and Cl- -coupled transport of carnitine by the amino acid transporter ATB(0,+). , Faseb Journal, 15( 4),  , 2001,  
197
Structure and function of ATA3, a new subtype of amino acid transport system A, primarily expressed in the liver and skeletal muscle , BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 1509( 1-2), 7- 13, Dec. 2000, https://doi.org/10.1016/S0005-2736(00)00349-7 
198
Cancer cell-targeted drug delivery utilizing oligopeptide transport activity , INTERNATIONAL JOURNAL OF CANCER, 88( 2), 274- 280, Oct. 2000, https://doi.org/10.1002/1097-0215(20001015)88:2<274::AID-IJC20>3.0.CO;2-5 
199
Primary structure, genomic organization, and functional and electrogenic characteristics of human system N 1, a Na+- and H+-coupled glutamine transporter , JOURNAL OF BIOLOGICAL CHEMISTRY, 275( 31), 23707- 23717, Aug. 2000, https://doi.org/10.1074/jbc.M002282200 
200
Cloning of an amino acid transporter with functional characteristics and tissue expression pattern identical to that of system A , JOURNAL OF BIOLOGICAL CHEMISTRY, 275( 22), 16473- 16477, Jun. 2000, https://doi.org/10.1074/jbc.C000205200 
201
A new orally active antitumor 1R,2R-cyclohexanediamine-platinum(IV) complex: trans-(n-valerato)chloro(1R,2R-cyclohexanediamine)(oxalato)platinum(IV) , CANCER CHEMOTHERAPY AND PHARMACOLOGY, 43( 2), 97- 105, Feb. 1999,  
202
A new orally active antitumor 1R,2R-cyclohexanediamine-platinum(IV) complex: Trans-(n-valerato)chloro(1R,2R-cyclohexanediamine) (oxalato)platinum(IV) , Cancer Chemotherapy and Pharmacology, 43( 2), 97- 105, 1999, https://doi.org/10.1007/s002800050869 
203
Improvement of L-dopa absorption by dipeptidyl derivation, utilizing peptide transporter PepT1 , JOURNAL OF PHARMACEUTICAL SCIENCES, 87( 12), 1542- 1546, Dec. 1998, https://doi.org/10.1021/js980186o 
204
Direct evidence for peptide transporter (PepT1)-mediated uptake of a nonpeptide prodrug, valacyclovir , BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 250( 2), 246- 251, Sep. 1998, https://doi.org/10.1006/bbrc.1998.9298 
205
Significance of water solubility in the gastrointestinal absorption of trans-bis(n-valerato)(1R,2R-cyclohexanediamine)(oxalato)platinum(IV), an orally active antitumor platinum complex, and its analogs , ANTI-CANCER DRUGS, 9( 2), 167- 174, Feb. 1998,  
206
Utilization of oligopeptide transporter for tissue specific drug delivery , Proceedings of the Controlled Release Society, ( 25),  , 1998,  
207
Carrier-mediated transport of oligopeptides in the human fibrosarcoma cell line HT1080 , CANCER RESEARCH, 57( 18), 4118- 4122, Sep. 1997,  
208
The predominant contribution of oligopeptide transporter PepT1 to intestinal absorption of beta-lactam antibiotics in the rat small intestine , JOURNAL OF PHARMACY AND PHARMACOLOGY, 49( 8), 796- 801, Aug. 1997, https://doi.org/10.1111/j.2042-7158.1997.tb06115.x 
209
Tissue Selective Drug Derivery Utilizing Oligopeptide Transporter , Drug Metabolism and Pharmacokinetics, 12,  94- 95, 1997, https://doi.org/10.2133/dmpk.12.supplement_94 
210
Immunolocalization and pharmacological relevance of oligopeptide transporter PepT1 in intestinal absorption of beta-lactam antibiotics , FEBS LETTERS, 392( 1), 25- 29, Aug. 1996, https://doi.org/10.1016/0014-5793(96)00778-8 
211
An orally active antitumor cyclohexanediamine-Pt(IV) complex: trans,cis,cis-bis(n-valerato)(oxalato)(1R,2R-cyclohexanediamine)Pt(IV) , ANTI-CANCER DRUGS, 7( 3), 248- 256, May. 1996,  

 

MISC
No.Title URL, Journal, Vol( No), Start Page- End Page, Publication date 
1
尿酸排泄トランスポーター BCRPの特徴と尿酸輸送メカニズム , 尿酸と血糖, 3( 1), 22- 27, Jan. 2017 
2
薬物および内因性物質の肺動態調節に関わる輸送体 , ファインケミカル, ,   , Jan. 2015 
3
消化管トランスポーターによる医薬品の吸収促進 , Drug Delivery System, 5,  350- 360, 2012 
4
