應本　真 (オウモト　マコト,OUMOTO Makoto)

基本情報	研究分野	研究業績	教育業績	運営業績	社会貢献業績

論文
No.	論文タイトル URL, 誌名(出版物名), 巻( 号), 開始ページ- 終了ページ, 出版年月, DOI
1	A Transcription Factor Etv1/Er81 Is Involved in the Differentiation of Sweet, Umami, and Sodium Taste Cells , eneuro, 10( 4), ENEURO.0236- 22.2023, 2023年04月12日, https://doi.org/10.1523/eneuro.0236-22.2023
2	Maintenance and turnover of Sox2+ adult stem cells in the gustatory epithelium , PLOS ONE, 17( 9), e0267683- e0267683, 2022年09月02日, https://doi.org/10.1371/journal.pone.0267683
3	Expression of Eya1 in mouse taste buds. , Cell and tissue research, 383( 3), 979- 986, 2021年03月, https://doi.org/10.1007/s00441-020-03311-9
4	R-spondin substitutes for neuronal input for taste cell regeneration in adult mice , Proceedings of the National Academy of Sciences, 118( 2), , 2020年12月28日, https://doi.org/10.1073/pnas.2001833118
5	Sodium–Taste Cells Require Skn-1a for Generation and Share Molecular Features with Sweet, Umami, and Bitter Taste Cells , eneuro, 7( 6), ENEURO.0385- 20.2020, 2020年11月, https://doi.org/10.1523/eneuro.0385-20.2020
6	Tuft Cells Inhibit Pancreatic Tumorigenesis in Mice by Producing Prostaglandin D2. , Gastroenterology, 159( 5), 1866- 1881, 2020年11月, https://doi.org/10.1053/j.gastro.2020.07.037
7	SOX2 regulates homeostasis of taste bud cells and lingual epithelial cells in posterior tongue. , PloS one, 15( 10), e0240848- , 2020年, https://doi.org/10.1371/journal.pone.0240848
8	Bcl11b controls odorant receptor class choice in mice. , Communications biology, 2( 1), 296- , 2019年, https://doi.org/10.1038/s42003-019-0536-x
9	CALHM3 Is Essential for Rapid Ion Channel-Mediated Purinergic Neurotransmission of GPCR-Mediated Tastes. , Neuron, 98( 3), 547- 561, 2018年05月02日, https://doi.org/10.1016/j.neuron.2018.03.043
10	Activation of intestinal tuft cell-expressed sucnr1 triggers type 2 immunity in the mouse small intestine , Proceedings of the National Academy of Sciences of the United States of America, 115, 5552- 5557, 2018年05月, https://doi.org/10.1073/pnas.1720758115
11	Skn-1a/Pou2f3 functions as a master regulator to generate Trpm5-expressing chemosensory cells in mice , PLOS ONE, 12( 12), , 2017年12月, https://doi.org/10.1371/journal.pone.0189340
12	Genetic Lineage Tracing in Taste Tissues Using Sox2-CreERT2 Strain , CHEMICAL SENSES, 42( 7), 547- 552, 2017年09月, https://doi.org/10.1093/chemse/bjx032
13	Bcl11b/Ctip2 is required for development of lingual papillae in mice , DEVELOPMENTAL BIOLOGY, 416( 1), 98- 110, 2016年08月, https://doi.org/10.1016/j.ydbio.2016.06.001
14	CALHM1 deficiency impairs cerebral neuron activity and memory flexibility in mice , SCIENTIFIC REPORTS, 6, , 2016年04月, https://doi.org/10.1038/srep24250
15	Expression of serotonin receptor genes in cranial ganglia , NEUROSCIENCE LETTERS, 617, 46- 51, 2016年03月, https://doi.org/10.1016/j.neulet.2016.01.050
16	Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites , NATURE, 529( 7585), 226- U260, 2016年01月, https://doi.org/10.1038/nature16527
17	Normal Taste Acceptance and Preference of PANX1 Knockout Mice , CHEMICAL SENSES, 40( 7), 453- 459, 2015年09月, https://doi.org/10.1093/chemse/bjv025
18	Expression of the synaptic exocytosis-regulating molecule complexin 2 in taste buds and its participation in peripheral taste transduction , JOURNAL OF NEUROCHEMISTRY, 133( 6), 806- 814, 2015年06月, https://doi.org/10.1111/jnc.13073
19	Genetics of taste receptors , Current Pharmaceutical Design, 20, 2669- 2683, 2014年01月, https://doi.org/10.2174/13816128113199990566
20	Skn-1a/Pou2f3 is required for the generation of Trpm5-expressing microvillous cells in the mouse main olfactory epithelium , BMC NEUROSCIENCE, 15, , 2014年01月, https://doi.org/10.1186/1471-2202-15-13
21	Transgenic labeling of higher order neuronal circuits linked to phospholipase C-β2-expressing taste bud cells in medaka fish , Journal of Comparative Neurology, 521( 8), 1781- 1802, 2013年06月01日, https://doi.org/10.1002/cne.23256
