Takasaki University of Health and Welfare

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NAKAMURA Yoshinobu

Profile Research field Research achievement Educational achievement Management achievement Social contribution achievement

　

Published Papers
No.Ｔitle URL, Journal, Vol( No), Start Page- End Page, Publication date, DOI 
1
Modulation of prostaglandin transport activity of SLCO2A1 by annexin A2 and S100A10 , American Journal of Physiology-Cell Physiology, ,   , Feb. 19, 2024, https://doi.org/10.1152/ajpcell.00701.2023 
2
An implication of the mitochondrial carrier SLC25A3 as an oxidative stress modulator in NAFLD , Experimental Cell Research, 431( 1), 113740- 113740, Oct. 2023, https://doi.org/10.1016/j.yexcr.2023.113740 
3
N-glycosylation modifies prostaglandin E2 uptake by reducing cell surface expression of SLCO2A1 , Prostaglandins & Other Lipid Mediators, 165,  106714- 106714, Apr. 2023, https://doi.org/10.1016/j.prostaglandins.2023.106714 
4
Phenolsulfonphthalein as a surrogate substrate to assess altered function of the prostaglandin transporter SLCO2A1 , Drug Metabolism and Pharmacokinetics, 44,  100452- 100452, Jun. 2022, https://doi.org/10.1016/j.dmpk.2022.100452 
5
Alterations in cellular and organellar phospholipid compositions of HepG2 cells during cell growth , Scientific Reports, 11( 1),  , Jan. 2021, https://doi.org/10.1038/s41598-021-81733-3 
6
Recent advances in studies of SLCO2A1 as a key regulator of the delivery of prostaglandins to their sites of action , Pharmacology & Therapeutics, 223,  107803- 107803, Jan. 2021, https://doi.org/10.1016/j.pharmthera.2021.107803 
7
Toxicological implication of prostaglandin transporter SLCO2A1 inhibition by cigarette smoke in exacerbation of lung inflammation , Toxicology and Applied Pharmacology, ,  115201- 115201, Aug. 2020, https://doi.org/10.1016/j.taap.2020.115201 
8
Slco2a1 deficiency exacerbates experimental colitis via inflammasome activation in macrophages: a possible mechanism of chronic enteropathy associated with SLCO2A1 gene. , Scientific reports, ,   , Mar. 17, 2020, https://doi.org/10.1038/s41598-020-61775-9 
9
Quantification of Prostaglandin E2 Concentration in Interstitial Fluid from the Hypothalamic Region of Free-moving Mice , BIO-PROTOCOL, ,   , Aug. 5, 2019, https://doi.org/10.21769/bioprotoc.3324 
10
Membrane Transporters Contributing to PGE2 Distribution in Central Nervous System , Biological & pharmaceutical bulletin, ,   , Sep. 1, 2018, https://doi.org/10.1248/bpb.b18-00169 
11
Prostaglandin Transporter OATP2A1/SLCO2A1 Is Essential for Body Temperature Regulation during Fever , The Journal of neuroscience : the official journal of the Society for Neuroscience, ,   , May. 21, 2018, https://doi.org/10.1523/jneurosci.3276-17.2018 
12
Impact of FDA-Approved Drugs on the Prostaglandin Transporter OATP2A1/SLCO2A1. , Journal of pharmaceutical sciences, ,   , May. 4, 2017, https://doi.org/10.1016/j.xphs.2017.04.046 
13
Role of OATP2A1 in PGE(2) secretion from human colorectal cancer cells via exocytosis in response to oxidative stress. , Experimental cell research, ,   , Feb. 2, 2016, https://doi.org/10.1016/j.yexcr.2016.02.002 
14
OATP2A1/SLCO2A1-mediated prostaglandin E2 loading into intracellular acidic compartments of macrophages contributes to exocytotic secretion. , Biochemical pharmacology, ,   , Oct. 22, 2015, https://doi.org/10.1016/j.bcp.2015.10.009 

　

MISC
No.Ｔitle URL, Journal, Vol( No), Start Page- End Page, Publication date 
1
POTENTIAL OF PROSTAGLANDIN TRANSPORTER OATP2A1/SLCO2A1 AS A TARGET OF NOVEL ANTI-INFLAMMATORY DRUG , DRUG METABOLISM AND PHARMACOKINETICS, 32( 1), S102- S103, Jan. 2017 
2
RELEVANCE OF PROSTAGLANDIN TRANSPORTER (PGT) TO PGE(2) SECRETION FROM MACROPHAGES IN RESPONSE TO INFLAMMATORY STIMULATION , DRUG METABOLISM REVIEWS, 47,  288- , Nov. 20, 2015 

　

Conference Activities & Talks
No.Ｔitle, Conference, Publication date, Promoter, Venue 
1
Do hypotonicity and accessory proteins required for Maxi-Cl channel affect SLCO2A1-mediated prostaglandin E2 transport activity?, 2023 ICCP450/JSSX, Sep. 26, 2023, ,  
2
Role of N-glycosylation in the function and subcellular localization of prostaglandin transporter SLCO2A1, , Nov. 10, 2022, ,  
3
Phenol red as a novel substrate of prostaglandin transporter SLCO2A1, , Nov. 18, 2021, ,  
4
Brain region-specific regulation of prostaglandin D2 distribution by SLCO2A1, 35th JSSX, Dec. 1, 2020, ,  
5
Relevance of prostaglandin transporter (PGT) to PGE2 secretion from macrophages in response to inflammatory stimulation, , Oct. 21, 2014, ,  

　

Research Grants & Projects
No.Offer organization, System name, Title, Fund classification, Date 
1
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Analysis of thermoregulatory mechanisms by the CNS using model animals of female-dominant infectious hypothermia, ,  Sep. 2023 - Mar. 2027 
2
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity start-up, Elucidation of the mechanisms of subcellular localization of the prostaglandin transporter, ,  Sep. 2020 - Mar. 2022