Oral drug delivery targeting intestinal transporter , Drug Delivery System, 27( 5), 350- 360, 2012 
5
Cancer cell-targeted drug delivery utilizing peptide transporter. , Int. J. Cancer, 88( 2), 274- 280, 2000 
6
Cancer cell-targeted drug delivery utilizing oligopeptide transport activity , International Journal of Cancer, 88( 2), 274- 280, 2000 

 

Conference Activities & Talks
No.Title, Conference, Publication date, Promoter, Venue 
1
Unappreciated roles of organic anion transporting polypeptides (OATPs) in human diseases, University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center Hormone-Responsive Cancer Program Special Seminar, Mar. 15, 2017, Hormone-Responsive Cancer Program, Baltimore, MD, USA 
2
肺線維症モデルを用いた炎症におけるプロスタグランジン輸送体OATP2A1の役割の検討, 第38回生体膜と薬物の相互作用シンポジウム, Nov. 16, 2016, 日本薬学会, 名古屋 
3
Attenuation of endotoxin-induced fever in prostaglandin transporter OATP2A1 global and macrophage-specific knockout mice., , Nov. 9, 2016, , Lawrence, KS, USA 
4
Involvement of intestinal transporter OATP2B1 in gastrointestinal toxicity induced by SN-38, an active metabolite of anticancer irinotecan, , Nov. 9, 2016, , Lawrence, KS, USA 
5
炎症性疾患におけるプロスタグランジントランスポーターの新規役割, 日本薬物動態学会31年会, Oct. 15, 2016, 日本薬物動態学会, 松本 
6
Alteration in PGE2 cellular disposition in murine macrophages by impaired function of prostaglandin transporter OATP2A1, , Oct. 14, 2016, ,  
7
Evaluation of Food-induced Effect on Intestinal Drug Disposition, , Oct. 14, 2016, ,  
8
Possible increase of serum creatinine levels by crizotinib due to inhibition of creatinine transporters, , Oct. 14, 2016, ,  
9
Possible increase of serum creatinine levels by crizotinib due to inhibition of creatinine transporters, , Oct. 14, 2016, ,  
10
Alteration in PGE2 disposition by subcellular localization of prostaglandin transporter,OATP2A1/SLCO2A1, The 21st International Symposium on Microsomes and Drug Oxidations, Oct. 2016, , Davis, CA, USA 
11
Alteration in PGE2 disposition by subcellular localization of prostaglandin transporter,OATP2A1/SLCO2A1, The 21st International Symposium on Microsomes and Drug Oxidations, Oct. 2016, , Davis, CA, USA 
12
Pathophysiological role of prostaglandin transporter OATP2A1/SLCO2A1 in pulmonary fibrosis, Workshop on Drug Transporters in the Lungs, Sep. 23, 2016, , Dlubin 
13
Role of Prostaglandin Transporter OATP2A1 in Inflammatory Phase in Bleomycin-induced Pulmonary Fibrosis, The 1st Workshop for Japan-Korea Young Scientists on Pharmaceutics, Jun. 24, 2016, Forum for Pharmaceutical Technology Inovation, Kyoto 
14
Prostaglandin Transporter OATP2A1 Contributes to PGE2 Secretion from Macrophages in Response to Inflammatory Stimulation, The 1st Workshop for Japan-Korea Young Scientists on Pharmaceutics, Jun. 24, 2016, Forum for Pharmaceutical Technology Inovation, Kyoto 
15
Inflammatory Fever Induced by LPS is Attenuated in Macrophage Specific OATP2A1 Knockout (Mφ-Slco2a1-/-) Mice, The 1st Workshop for Japan-Korea Young Scientists on Pharmaceutics, Jun. 24, 2016, Forum for Pharmaceutical Technology Inovation, Kyoto 
16
Unappreciated role of prostaglandin transporter OATP2A1 in inflammatory diseases, The 11th International Meeting of the International Society for the Study of Xenobiotics, Jun. 15, 2016, ISSX, Seoul 
17
肝OATP/Oatp上での薬物間相互作用を予測する内因性プローブとしてのDehydroepiandrosterone sulfate (DHEAS) の有用性評価, 日本薬学会第136年会, Mar. 27, 2016, 日本薬学会, 横浜 
18
プロスタグランジン輸送体 Slco2a1遺伝子欠損マウスにおけるリポ多糖誘発性体温上昇の抑制, 日本薬学会第136年会, Mar. 27, 2016, 日本薬学会, 横浜 
19
ブレオマイシン誘導性肺線維症モデル炎症期におけるプロスタグランジン輸送体OATP2A1の役割, 日本薬学会第136年会, Mar. 27, 2016, 日本薬学会, 横浜 
20
Impact of breast cancer resistance protein (BCRP/ABCG2) on chemotherapy; its function and gene regulation in cancer cells., 45th Annual Meeting of The Korean Society of Pharmaceutical Sciences and Technology (KSPST), Nov. 20, 2015, The Korean Society of Pharmaceutical Sciences and Technology (KSPST), Seoul, Korea 