22	CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes , NATURE, 495( 7440), 223- 226, 2013年03月, https://doi.org/10.1038/nature11906
23	Differential expression analysis throughout the weaning period in the mouse cerebral cortex , BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 431( 3), 437- 443, 2013年02月, https://doi.org/10.1016/j.bbrc.2012.12.150
24	Functional diversification of taste cells in vertebrates , Seminars in Cell and Developmental Biology, 24( 3), 210- 214, 2013年, https://doi.org/10.1016/j.semcdb.2012.10.004
25	Pou2f3/Skn-1a is necessary for the generation or differentiation of solitary chemosensory cells in the anterior nasal cavity , Bioscience, Biotechnology and Biochemistry, 77( 10), 2154- 2156, 2013年, https://doi.org/10.1271/bbb.130454
26	ACCUMULATION OF SNAP25 IN MOUSE GUSTATORY AND SOMATOSENSORY CORTICES IN RESPONSE TO FOOD AND CHEMICAL STIMULATION , NEUROSCIENCE, 218, 326- 334, 2012年08月, https://doi.org/10.1016/j.neuroscience.2012.05.045
27	Genetic tracing of the gustatory neural pathway originating from Pkd1l3-expressing type III taste cells in circumvallate and foliate papillae , JOURNAL OF NEUROCHEMISTRY, 119( 3), 497- 506, 2011年11月, https://doi.org/10.1111/j.1471-4159.2011.07443.x
28	Bcl11b/Ctip2 Controls the Differentiation of Vomeronasal Sensory Neurons in Mice , JOURNAL OF NEUROSCIENCE, 31( 28), 10159- 10173, 2011年07月, https://doi.org/10.1523/JNEUROSCI.1245-11.2011
29	Skn-1a (Pou2f3) specifies taste receptor cell lineage , NATURE NEUROSCIENCE, 14( 6), 685- 687, 2011年06月, https://doi.org/10.1038/nn.2820
30	Mutually exclusive expression of Gαia and Gα14 reveals diversification of taste receptor cells in zebrafish , Journal of Comparative Neurology, 519( 8), 1616- 1629, 2011年06月, https://doi.org/10.1002/cne.22589
31	Genetic tracing of the neural pathway for bitter taste in t2r5-WGA transgenic mice , BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 400( 4), 734- 738, 2010年10月, https://doi.org/10.1016/j.bbrc.2010.08.139
32	Spatial differences in molecular characteristics of the pontine parabrachial nucleus , BRAIN RESEARCH, 1296, 24- 34, 2009年10月, https://doi.org/10.1016/j.brainres.2009.07.098
33	Functional Organization of the Rodent Parabrachial Nucleus , INTERNATIONAL SYMPOSIUM ON OLFACTION AND TASTE, 1170, 378- 382, 2009年, https://doi.org/10.1111/j.1749-6632.2009.03883.x
34	Genetic Tracing of the Gustatory Neural Pathway Originating from T1R3-expressing Sweet/Umami Taste Receptor Cells , INTERNATIONAL SYMPOSIUM ON OLFACTION AND TASTE, 1170, 46- 50, 2009年, https://doi.org/10.1111/j.1749-6632.2009.03932.x
35	Genetic tracing of the gustatory and trigeminal neural pathways originating from T1R3-expressing taste receptor cells and solitary chemoreceptor cells , MOLECULAR AND CELLULAR NEUROSCIENCE, 38( 4), 505- 517, 2008年08月, https://doi.org/10.1016/j.mcn.2008.04.011
36	Transgenic labeling of taste receptor cells in model fish under the control of the 5′-upstream region of medaka phospholipase C-beta 2 gene , Gene Expression Patterns, 7( 1-2), 149- 157, 2007年01月, https://doi.org/10.1016/j.modgep.2006.06.004
37	Relation between acute and late irradiation impairment of four basic tastes and irradiated tongue volume in patients with head-and-neck cancer , INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 66( 5), 1422- 1429, 2006年12月, https://doi.org/10.1016/j.ijrobp.2006.08.037
38	Taste receptor cells express voltage-dependent potassium channels in a cell age-specific manner , CHEMICAL SENSES, 31( 8), 739- 746, 2006年10月, https://doi.org/10.1093/chemse/bjl016

受賞
No.	受賞年月, 授与機関, 賞名, (対象業績)タイトル
1	2022年07月, 公益財団法人三島海雲記念財団, 第11回（2022年度）三島海雲学術賞,
2	2019年09月, 日本味と匂学会, 研究奨励賞,
3	2018年02月, 公益財団法人ロッテ財団, 第5回（2018年度）ロッテ重光学術賞,

共同研究・競争的資金等の研究課題
No.	提供機関, 制度名, 課題名等, 資金種別, 研究期間
1	日本学術振興会, 科学研究費助成事業, 味細胞の産出・維持を制御する分子機構の解明, , 2024年04月 - 2028年03月
2	日本学術振興会, 科学研究費助成事業, 苦味を受容する味細胞の分化を制御する分子機構の解明, , 2020年04月 - 2023年03月
3	日本学術振興会, 科学研究費助成事業, 甘味・旨味・苦味・酸味受容細胞以外の味蕾細胞の機能解析, , 2009年 - 2010年