21
OATP2B1によるSN-38の消化管動態調節を利用する消化器毒性回避法に関する研究, 第37回生体膜と薬物の相互作用シンポジウム, Nov. 19, 2015, 日本薬学会, 熊本 
22
OATP2A1のプロスタグランジンE2動態調節を介した炎症制御に関する研究, 第37回生体膜と薬物の相互作用シンポジウム, Nov. 19, 2015, 日本薬学会, 熊本 
23
コーヒー摂取が及ぼす消化管BCRP輸送活性上昇機構と尿酸・薬物動態への影響, 第37回生体膜と薬物の相互作用シンポジウム, Nov. 19, 2015, 日本薬学会, 熊本 
24
スタチン誘発性骨格筋毒性バイオマーカーとしてのmicroRNAの探索, 日本薬学会北陸支部第127回例会, Nov. 15, 2015, 日本薬学会, 富山 
25
FDA承認薬ライブラリを用いたプロスタグランジントランスポーターOATP2A1の阻害剤探索, 日本薬学会北陸支部第127回例会, Nov. 15, 2015, 日本薬学会, 富山 
26
A modeling of cellular disposition of external 5-aminolevlulinic acid (ALA)-induced protoporphyrin IX (PPIX) for photodynamic cancer therapy, 日本薬物動態学会30年会, Nov. 13, 2015, 日本薬物動態学会, 東京 
27
Involvement of OATP2B1-mediated accumulation of SN-38 in enterocytes for irinotecan-derived gastrointestinal toxicity, 日本薬物動態学会30年会, Nov. 12, 2015, 日本薬物動態学会, 東京 
28
miR-24 regulates expression and function of human OATP2B1, 日本薬物動態学会30年会, Nov. 12, 2015, 日本薬物動態学会, 東京 
29
Pyrogenic effect of endotoxin is attenuated in organic anion transporting polypeptide (OATP) 2A1 knockout (Slco2a1-/-) mice, 日本薬物動態学会30年会, Nov. 12, 2015, 日本薬物動態学会, 東京 
30
Hyperuricemina-induced endothelial dysifunction by non-linear down-regulation of BCRP, 日本薬物動態学会30年会, Nov. 12, 2015, 日本薬物動態学会, 東京 
31
Evaluation of microRNA associated with statin-induced skeletal muscle toxicity, 日本薬物動態学会30年会, Nov. 12, 2015, 日本薬物動態学会, 東京 
32
Role of Breast Cancer Resistance Protein (BCRP/ABCG2) in Multidrug Resistance and Its Gene Expression in Cancer Cells, 4th Guangzhou International Symposium on Oncology, Nov. 6, 2015, Guangzhou International Symposium on Oncology, Guangzhou, China 
33
スタチン誘発性骨格筋毒性発症に関わるmicroRNAの探索, 第42回日本毒性学会学術年会, Jun. 30, 2015, , 金沢 
34
プロスタグランジン輸送体OATP2A1は肺を線維症から保護する, 第10回トランスポーター研究会・中堅若手シンポジウム, Jun. 21, 2015, トランスポーター研究会, 慶応大学芝キャンパス、東京 
35
BCRP機能低下による尿酸の血管内皮細胞障害作用, 第10回トランスポーター研究会年会, Jun. 21, 2015, , 東京 
36
Pathophysiological significance of organic anion transporting polypeptide (OATP), , May. 6, 2015, ,  
37
有機アニオン輸送ポリペプチドOATPの病態生理学的意義, 富山大学大学院医学薬学研究部 特別講義, Apr. 23, 2015, 富山大学大学院医学薬学研究部, 富山大学杉谷キャンパス、富山 
38
大腸癌の増殖におけるプロスタグランジン輸送体PGTの役割, 日本薬学会第135年, Mar. 26, 2015, 日本薬学会, 神戸 
39
プロスタグランジン輸送体機能欠損による肺線維症, 日本薬学会第135年, Mar. 26, 2015, 日本薬学会, 神戸 
40
Pathophysiological significance of prostaglandin transporter (PGT/SLCO2A1), 7th DMPK Forum in Kanazawa by Industry-Academia Collaboration, Mar. 11, 2015, Faculty of Pharmaceutical Sciences, Kanazawa University, 金沢 
41
高尿酸血症によるBCRP輸送体活性低下が引き起こす血管障害促進メカニズム, 日本薬学会北陸支部第126回例会, Nov. 16, 2014, 日本薬学会, 金沢 
42
小腸上皮薬物輸送体OATP2B1に及ぼすフルーツジュースの持続的阻害作用, 日本薬学会北陸支部第126回例会, Nov. 16, 2014, 日本薬学会, 金沢 
43
Prostaglandin transporter PGT responsible for regulating biological function of eicosapentaenoic acid-derived prostaglandin E3, 19th North American ISSX and 29th JSSX Meeting, Oct. 19, 2014, ,  
44
Possible involvement of OATP2B1 in gastrointestinal toxicity induced by SN-38, the active metabolite of anticancer irinotecan, 19th North American ISSX and 29th JSSX Meeting, Oct. 19, 2014, ,  
45
Prostaglandin transporter (PGT)-medaited PGE2 secretion from human corolectal cancer cells in response to oxidative stress, 19th North American ISSX and 29th JSSX Meeting, Oct. 19, 2014, ,  
46
Are uptake transporters involved in membrane transport process of anticoagulant drugs?, 19th North American ISSX and 29th JSSX Meeting, Oct. 19, 2014, ,  
47
Uremic toxins enhance BCRP-mediated intestinal urate secretion in Caco-2 cells, 19th North American ISSX and 29th JSSX Meeting, Oct. 19, 2014, ,  
48
Localization of transporter and enzymes regulating prostaglandin E2 level in mouse placenta, 19th North American ISSX and 29th JSSX Meeting, Oct. 19, 2014, ,  
49
Hepatocyte-based mathematical modeling reveals a novel metabolic pathway of bosentan in human liver, 19th North American ISSX and 29th JSSX Meeting, Oct. 19, 2014, ,  
50
Increase of risk of acute renal failure and serum creatinine level by use of piperacillin/tazobactam, 19th North American ISSX and 29th JSSX Meeting, Oct. 19, 2014, ,  
51
Relevance of prostaglandin transporter (PGT) to PGE2 secretion from macrophages in response to inflammatory stimulation, 19th North American ISSX and 29th JSSX Meeting, Oct. 19, 2014, ,  
52
Effect of fruit juices on intestinal drug transporter, PEPT1, 19th North American ISSX and 29th JSSX Meeting, Oct. 19, 2014, ,  
53
Biphasic Hepatic Uptake of Gemcitabine Characterized by Contribution of ENT1 and ENT2, 19th North American ISSX and 29th JSSX Meeting, Oct. 19, 2014, ,  
54
プロスタグランジン輸送体PGTを標的する新しい薬物治療, 創剤フォーラム・第20回シンポジウム, Sep. 19, 2014, 創剤フォーラム, 金沢 
55
がん細胞に発現するトランスポーターと化学療法, 第22回クリニカルファーマシーシンポジウム・医療薬学フォーラム2014, Jun. 29, 2014, 日本薬学会, 東京 
56
輸送体による薬物および内因性物質の肺動態調節, 日本薬剤学会第29年会, May. 20, 2014, 日本薬剤学会, 大宮 
57
大腸癌由来LoVo細胞におけるPGTを介したPGE2調節, 日本薬学会第134年会, Mar. 29, 2014, 日本薬学会, 熊本 
58
アンドロゲン受容体陽性前立腺がん細胞の増殖におけるOATPの役割, 第7回 次世代を担う若手医療薬科学シンポジウム, Nov. 22, 2013, 日本薬学会, 仙台 
59
抗がん剤の多剤耐性予測における99mTcイメージング製剤の腫瘍細胞外排泄機構, 第53回日本核医学会学術総会, Nov. 8, 2013, 日本核医学会,  
60
More relevant prediction for in vivo drug interaction of candesartan cilexetil on hepatic bile acid transporter BSEP using sandwich-cultured hepatocytes, 日本薬物動態学会28年会, Oct. 9, 2013, 日本薬物動態学会, 東京 
61
A possible enhanced effect of coffee constituents on intestinal urate excretion via BCRP, 日本薬物動態学会28年会, Oct. 9, 2013, 日本薬物動態学会, 東京 
62
A role of prostaglandin transporter PGT (OATP1A2) to adjusting pulmonary PGE2 level, 日本薬物動態学会28年会, Oct. 9, 2013, 日本薬物動態学会, 東京 
63
Negative transcriptional regulation of organic anion transporting polypeptide (OATP) 1A2 in androgen receptor (AR)-positive prostate cancer cells, 日本薬物動態学会28年会, Oct. 9, 2013, 日本薬物動態学会, 東京 
64
Involvement of renal reabsorptive transporters in insulin-dependent increase of serum uric acid, 日本薬物動態学会28年会, Oct. 9, 2013, 日本薬物動態学会, 東京 
65
An animal model for role of prostaglandin transporter (PGT) in biological function of prostaglandins, 日本薬物動態学会28年会, Oct. 9, 2013, 日本薬物動態学会, 東京 
66
Mechanism of a long-lasting inhibitory effect of apple juice on intestinal uptake transporter OATP2B1, 日本薬物動態学会28年会, Oct. 9, 2013, 日本薬物動態学会, 東京 
67
Improvement of intestinal absorption of anti-viral guanidine oseltamivir carboxylate (GOC) mediated by transporters, 日本薬物動態学会28年会, Oct. 9, 2013, 日本薬物動態学会, 東京 
68
Structural identification of multiple binding sites on OATP2B1, 日本薬物動態学会28年会, Oct. 9, 2013, 日本薬物動態学会, 東京 
69
Possibility of ZOSIN-induced elevation of serum creatine level due to specific interaction on creatinine transporters without renal failure, 日本薬物動態学会28年会, Oct. 9, 2013, 日本薬物動態学会, 東京 
70
Mathematical modeling of in vitro hepatic disposition of mycophenolic acid and its glucuronide in sandwich-cultured human hepatocytes, 10th International ISSX Meeting, Sep. 29, 2013, ISSX, Toronto, Canada 
71
Impact of OATP2B1 expression on cell proliferation in ER-positive breast cancer, 10th International ISSX Meeting, Sep. 29, 2013, ISSX, Toronto, Canada 
72
Lasting inhibition of intestinal absorptive transporter OATP2B1 by fruits juice, 10th International ISSX Meeting, Sep. 29, 2013, ISSX, Toronto, Canada 
73
消化管トランスポーターを利用した吸収改善のストラテジー, 第29回日本DDS学会学術集会, Jul. 5, 2013, 日本DDS学会, 京都 
74
薬物動態・個体差要因可視化による個別化EBM(Evidence・Based・Medicine)の推進, 第29回日本DDS学会学術集会, Jul. 4, 2013, 日本DDS学会, 京都 
75
Transport mechanism of trans-1-amino-3-18F-fluorocyclobutanecarboxylic acid (18F-FACBC)PET radiotracer in human prostate cancer, The Society of Nuclear Medicine and Molecular Imaging's (SNMMI) 2013 Annual Meeting, Jun. 11, 2013, The Society of Nuclear Medicine and Molecular Imaging, Vancouver, Canada 
76
血管内皮細胞における尿酸輸送体を介した酸化ストレス調節, 第46回日本痛風・核酸代謝学会総会, Feb. 14, 2013, 日本痛風・核酸代謝学会, 東京 
77
Transporter as an emerging target for cancer therapy, 日本薬物動態学会第27年会, Nov. 21, 2012, 日本薬物動態学会, 東京 
78
Substrate-dependent drug-grapefruit juice interactions caused by multiple binding sites on OATP2B1, 日本薬物動態学会27年会, Nov. 20, 2012, 日本薬物動態学会, 東京 
79
OATP transporters is involved in intestinal absorption of urate, , Nov. 20, 2012, ,  
80
A role of prostaglandin transporter in regulating PGE2 release from human bronchial BEAS-2B cells under inflammatory conditions, 日本薬物動態学会27年会, Nov. 20, 2012, 日本薬物動態学会, 東京 
81
In vitro evidence for functional interplay of SMCT1 and URAT1 for renal reabsorption of urate, 日本薬物動態学会27年会, Nov. 20, 2012, 日本薬物動態学会, 東京 
82
Role of OCTN1 in ergothioneine cytoprotection against oxaliplatin toxicity in OCTN1 over-expressing HEK293 cells and cultured rodent dorsal root ganglion neurons, 日本薬物動態学会27年会, Nov. 20, 2012, 日本薬物動態学会, 東京 
83
Effect of drugs on renal urate reabsorption: evaluation by URAT1/URATv1 co-expressing cells, 日本薬物動態学会27年会, Nov. 20, 2012, 日本薬物動態学会, 東京 
84
Long-lasting effect of fruit juice on intestinal absorptive transporter OATP2B1, , Nov. 20, 2012, ,  
85
Application of quantitative time-lapse imaging (QTLI) for evaluation of MRP2/MRP2-based drug-drug interaction in rat and human hepatocytes, , Nov. 20, 2012, ,  
86
A role of prostaglandin transporter in regulation of intercellular PGE2 levels under inflammatory conditions, , Nov. 2012, ,  
87
In vitro evidence for functional interplay of SMCT1 and URAT1 for renal reabsorption of urate, , Sep. 2012, ,  
88
Enhanced carrier mediated transport: improving oral absorption of BCS Class Ⅲ antiviral drugs., 第28回日本DDS学会学術集会, Jul. 4, 2012, 日本DDS学会, 札幌 
89
肝代謝を考慮した蛍光イメージング(QTLI)法によるMRP2上での薬物間相互作用予測, 日本薬剤学会27年会, May. 24, 2012, 日本薬剤学会, 神戸 
90
ABC輸送体上での薬物相互作用に起因するDonepezilの心毒性リスク, 日本薬剤学会30年会, May. 24, 2012, 日本薬剤学会, 長崎 
91
前立腺癌細胞におけるトランスポーターを介したアンドロゲン供給調整機構の解明, 日本薬剤学会27年会, May. 24, 2012, 日本薬剤学会, 神戸 
92
Transporters as targets for drug delivery and therapy, , Apr. 17, 2012, ,  
93
URAT1/URATv1共発現細胞を用いたin vitro尿酸再吸収性変動評価, , Feb. 17, 2012, , 奈良 
94
BCRPを介した尿酸の腸管腔内分泌特性, 第45回日本痛風・核酸代謝学会総会, Feb. 17, 2012, 日本痛風・核酸代謝学会, 奈良 
95
トランスポーターを介した薬物—ジュース間相互作用機構, 日本薬学会北陸支部第123回例会, Nov. 29, 2011, 日本薬学会, 金沢 
96
ヒトがん細胞における5-アミノレブリン酸 (ALA) 誘導性プロトポルフィリンⅨ蓄積機構の解明, 日本薬学会北陸支部第123回例会, Nov. 29, 2011, 日本薬学会, 金沢 
97
In vitroイメージング (QTLI) 法を用いたMRP2機能変動評価 —肝代謝を考慮した薬物相互作用予測への応用—, 日本薬学会北陸支部第123回例会, Nov. 29, 2011, 日本薬学会, 金沢 
98
Upregulation of organic anion transporting polypeptides (OATPs) under the androgen-depletion conditions; A possible molecular mechanism for castration resistance in prostate cancer, , Nov. 16, 2011, ,  
99
In vitro evaluation model for renal reabsorption of uric acid: establishment of cells coexpressing URAT1 and URATv1, , Nov. 16, 2011, ,  
100
Evaluation of determinants factors for accumulation of 5-amminolevulinic acid (ALA)-induced protoporphyrin IX in cancer cells, , Nov. 16, 2011, ,  
101
Intestinal active secretion of uric acidcer, , Nov. 16, 2011, ,  
102
Functional pleiotropy of OATP2B1 due to multiple binding sites, , Nov. 16, 2011, ,  
103
Variability of juice-drug interaction in absorption process caused by multiple binding sites on OATP2B1, , Nov. 16, 2011, ,  
104
イプラトロピウムの気道上皮細胞膜透過における有機カチオントランスポーターの関与, 日本薬剤学会26年会, May. 29, 2011, 日本薬剤学会, 東京 
105
Side population cells with tumor-initiating cells properties are regulated by HER2 signaling in luminal-type breast cancer, 第11回春季シンポジウム金沢国際がん生物学シンポジウム, May. 26, 2011, 日本分子生物学会, 金沢 
106
Differential interaction of fruit juices on transporter-mediated absorption of drugs, , Apr. 2011, ,  
107
Upregulation of organic anion transporting polypeptide(OATP)1A2 by depletion of androgens; a possible molecular mechanism of castration resistance in prostate cancer., , Apr. 2011, ,  
108
A Significant contribution of organic cation/carnitine transporter, OCTN2, to tracheobronchial absorption of anti-cholinergic bronchodilator, ipratropium, , Apr. 2011, ,  
109
ラットにおける尿酸の腎外排泄機構, 第44回日本痛風・核酸代謝学会総会, Feb. 17, 2011, 日本痛風・核酸代謝学会, 東京 
110
イプラトロピウムの気道吸収における有機カチオン/カルニチントランスポーターの関与, 日本薬学会北陸支部第122回例会, Nov. 21, 2010, 日本薬学会, 金沢 
111
Difference Interaction of grapefruit juice with intestinal absorption of HMG-CoA reductase inhibitors pravastatin and pitavastatin, , Nov. 2010, ,  
112
Uric Acid Transporter-mediated uricosuric effect of RDEA594, a metabo I ite of antiviral agent RDEA806, , Nov. 2010, ,  
113
Mechanism of extra-renal excretion of uric acid in rats, , Oct. 7, 2010, ,  
114
Differential transporter-mediated interaction of fruit juice with pravastatin and pitavastatin in rats, , Oct. 7, 2010, ,  
115
Differential interaction of fruit juices on transporter-mediated absorption of drugs, , Oct. 7, 2010, ,  
116
System L-amino acid transporter 1 (LAT1) is a possible target for combination therapy with antiproliferative aminopeptidase inhibitors in human ovarian cancer cells., , Oct. 7, 2010, ,  
117
Tracheal absorption of an anticholinergic bronchodilator ipratropium via organic cation transporters., , Oct. 7, 2010, ,  
118
Differential expression of organic cation transporters in rat dorsal root ganglia, , Oct. 7, 2010, ,  
119
Quantitative visualization for bile canalicular transporter function using sandwich-cultured rat hepatocytes, , Oct. 7, 2010, ,  
120
Uptake transporter organic anion transporting polypeptide 1B3 contributes to the growth of estrogen-dependent breast cancer, , Sep. 2010, ,  
121
ヒト癌細胞株におけるOAT2を介した光線力学療法薬5-アミノレブリン酸の細胞膜輸送, 日本薬剤学会25年会, May. 14, 2010, 日本薬剤学会, 徳島 
122
がん標的分子としてのトランスポーターの可能性について, 大鵬薬品工業株式会社 特別講演, Mar. 5, 2010, 大鵬薬品工業株式会社, つくば市 
123
Mechanism for hepatic uptake of γ-butyrobetaine, a precursor of carnitine biosynthesis, 第31回生体膜と薬物の相互作用シンポジウム, Nov. 30, 2009, 日本薬学会, 大阪 
124
COPD治療薬の体内動態におけるトランスポーターの役割, 第32回生体膜と薬物の相互作用シンポジウム, Nov. 29, 2009, 日本薬学会, 富山 
125
Visualization of transport activity by live-cell time-lapse imaging for evaluation of intracellular transporter function, 日本薬物動態学会24年会, Nov. 27, 2009, 日本薬物動態学会, 京都 
126
Uric acid transporter-mediated uricosuric effect of RDEA594, a metabolite of antiviral agent RDEA806, 日本薬物動態学会24年会, Nov. 27, 2009, 日本薬物動態学会, 京都 
127
Interaction of diuretics with uric acid transporter urat1 as one of causes of antiuricosuric effect, 日本薬物動態学会24年会, Nov. 27, 2009, 日本薬物動態学会, 京都 
128
Regional difference of transporter-mediated absorption of drugs, 日本薬物動態学会24年会, Nov. 27, 2009, 日本薬物動態学会, 京都 
129
Pulmonary absorption of ipratropium via transporters in cultured human bronchial epithelial cells., 日本薬物動態学会24年会, Nov. 27, 2009, 日本薬物動態学会, 京都 
130
A molecular mechanism of hepatic uptake of gamma-butyrobetaine, a precursor of carnitine biosynthesis., , Nov. 27, 2009, ,  
131
HER2 expands tumor-initiating breast cancer cells in the side population - implications for targeted intervention, , Nov. 27, 2009, ,  
132
Relevance of organic cation transporter (OCT) 2 to renal secretion of ipratropium, , Nov. 27, 2009, ,  
133
DRUG TRANSPORTERS AS TARGETS FOR DRUG DELIVERY AND CANCER CHEMOTHERAPY., Asian Federation for Pharmaceutical Sciences 2009, Oct. 2009, ,  
134
Quantitative visualization of liver bile canalicular transporter activity by time-lapse imaging to evaluate drug-drug interaction in sandwich-cultured hepatocytes, , Sep. 2009, ,  
135
Role of OATP transporters for hepatic uptake and billiary excretion of beta-lactam antibiotics in rats, , May. 2009, , Bangkok, Thailand 
136
OATP-mediated intestinal absorption of HMG-CoA reductase inhibitors in rats, , May. 2009, , Bangkok, Thailand 
137
Alternative promoter activity of the human breast cancer resistance protein (BCRP/ABCG2) gene in drug-resistant cancer cells, , Apr. 2007, ,  
138
Overexpression of HER2/neu in breast cancer cell lines is associated with an increased side population, presence of ABC transporters, and clonogenicity, , Apr. 2007, ,  
139
Identification and characterization of the major alternative promoter controlling Bcrp1/Abcg2 expression in the mouse intestine, , Apr. 2007, ,  
140
Power-maximized experimental design and combination index surface analysis for evaluating interactions of drug combinations, with applications to suberoylanilide hydroxamic acid (SAHA) combined with etoposide (VP-16) in HL-60 human acute myeloid leukemia, , Apr. 2007, ,  
141
Principal Bcrp1 (Breast cancer resistance protein) mRNA isoform in the mouse intestine: Identification and promoter characterization predominant, , Sep. 2006, ,  
142
BCRP expression is functionally upregulated by epidermal growth factor receptor (EGFR, ErbB1) mediated signaling in human ovarian cancer cell lines, but not in human breast cancer cell lines, , Apr. 2006, ,  
143
Schedule Dependent Synergy of Suberoylanilide Hydroxamic Acid (SAHA or Vorinostat) in Combination with Cytarabine (ara-C) and Etoposide in HL-60 Human Acute Myeloid Leukemia Cells, , Apr. 2006, ,  
144
Complex interaction of BCRP/ABCG2 and STI-571 in BCR-ABL positive cells: BCRP-mediated resistance to STI-571 is attenuated by STI-571-induced reduction in BCRP expression, , Apr. 2005, ,  
145
Evaluation of the Mechanism of BCRP/ABCG2 Gene Overexpression of in Drug-Selected Multidrug Resistant Cells, , Mar. 2004, ,  
146
The stem cell marker (ABCG2) enhances hypoxic cell survival through interactions with heme, , Mar. 2004, ,  
147
Breast Cancer Resistance Protein Expression and Function in Adult Acute Lymphoblastic Leukemia, , Dec. 2003, ,  
148
Mechanisms of BCRP Overexpression in Drug-Selected Multidrug Resistant Cells, , Jul. 2003, ,  
149
Functional characterization of human BCRP expressed in Xenopus laevis oocytes, , Jul. 2003, ,  
150
The breast cancer resistance protein is upregulating by hypoxia and provides a survival advantage under hypoxic conditions, , Jul. 2003, ,  
151
Breast cancer resistance protein: Discordance between expression and function in acute myeloid leukemia, , Dec. 2002, ,  
152
Quantitative analysis of breast cancer protein (BCRP) and cellular resistance to flavopiridol in acute leukemia (AML) patients, American Association of Cancer Research, Apr. 2002, ,  
153
Primary structure, genomic organization, and functional and electrogenic characteristics of human system N (SN1), a sodium- and proton-coupled glutamine transporter., , Jun. 2000, , Boston 
154
Enforced expression and functional characterization of carnitine/organic anion transporter, OCTN2., 日本薬学会第120年会, Mar. 29, 2000, 日本薬学会, 岐阜 
155
Molecular and functional identification of organic anion transporter OATP family members important for hepatic elimination of β-lactam antibiotics in human. International Conference on Drug Interaction., , Oct. 1999, ,  
156
Cancer cell-targeted delivery of gestating by utilization of membrane transporter, , Sep. 29, 1999, ,  
157
Features in molecular recognition and transports of ACE inhibitors by peptide transporter, PepT1., , Mar. 29, 1999, ,  
158
トランスポーターの組織特異的な発現を利用した腫瘍組織ターゲティング戦略, 日本薬剤学会14年会, Mar. 26, 1999, 日本薬剤学会, 岡山 
159
Molecular recognition mechanism of peptide transporter, PepT1., , Nov. 1998, ,  
160
Characterization of oligopeptide transport activity in tumor cells and tumor specific drug delivery, , Oct. 1998, ,  
161
Utilization of oligopeptide transporter for tissue specific drug delivery, , Jun. 1998, , Las Vegas, NV, USA 
162
ペプチドトランスポーターPepT1に対する基質の阻害・輸送間相関, 日本薬剤学会13年会, Mar. 25, 1998, , 甲府 
163
ペプチド輸送系を利用した薬物の腫瘍組織ターゲティング, 日本薬剤学会13年会, Mar. 25, 1998, ,  
164
Studies for transporter-mediated targeting of tumor tissue using cultured cell lines., 日本薬学会第118年会, Mar. 1998, , 京都 
165
新規抗腫瘍性ヌクレオシドの細胞膜透過性, 日本薬物動態学会12年会, Nov. 4, 1997, ,  
166
オリゴペプチド輸送系の基質認識特性を利用した組織選択的薬物デリバリーは可能か., , Nov. 4, 1997, ,  
167
Research and development of orally active antitumor platinum complexes, - Anti-tumor activities and pharmacokinetics of oxaliplatin derivatives -, Symposium for biological reactions involved in metals, Jun. 1995, ,  
168
Research and development of orally active antitumor platinum complexes - Pharmacokinetics of trans, cis, ci-bis (velerato) (1R, 2R-cycolohexaanediamine)(oxalato)Pt(IV)-, , Mar. 1995, 日本薬学会,  
169
Unappreciated roles of organic anion transporting polypeptides (OATPs) in human diseases, University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center Hormone-Responsive Cancer Program Special Seminar, Mar. 15, 1027, University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA 
170
マクロファージからのPGE2開口分泌におけるプロスタグランジン輸送体の役割, 第56回日本脂質生化学会,  , 日本脂質生化学会,  
171
腫瘍細胞におけるペプチドトランスポート活性とペプチド性抗癌剤の薬効発現, 日本薬物動態学会13年会,  , 日本薬物動態学会, 浜松 
172
Improvement of Intestinal Absorption and Tissue Targeting of peptide-mimetic drugs by utilization of oligopeptide transporter, ,  , ,  
173
The overexpression of ERBB receptor tyrosine kinases and ABC transporters is associated with an increased side population in hormone resistant breast cancer cells., ,  , ,  
174
Breast Cancer Resistance Protein (BCRP, ABCG2) Transcriptional Upregulation in Drug-Selected Cells Bypasses the Physiologic Promoter, ,  , ,  
175
Evaluation of the Function of Breast Cancer Resistance Protein (BCRP/ABCG) Expressed in Xenopus Laevis Oocytes, ,  , ,  
176
Cloning of an amino acid transporter with functional characteristics and tissue expression pattern identical to that of system A., ,  , ,  
177
第8回ライフサイエンス研究交流セミナー, ,  , ,  
178
Selective delivery of peptide anticancer drugs via oligopeptide transporter expressed in cancer cells, ,  , ,  

 

Awards & Honors
No.Publication date, Association, Prize, Subtitle 
1
Dec. 2017, Effect of Fruit-derived Nanoparticle on Intestinal Transporters, 32nd JSSX Best Poster Award,  
2
Dec. 2017, 日本薬物動態学会, 第31回年会ベストポスター賞,  
3
Nov. 2017, , 2017 Top Reviewer in Journal of Pharmaceutical Sciences,  
4
Nov. 2016, , 2016 Top Reviewer in Journal of Pharmaceutical Sciences,  
5
Nov. 2015, Chinese Journal Cancer, 最優秀論文賞,  
6
Nov. 2012, , JSSX Young Investigator Award,  
7
Nov. 2009, 日本薬物動態学会, 第24回年会 ベストポスター賞 第1位,  
8
Oct. 2004, メリーランド大学グリーンバウムがんセンター, Distinguished Service Award,  
9
Mar. 1999, 日本薬剤学会(永井記念財団), Graduate Student Award,  

 

Research Grants & Projects
No.Offer organization, System name, Title, Fund classification, Date 
1
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, An implication of transporter-mediated regulation of brain PG concentration for mental diseases, ,  Apr. 2020 - Mar. 2023 
2
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Impact of transporters for uptake of estrogen precursors on progression of breast cancer cells, ,  Aug. 2013 - Mar. 2015 

 

Industrial Property Rights
No.Type, Title, ApplicationId, ApplicationDate, PatentId, Registration date, PatentDate 
1
, 細胞増殖性疾患の治療用または診断用薬剤, 特願2014-025935, Feb. 13, 2014, ,  ,   
2
, 分子イメージングにより代謝機能を測定するための検査薬, 特願2012-44231, Feb. 29, 2012, ,  ,